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Biomedical subjects

Z Wu

Publications and source records attributed to Z Wu.

At least 631 records · Page 35Linked to original sources
PubMed1995

Clinical studies of primary angle closure glaucoma.

The ocular anatomic features, pupil-blocking force, status of angle synechia closure and positivity of provocative tests were compared between the primary chronic angle closure glaucoma (PCACG) and primary acute angle closure glaucoma (PAACG) by ultrasonic biometry, computerized image processing technique of the anterior ocular segment, gonioscopy and provocative tests. The studies showed that the anterior chamber depth of PAACG was shallower than that of PCACG, the pupil-blocking force of PAACG was stronger than that of PCACG, the status of angle synechia closure of PCACG was mainly creeping synechia closure and the positivity of mydriasis test after iridectomy was much higher (37.93%) in PCACG than that (11.43%) in PAACG. These facts suggested that the mechanisms of the angle closure of more than half of PCACG cases be multiple, besides the mechanism of pupillary block. Therefore, the authors emphasize that the pupillary block must be eliminated as well as the other mechanisms for the treatment of PCACG. The criteria of diagnosis and principles of management of PCACG were proposed.

Adult↗
PubMed1995

[Evaluation of the prognosis of critically ill surgical patients by APACHE II score system].

A prospective trial was conducted in 386 critically ill surgical patients, the APACHE II score was used to quantify the severity of illness and to judge the outcome. Admission APACHE II score of these patients averaged 15.6 +/- 5.4, the mortality rates rose from 1.9% to 100% when the APACHE II score increased from 0 to 38. The score was closely correlated with the subsequent risk of hospital death for these patients (r = 0.75 P < 0.001). Critically ill surgical patients would be well served by APACHE II for quality assurance or outcome.

APACHE↗
PubMed1995

[Characteristics and recent trends in endemicity of human parasitic diseases in China].

An analysis of the nationwide survey of the distribution of human parasites in the light of the literature previously published, two major trends in the endemicity of parasitic diseases in China was observed. For one trend, the infection rate of E. histolytica, Fasciolopsis buski and soil-transmitted helminthasis etc. declined markedly. The second trend was that the prevalence of food-transmitted parasitic diseases (Trichinella spiralis, Clonorchis sinensis, Paragonimiasis, cysticercosis) and hydatidosis was increasing. The relationship between the social economic factors and the two trends were discussed.

Animals↗
PubMed1995

[The preliminary study of insulin resistance in pregnancy induced hypertension].

OBJECTIVE: To observe the changes of glucose metabolism in late pregnancy and to reveal the relationship between insulin resistance and pregnancy induced hypertension (PIH). METHODS: The 75g oral glucose tolerance test (OGTT) was performed in 30 cases with PIH (37-41 weeks gestation), 30 cases of normal pregnancy and 12 non-pregnant women. The levels of serum glucose, insulin and C-peptide were measured by radioimmunoassay, and the areas under the curve (AUC) were calculated. RESULTS: There were significant increases of the peak level or AUC of insulin in PIH (61.42 +/- 48.72, 137.12 +/- 81.12 mIU/L) and in normal pregnant group (70.46 +/- 58.42, 150.37 +/- 104.76 mIU/L) compared with non-pregnant controls (17.12 +/- 11.03, 34.38 +/- 16.01 mIU/L) (P < 0.01), however, they had a similar glucose levels before or after GTT (P > 0.05). Furthermore, there was no correlationship between systolic or diastolic blood pressure and the fasting insulin or the AUC. CONCLUSIONS: Insulin resistance and hyperinsulinemia were found in late pregnancy, but the changes of insulin resistance in PIH cases was not significant. So, there was no definitive relationship between insulin resistance and the rising of blood bressure of PIH.

Adult↗
PubMed1995

Restriction fragment length polymorphism (RFLP) analysis of genomic DNA of 5 strains of Trichinella spiralis in China.

