Biomedical subjects
Publications and source records attributed to Z Yu.
The components, toxicology, bioactivity and application of fibers of Radix Ophiopogonis (RO) were studied. The components of its fibers and roots are similar. In a clinical study with 100 aged patients, the aging syndromes were markedly improved. No side-effect was found.
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Post-quiescent potentiation (PQP), an enhanced contraction following a long pause that occurs as a result of increased Ca2+ release from intracellular stores, and post-stimulation potentiation (PSP), an enhanced contraction following a rapid series of contractions that is believed to be related to increased Ca2+ influx, were measured in streptozotocin-treated Wistar, spontaneously hypertensive (SHR), and Wistar-Kyoto (WKY) diabetic heart tissues. Decreased PQP values were found in Wistar and SHR diabetic papillary muscles (PM) in comparison with the same strain controls, which suggests a diminished degree of releasable Ca2+ from sarcoplasmic reticulum (SR) in these tissues. Decreased PSP was found in SHR diabetic PM, which may be related primarily to a depressed sarcolemmal (SL) Na(+)-Ca2+ exchange in this tissue. PSP was not decreased in diabetic Wistar or WKY cardiac preparations, indicating that Ca2+ entry via channels must be involved in the PSP mechanism. Ryanodine depressed PQP in Wistar and SHR PM, and SHR left atria in both control and diabetic tissues. It abolished PQP and SHR diabetic tissues but had no effect on WKY control and diabetic tissues. The data suggest that the ryanodine effect differs in the various strains of rat. These differences may be due to differences in the SR sensitivity to ryanodine among the strains. Diabetic SR with impaired Ca2+ uptake may contribute to these phenomena. Ryanodine depressed PSP of Wistar and SHR diabetic PM but had no effects on tissues from controls. The influence of ryanodine on diabetic SL Na(+)-Ca2+ exchange requires further investigation.
To understand the mechanisms of diabetic cardiomyopathy and the consequences of combined hypertension and diabetes, cardiac tissue responses to various inotropic agents were measured in experimental diabetes. Streptozotocin was injected into Wistar rats, spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats (WKYs). Six weeks after the injection diabetic rats showed a subsensitivity to beta adrenergic stimulation in ventricular tissue and a supersensitivity and hyper-responsiveness to Ca++ and alpha adrenergic stimulation (except in WKYs) in ventricular tissues and left atria. A supersensitivity to BAY K 8644 in SHR left atria and a hyper-responsiveness to verapamil in ventricular strips were also noted. These alterations may be due to a change in receptor number or to postreceptor alterations. Diabetic SHRs exhibited greater changes in several of the drug responses (responses to isoproterenol, phenylephrine and BAK 8644) were more hyperlipidemic and had a high mortality as compared with Wistar rats and WKY diabetics. These findings confirm that the combination of hypertension and diabetes results in greater cardiac pathology than is seen with either disease alone.
The anteroposterior radiographs and ultrasound measurements of vertebral columns ranging from 12 to 33 weeks' gestation were studied. Two kinds of regressive equations were developed: one for estimating the length of cervical, thoracic and lumbar regions of vertebral column in accordance to gestational ages, and the other for estimating the gestational ages on the basis of the length of cervical, thoracic and lumbar regions of vertebral column. The normal values with confidence interval in accordance to the length of lumbar vertebral column for estimating the gestational ages were obtained. Also presented were the adjusted values of intercept between the data of ultrasound measurement and X-ray measurement. The ossification centers of neural arch appeared first in the upper cervical vertebrae, then they extended towards the lower vertebrae. Ossification centers for the vertebral centra appeared first in the lower thoracic/upper lumbar region and then extended to the lower and upper centra, respectively. Combining the length of lumbar vertebral column with the appearance time of the ossification centers of cervical vertebral centra, sacral vertebral centra and sacral neural arch, the authors set a standard for assessing the developmental condition of 12-23 weeks' fetuses.
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This paper reports the classification, distributional traits, new distribution, specific species of medicinal fungi, as well as the status of anticancer medications and edible and medicinal fungi in Sichuan. Rational suggestions have been made with regard to the cultivation, development and utilization of those important species with proven curative effect.
The purpose of the present investigation was to determine the long-term prognosis of autotransplanted premolars with respect to tooth survival and pulpal healing. The material consisted of 195 patients aged 7 to 35 years, with a total of 370 autotransplanted premolars with observation period ranged from 1 to 13 years. Teeth transplanted with incomplete and complete root formation showed 95 per cent and 98 per cent long-term survival respectively: Pulp healing as evaluated by sensibility testing and radiographic signs of partial pulp canal obliteration was usually verified 6 months after transplantation. The frequency of pulpal healing (versus pulp necrosis), appeared to be closely related to stage of root development at time of transplantation. Teeth transplanted with incomplete and complete root formation showed 96 per cent and 15 per cent pulp healing respectively. Another and associated factor which could equally well predict pulpal healing was the diameter of the apical foramen of the graft. Finally, in teeth with completed root formation, the use of bursa with internal cooling and no extra-alveolar storage prior to transplantation seemed to increase the chance for pulpal healing. The present study indicates, that the size of the apical foramen and possibly the avoidance of bacterial contamination during the surgical procedure are explanatory factors for pulpal healing.
