[Clinical observation on gastrointestinal protective effect of Composite Salviae injection in patients undergoing cardio-pulmonary bypass heart surgery].
OBJECTIVE: To observe the gastrointestinal protective effect of Composite Salviae Injection (CSI) in patients undergoing cardio-pulmonary bypass (CPB) heart surgery. METHODS: Eighteen patients, who were scheduled to cardiac surgery (either atrial or ventrical septal repairing) undergoing CPB were randomized equally into two groups. Before CPB, the CSI group was treated with CSI 0.5 ml/kg by intravenous dripping and the control group was treated with normal saline in equal volume. The intragastric mucosa pH value (pHi) of patients was monitored by tensiometer. RESULTS: As compared with the pre-CPB value, pHi lowered significantly during, 1 h and 2 hrs after CPB in the control group (P < 0.05 or P < 0.01), while in the CSI group, pHi lowered significantly only during CPB (P < 0.05), but with insignificant change at 1 h and 2 hrs after CPB. Comparison between the two groups showed that pHi value in the CSI group was higher significantly than that in the control group at all respective monitoring period (P < 0.05). CONCLUSION: CSI has gastrointestinal protective effect in patients undergoing CPB cardiosurgery to some extent.