Five restriction endonucleases were used to digest genomic DNA from 5 isolates of Trichinella spiralis obtained from Changchun, Tianjin, Xian, Henan and Yunnan. All the isolates were secured from pigs except the Changchun strain which came from dog. The DNA fragments digested by endonuclease were separated by agarose gel electrophoresis. The Changchun isolate had a EcoRI band at 1.12kb and a DraI band at 1.97kb which were unique to this isolate. A cloned specific repetitive DNA sequence (1.12kb) from the Changchun strain was selected to prepare a probe for the Southern blotting of EcoRI restriction DNA fragments for the 5 isolates. The 1.12kb hybridizing band did not appear except in the Changchun isolate. These results seem to indicate that there are differences between the isolates obtained from hosts in different geographical regions.

Animals↗
PubMed1995

[A double-blind parallel group study of beclomethasone dipropoinate nasal spray of two different sources in the treatment of allergic rhinitis].

In order to compare the clinical efficacy and safety of beclomethasone dipropionate nasal spray (BDNS) manufactured in Chongqing Glaxo Limited (Group A) and Glaxo UK (Group B), a randomised double-blind parallel group study was performed. A total of 204 patients with seasonal or perennial allergic rhinitis were recruited into the study for a period of 2 weeks. Overall efficacy (excellent/good) was 88% for Group A (excellent 55%) and 90% for Group B (excellent 51%) respectively. Side effects were similar for both groups where dry nose was the most common complaint (4.9% for both groups). However, there was no statistical difference (P > 0.05) between the two groups either in efficacy or side effects. Pollen count was monitored throughout the study period. Pollen season was divided into three periods, i.e. the beginning, the peak and the end. There was no statistical difference (P > 0.05) between the two groups in any period.

Administration, Intranasal↗
PubMed1995

[Experimental study on the arteriovenous reversal for revascularization of ischemic brain].

Twenty-eight New Zealand white rabbits were randomly divided into experimental group (n = 20) and control group (n = 8). In the experimental group, the bilateral common carotid arteries were ligated, the blodd flow of right common carotid artery was reversed into the right cephalic internal jugular vein distal to the facial common vein, and the arterial and venous blood were obtained from the cerebral circulation pre and postoperatively for blood gas analysis. While in the control group, only the bilateral common carotid arteries were ligated. Both experimental group and control group were further divided equally into 4 subgroups for histological study at the 48th hour and on the 14th day after operation, cerebral angiography and ink injection on the 14th day of postoperation, and long survival observation, respectively. The results showed that all the animals survived. In the experimental group, the blood gas analysis revealed no statistical difference (P > 0.05) between pre- and postoperative. the cerebral circulation was rich and patent, and the cerebral cells were normal. In the control group, however, the cerebral blood flow was inadequate and the cerebral cells necrosed extensively. It is concluded that the adequate revascularization of ischemic brain can be created by the arteriovenous reversal.

Animals↗
PubMed1995

[Oxygen transport pattern in burned patient with sepsis under inotropic support].

Hemodynamic and oxygen-kinetic data of 16 burn patients with sepsis were analysed to explore relationship between oxygen transport pattern and clinical outcome after dopamine and dobutamine therapy. Two patterns of oxygen transport were shown in the 16 patients. Of them, ten (62.5%) had optimal DO2 and VO2 values (model I), and six (37.5%) had lower DO2 and VO2 values than the optimal (model II). All of 6 patients with model II developed lactic acidosis, septic shock and MOF and died. Two of 10 patients in model I developed MOF, only one died. The results indicate that, in burn patient with sepsis, the decreased response of DO2 and VO2 to inotropic therapy suggests failure of tissue perfusion, oxygen extraction and utilization, and may possibly predict the outcome.

Adolescent↗
PubMed1995

[In situ expression of c-myc, N-ras during diethylnitrosamine induced hepatocarcinogenesis].

In order to investigate the action of oncogenes in experimental hepatocarcinogenesis, the expression of c-myc, N-ras and H-ras were studied during early and late stages of DENA induced hepatocarcinogenesis in rats by using in situ hybridization. The results showed that overexpression of c-myc and N-ras was presented in teh proliferation hepatocytes and alternated hepatocytes foci during the early stage of hepatocarcinogenase, and with the formation and progression of hyperplastic hepatocytic nodules, the overexpresion cells of both were increased and often accompanied each other. Overexpression of H-ras appeared in the middle stage of hepatocarcinogenesis. The data obtained indicate that the abnormal expression of N-ras and c-myc in the hepatocarcinogenesis is not only an earlier molecule event which may relate to the initiation of HCC, but also the molecular basis for the morphogenesis of HCC, and these two functions took synergically. However, the abnormal expression of H-ras may have a promotive effect on the development of preneoplastic lesions, and also suggests that the malignant transformation of hepatocyte needs the cooperation of multiple oncogenes.