The purpose of the present investigation was to determine the long-term prognosis of autotransplanted premolars with respect to periodontal healing. The subjects consisted of 195 patients aged 7 to 35 years, with a total of 370 autotransplanted all operated and followed with a standard technique. The observation period ranged from 1 to 13 years. Periodontal healing as demonstrated radiographically was complete in most cases after 8 weeks. Root resorption occurring after transplantation was divided into surface-, inflammatory- and replacement resorption (ankylosis). Root resorption occurred in 52 of the transplanted teeth and was usually diagnosed within 6 months. Root resorption was found to be significantly related to increasing stage of root development and the stage of eruption at the time of transplantation. Subsequent orthodontic movement of teeth with completed root formation at the time of transplantation resulted in a slight increase in the frequency of both surface and inflammatory resorption. The present study indicates that trauma to the PDL of the transplant is the explanatory factor for the development of root resorption.
Tooth autotransplantation has recently become a method of treating certain orthodontic problems. Over a 13-year period 370 premolar transplants were monitored by electrometric pulp sensibility testing and radiographic examination for pulp and periodontal ligament healing as well as root growth. This article describes the surgical technique as well as the precision of sensibility testing and radiographic examination for evaluating transplant healing. The sensibility response was found markedly related to the stage of tooth development but not to the type of premolar. The precision of sensibility testing (i.e. deviation of two consecutive measurements at a few weeks' interval) was found to range from 15-36 per cent for the different stages. Film holders were used to standardize the intraoral radiographic exposures. The precision percentage for the measuring technique of tooth length and crown width based on a single radiograph read twice (reading error) ranged from 1.1 to 1.8 with only small variations among the different types of premolar. The precision percentage of the radiographic exposure technique evaluated from two consecutive radiographs (measuring plus exposure error) was found to range from 1.2 to 4.2, again with small variations among the different premolars. The accuracy of the radiographic technique (i.e. deviation of radiographically determined tooth dimensions from the true values) was found to range from 2.0 to 2.9 with only small variation between the various types of premolar. In conclusion the evaluation of electrometric sensibility testing should take into account the stage of root formation of premolars.
The purpose of the present study was to analyse the extent of root development subsequent to transplantation in a material of 370 transplanted premolars. Before transplantation, the grafts were classified according to stage of root development (i.e. quarters of root length and constriction of the apical foramen) and length of tooth development (measured in mm from the cusp tip to the apical foramen). At radiographic controls the extent of root formation was registered. These figures were compared to the final tooth length of 288 non-transplanted premolars from the present material as well as to tooth length determinations of 534 premolars extracted for orthodontic purposes. Furthermore, intra-individual and inter-individual differences in tooth length were examined in a skull material with 40 pairs of premolars. These method studies indicated that root growth was probably determined genetically with great right-left accuracy and variation related to location of premolar (maxilla or mandible) and sex. A statistical analysis of the transplant material revealed that stage as well as length of tooth development assessed prior to transplantation were significantly related to final tooth length after transplantation. In most cases of transplantation performed at early stages of root development, a reduction in the final root length was seen. When a qualitative analysis of root development was performed in teeth with incomplete root formation at the time of transplantation, and where a homologous non-transplanted premolar was present, it was found that 14 per cent showed total arrest of root formation, 65 per cent partial arrest whereas 21 per cent showed no arrest (i.e. normal root formation). Premolars in ectopic position in the mandible before transplantation showed a significantly reduced root growth compared to matched pairs with normal position of the tooth graft. The present study indicated that no, partial or total damage to the Hertwig's epithelial root sheath was probably the explanatory factor for variations in root growth.
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Bacillus sphaericus strain Ts-1 is highly insecticidal to larvae of the mosquito. It's insecticidal component is toxic proteins. The toxin was extracted from spore-crystal complexes by disruption in a Sonicator Cell Disruptor Model W-220F followed by treatment with 0.05 mol/L NaOH. Fraction recovered from chromatography of the spore-crystal complexes on column of Sephadex G-200 were assayed against mosquito larvae and the toxic fractions from gel chromatography were subjected to SDS-PAGE. The toxic proteins in B. sphaericus Ts-1 spore-crystal complex migrated in position corresponding to 42kD and 43kD. Bioassay of the two purified proteins prepared by PAGE indicated that they were all toxic to mosquito larvae. Toxic protein was further purified by DEAE-cellulose chromatography. The toxic protein with a molecular weight of 42kD was obtained.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Some 2-substituted-(2'-aminophenyl)-4-thioxohydantoic acids (o-amino PTC-amino acids) have antinociceptive activity when administered (icv) alone (IC50 = 0.04-0.87 microM/animal) and show a striking prolongation of the antinociceptive action of (D-Ala-2 D-Leu5)-enkephalin (DADL) in combination. The effects are thought to be mediated via opioid receptors since they are naloxone-reversible. Although inhibitors of the enkephalin degrading puromycin-insensitive, bestatin-sensitive aminopeptidase (possibly aminopeptidase M) their action is weak (IC50 = 32 microM leucine, 536 microM, glycine) and they might be considered to have a direct antinociceptive effect on opioid receptors. The titled compounds constitute novel 'lead' compounds for the development of potent aminopeptidase M inhibitors.