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Biomedical subjects

Zh V Solov'eva

Publications and source records attributed to Zh V Solov'eva.

At least 19 recordsLinked to original sources
PubMed1991

Metabolic and ultrastructural characteristics of biosynthetic processes in the cerebral cortex at 3 months following a prolonged hemorrhagic shock.

Biochemical indicators (the content of ATP, total RNA and DNA, acid and alkaline phosphatase activity) and ultrastructural changes in cells of the nerve tissue were studied in the cerebral cortex of anesthetized dogs 3 months after they had sustained a 4-h hemorrhagic shock (arterial pressure = 40 mmHg). A new variant of reconstruction of cell membranes and organelles that develops in neurons and gliocytes of the brain in the process of adaptation 3 months after resuscitation is identified. This reconstruction variant is described by (a) the presence of a monolayer of a substance with a medium electron density with the incorporated dense granules instead of the common three-layer organisation; (b) the ability displayed by the organellar structure to detect "errors" in its organisation; (c) changes in the character of intercellular relations. The development of this variant of cell structure in the postresuscitation period is likely to be based on the information disintegration of a cell as a system, resulting in distortion of biosynthesis of supracellular ensembles and biological membranes of nerve cells in particular.

Acid Phosphatase↗
PubMed1983

[Ultrastructural localization of lactate dehydrogenase activity in the brain cells of human embryos].

Results of studying the ultrastructural localization of lactate dehydrogenase (LDH) in the brain neuroectodermal cells of 7-11-week-old human embryos are presented. Young neurons and glioblasts display marked LDH activity. The reaction product is more frequently found in young neurons as compared to glioblasts. The number of active glial cells grows with embryonic development. The use of different incubation media makes it possible to differentiate the LDH-associated activity from the activity of succinate dehydrogenase, which oxidizes the endogenous tissue substrate. LDH is localized in mitochondria and hyaloplasm, while the activity in the plasma membranes and lamellar structures (detected by the ferrocyanide method) is largely related to succinate dehydrogenase functioning.

Brain↗
PubMed1980

[Lamellar formations in the brain cells of embryos of schizophrenic mothers].

Studies of the embryo brain obtained during abortions in schizophrenic mothers detected certain ultrastructural traits in the nervous tissue cellular elements. One of the most striking traits is the general increase in the surface of the intracellular membrane which appears due to the premature development of the usually present cell organellas (cytoplasmatic network, lamellar apparatus, mitochondria) and as a result of the increased proliferation of the membranes leading to formation of peculiar membrane structures--lamellasomes. The enhanced membrane proliferation gives grounds to assume that the increase in the general synthetic activity is due to the development in pathological conditions of adaptational reactions, which however are quite distinctive. The data obtained indicate a substantial distortion of cellular differentiation in the brain embryo of schizophrenic mothers.

Brain↗
PubMed1980

[Relationship between ultrastructural pathology of the embryonal brain and features of the course and treatment of schizophrenic mothers].

Evaluation of the ultrastructural changes in embryonic brain cells was made according to the intensity of two complexes--destructive and compensatory-proliferative. They were correlated with a number of clinical parameters (features of mother's disease, the condition at the moment of abortion, peculiarities of treatment, etc.). It was established that for schizophrenia, unlike other diseases, the compensatory-proliferative complex of changes is more typical. The most pronounced changes in brain ultrastructures were noted in embryos of the patients with acute psychotic states or in the decompensation stage in psychopathlike schizophrenia course. No correlation between the form of the disease course and intensity of mother's treatment was established.

Adolescent↗
PubMed1979

[Microglia-type cells in normal and pathologic human embryonic brains].

The brains of 7--12 week embryos, developing in normal and mentally ill females (normal--14, schizophrenia--12, other mental disorders--10) were studied by means of electron microscopy. It was established that the cells of the microglia type may be encountered in the brain of embryos beginning from 7 weeks. In the brain of embryos from normal females these cells had mainly a round or oval form (globose microglia). Axons were encountered relatively rarely. Some of the cells had protrusions of the pseudopodia-like type. In the brain of embryos from mentally ill females the cells of the microglia type have diverse, sometimes sticklike forms; they form multiple thin axons, actively fagocyte. The ultrastructure in such conditions was not destructed. These changes are considered to be the result of an increased activity of microglial cells under the influence of factors of the pathological process.

Brain↗
PubMed1976

[Certain structural details of developing in vitro human embryonal brain explants studied with the aid of fluorescence and scanning electron microscopy].

The bundles growing away from the explants were mainly formed by neuroblast processes. It has been shown that the degree of differentiation of neuroblasts depends on "the age" of embryonal brain. The bundles of neuroblasts are accompained by slightly differentiated cells, having their own processes descending to the surface of the lining. These processes attached to the surface of a bundle cover and have no connection with the inner structures of the bundle. The use of a scanning electron microscopy allows to detect some new details of the behaviour of nerve cells in vitro.

Brain↗
PubMed1976

[Changes in the ultra-fine structure of capillaries of the embryonic brain in the presence of schizophrenia in the mother].

The report is concerned with a study of fine structures of brain capillaries in 9 embryos received during medical abortions from schizophrenic mothers. The authors established some traits in the ultrastructure of endothelial cells in most of the studied cases--an increase of the surface of endothelial cells at the expense of a tortuosity of their plasmatic membranes and a formation of growths, vacuolization of the cytoplasma. There were also some changes in the structure of basal membranes. In 2 cases there were also peculiar pathological changes in the vascular endothelium: granules of an unknown nature in the endothelial cells and a focal lysis of the plasmatic membranes of endothelial cells.

Brain↗
PubMed1975

[Ultrastructural features of brain cells from the embryos of schizophrenic women].

With the use of the electron microscope the authors studied the embryonic brain tissue obtained during medical abortion of 6 female schizophrenic patients. Ultrastructural peculiarities of the cell elements in the embryonic brain in theses cases were estimated in comparison with those found in the embryonic brain of 14 mentally healthy women. There is a description of damages of membranes, mitochondrias and accumulation of granular material in the cytoplasma.

Brain↗