Animals↗
PubMed1995

[Guinea pigs infected by bacterial dust aerosol of Bacillus tuberculosis].

There still is controversy over whether Bacillus tuberculosis could be spread by dust. For the purpose to illustrate the possible contagious route, guinea pigs were exposed to bacterial dust aerosol which was generated by mixing Bacillus tuberculosis H37Rv with dried dust. The percentage of the size of particles, diameter < 4 microns, was 5.1%. The density of bacteria in the dust aerosol was 386.7 cfu/L and the mass medium diameter (MMD) was 1.9 microns. On the 70 days after exposure, in the 3 minutes exposed group, positive reaction to OT test (1:20) was 2/7, culture of Bacillus tuberculosis was positive from lungs and spleen was 1/7, in the 18 minutes exposed group, 5/8 were positive for OT test, the positive culture found from lungs was 2/8 and from spleen 1/8. These results showed that Bacillus tuberculosis could be spread by bacterial aerosol.

Aerosols↗
PubMed1995

Dissolution of premarital cohabitation in Canada.

The rapid increase in the number of unmarried cohabiting couples, indicated by recent evidence, is crucial to our understanding of changing marriage patterns. The levels and patterns of entry into cohabitation have been well documented over the last two decades, but little is known about the outcomes of nonmarital cohabitation. In this study we examine two competing outcomes of cohabitation relationships: union separation and legalization of the union through marriage. Our results show that the hazard rate of union dissolution is affected particularly by gender, fertility status, partner's marital status, religion, age at start of cohabitation, year cohabitation commenced, and region.

Adult↗
PubMed1995

Historical total and respirable silica dust exposure levels in mines and pottery factories in China.

Historical exposure estimates of total dust and respirable silica were made in a recent nested case-referent study of lung cancer among mine and pottery workers in China. Exposure to total dust and respirable silica was assessed in 20 mines and 9 pottery factories. The average total dust concentration was 7.26 mg center dot m-3, with a range from 17.68 mg center dot m-3 in the 1950s to 3.85 mg center dot m-3 in the 1980s, while the average respirable silica dust was 1.22 mg center dot m-3, with a range from 3.89 mg center dot m-3 in the 1950s to 0.43 mg center dot m-3 in the 1980s. The highest respirable silica dust occurred in the underground mining operations (1.43 mg center dot m-3), particularly for manual drillers (9.03 mg center dot m-3). Among all facility types, tungsten mines had the highest respirable silica dust exposure (1.75 mg center dot m-3), while the lowest exposure occurred in copper-iron mines (0.32 mg center dot m-3).

Ceramics↗
PubMed1995

[Clinical application of MRI in ophthalmic field].

PURPOSE: To investigate the application of MRI in ocular diseases and analysis the character of MRI-s parameters in these diseases. METHODS: MRI was applied among 68 patients with neurophthalmic disorders, orbits diseases, and intraocular lensions. RESULTS: The position (location) and feature of the lesions were diagnosed with clinical analysis. CONCLUSION: MRI possesses the special value in the differentiation diagnosis of neurophthalmic disease, orbit disordes and intraocular conditions.

Adolescent↗
PubMed1995

[An analysis of causes of recurrence, matastasis and death of retinoblastoma].

PURPOSE: To discuss the relationship between diagnosis, treatment and recurrence, metastasis, death of Rb patients. METHODS: To analyse the data of 46 Rb patients treated in our center from July 1967 to May 1992, who had either recurrence, metastasis or died. RESULTS: The main factors affecting Rb prognosis are: 1 early or late diagnosis: 2 the mortality rate increased with the degree of optic nerve involvement: 3 involvement of orbit, cranial cavity and choroid by Rb; 4 clinically, secondary glaucoma often accompanied by optic nerve involvement. CONCLUSIONS: Delay in diagnosis and treatment will result in Rb recurrence, metastasis and death. Early diagnosis and treatment is very important for survival rate.

Child↗