[Skin tests, blood histamine level and eosinophilia in vascular headache].
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Biomedical subjects
Publications and source records attributed to Z Wiśniewska.
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The levels of IgA, IgM and IgG were determined by the method of Mancini in 72 cases of ischaemic brain strokes. Different immunoglobulin fractions showed different changes. The highest IgA level was observed in the first week after the onset of the disease, while that of IgM was highest between the 4th and the 6th weeks of the disease. IgG values were not different from those in controls. Besides laboratory investigations the material was analysed from the standpoint of clinical manifestations, location of lesions and outcome of the disease.
The authors analysed clinically 108 patients (61 males and 47 females), aged below 50 years treated at the department of neurology, because of acute cerebral ischaemia. Attention is called to risk factors such as arterial hypertension, heart disease, atherosclerosis, obesity and diabetes which may be the cause of earlier development of ischaemic changes in the central nervous system. In the analysed group in 18 cases cerebral thrombosis, in 23 cases embolism, in 31 cerebral circulatory failure were diagnosed. In 36 cases the cause could not have been established.
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An analysis of 617 cases of cerebral strokes was done, including 534 acute and 83 past ones treated in the years 1966-1972. The patients were divided into 4 groups: I -- cerebral haemorrhage, II -- cerebral embolism, III -- cerebral arterial thrombosis, IV -- failure of cerebral circulation. The classification was based on clinical criteria and in dying patients also on autopsy findings. ECG changes were analysed in all patients. In the acute period of stroke the greatest proportion of cases were cerebral arterial thrombosis (197 cases --37%) and in this group acute myocardial infarctions were most frequent. This group was followed by cases of acute cerebral circulatory failure (191 cases -- 35%). The electrocardiographic correlate of the cerebral changes were in this group signs of myocardial ischaemia (84 cases -- 15%). Cerebral embolism (134 cases -- 24%) was associated with arrhythmia (109 cases --19) of various origin. In the group of cerebral haemorrhages (95 cases -- 17%) no unequivocal ECG changes were observed. In all patients with myocardial infarction during cerebral stroke atheromatous changes of coronary arteries were present. No correlation was observed between the location of the cerebral focus and the type of electrocardiographic changes.
In 63 patients with brain ischaemia and 29 healthy subjects the rosette test was done and clinical observations were conducted parallelly. The percent of peripheral blood lymphocytes forming rosettes spontaneously was 53.7% in the group of patients, while in the control group it was 63.4%. The difference was statistically significant.
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The results of EMG investigations with pharmacological and functional tests are reported in a rare case of periodic muscular rigidity with spontaneous activity at rest mainly in shouldergirdle muscle. The aetiology of the syndrome is unknown.
The reported investigations were carried out in 99 cases. In 73 cases acute vascular diseases of the central nervous system were recognized, and 26 subjects served for control. In all cases the test of PHA-stimulated blastic transformation of the blastic index suggest reduced resistance of the organism and they may be group of patients was compared with the control group. The quantitative data were analysed statistically using the test of Student and the t T test of Student for paired samples. The obtained results showed that the proportion of lymphocytes undergoing blastic transformation after stimulation with PHA was in the control group 66.1% on the average, while in the group of patients it was decreased to 55.2%. These differences were significant statistically. The low values of the blastic index suggest reduced resistance of the organism and they may be used as a valuable indicator informing about the resistance of the patient.
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In 70 cases of ischaemic brain strokes and 25 cases serving as a reference group the levels of immunoglobulin A, M, G were determined in the cerebrospinal fluid. The obtained results demonstrated that in the studied group the mean levels of IgA and IgM and total protein were increased in the cerebrospinal fluid. The value of IgG was unchanged in relation to the control group. The rise in the mean levels of IgA and IgM was not always parallel with the rise in the total protein level. The authors discuss the importance of blood-brain barrier. Its role seems plausible in cases with raised levels of immunoglobulins and total protein. These changes in the levels of immunoglobulins can be a result of various concomitant local and systemic factors.