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Biomedical subjects

Z Weshler

Publications and source records attributed to Z Weshler.

At least 55 records · Page 3Linked to original sources
PubMed1984

Bile duct tumours: prolonged survival by radiological management of T-tubes.

Carcinoma of the common bile duct is generally a slow-growing tumour which causes death by hepatic failure and ascending cholangitis secondary to obstruction. Internal drainage by surgical placement of a T-tube bypassing the tumour is widely employed, but survival times are generally short, averaging 9.9 months. The interventional radiologist can offer considerable prolongation of life with reduced hospitalization by means of percutaneous tube cleaning and catheter replacement. A case is presented where survival has been prolonged to 37 months by routine radiological catheter care.

Adenocarcinoma↗
PubMed1984

Production of systemic hyperthermia in the rat.

The design of clinical trials employing whole-body hyperthermia in cancer therapy has been hampered due to lack of a suitable animal model. We describe a technique for reproducibly and efficiently inducing whole-body hyperthermia in Sprague-Dawley rats, using halothane and oxygen anesthesia and immersion in a hot water bath. Core body temperatures of between 41.5 and 43 degrees C were induced and maintained for periods of up to 200 min and survival curves were determined. The time of exposure at a given temperature that resulted in death in 50% of the animals within 24 hr after heating (LD50/24 hr) was calculated by linear logistic regression analysis. LD50 24 hr values of 115, 61, 57, 25 and 16 min were obtained for temperatures of 41.75, 42.0, 42.25, 42.5 and 42.75 degrees C respectively. This heating technique is compared to several more toxic methods for inducing whole-body hyperthermia with respect to possible pharmacological and physiological differences.

Anesthesia, Inhalation↗
PubMed1984

Development and decay of systemic thermotolerance in rats.

The development and decay of thermotolerance to the lethal effect of systemic hyperthermia were investigated in Sprague-Dawley rats. Systemic hyperthermia was induced by partial submersion of gas-anesthetized rats in a controlled-temperature water bath. Survival was determined for rats challenged for periods of 10 to 90 min at 42.5 degrees at intervals of 24 to 144 hr after a sublethal conditioning exposure of 41.8 degrees for 1 hr. Survival curves and times of exposure at 42.5 degrees lethal to 50% of the animals (LD50) were determined for the conditioned animals and compared with those obtained for simultaneously treated control (unconditioned) rats. The thermotolerance ratios (LD50 for conditioned animals at various times after sublethal conditioning exposure divided by the LD50 for the control animals) were calculated and compared with the ratios reported in the literature for cells heated in vitro or for tissues heated locally in vivo. Pretreatment of rats at 41.8 degrees for 1 hr resulted in an increase in the LD50 for rats challenged 24 to 96 hr later, with a maximum increase noted at 48 hr (56.5 min compared with 25 min for control; thermotolerance ratio, 2.3). The animals remained relatively resistant to the second heat treatment at 96 hr and returned to control levels of heat sensitivity by 120 hr. The development and kinetics of thermotolerance to lethality induced by wholebody hyperthermia need to be considered in the design of multiple-fraction treatment plans.

Animals↗
PubMed1983

[Hansen's disease and cancer].

The number of patients treated for hanseniasis and cancer in Israel is not sufficient for a statistical analysis. A general conclusion about the incidence of cancer in hanseniasis patients has not been reached. The data presented may be perhaps useful for a comparison with those of other researchers interested in the subject.

Adult↗
PubMed1983

Radiation induced carcinoma of the middle ear.

Radiation induced carcinoma of the middle ear is rare. Only four cases have been reported; an additional case is now described. The treatment approach for radiation induced carcinoma of the middle ear has not yet been established. Radiation therapy for advanced cases is discussed as an alternative to surgical treatment. Previous reported cases are reviewed.

Aged↗
PubMed1982

Pericardial effusion as first evidence of malignancy in bronchogenic carcinoma.

Two patients in whom the development of a malignant pericardial effusion lead to the diagnosis of an unsuspected bronchogenic carcinoma are presented. Pericardial involvement has rarely been described as the first manifestation of an underlying lung tumor. Histologic type in both cases was adenocarcinoma, the most commonly described pattern in this situation. In concurrence with previous reports, prognosis of patients with malignant pericardial effusion remains poor.

Adenocarcinoma↗
PubMed1980

Bronchial malignant melanoma.

We describe a case of malignant melanoma presenting initially as an endobronchial lesion located in the left main bronchus causing total atelectasis. This resolved with radiation therapy. Widespread metastases developed shortly thereafter. The differential diagnosis of primary and metastatic bronchial malignant melanoma is discussed. Other isolated case reports are reviewed.

Bronchial Neoplasms↗
PubMed1980

Contrast mammography and the diagnosis of male breast cysts.

Solitary, large male breast cysts are extremely rare. They occur mainly in children up to the age of seven, with the maximum incidence in the first 2 1/2 years of life (Chumachenko, 1968). Pneumocystography and pneumomammography are very useful tools to diagnose cystic breast disease in females and to differentiate this entity from other breast diseases (Baraldi, 1935; Gross, 1952; Weshler et al., 1973). In males, the use of these diagnostic procedures has not been reported. In the present paper, we describe two cases of solitary breast cysts in males aged 11 and 35 in whom the diagnosis was established with the above mentioned procedures.

Adult↗
PubMed1978

Development of Hodgkin's disease in a patient with leprosy.

We present a patient with leprosy who developed Hodgkin's disease of the nodular sclerosing type. There are two previous reports describing the combination of leprosy and Hodgkin's disease in a single patient [3, 9]. Hodgkin's disease was diagnosed 14 months after the complete disappearance of mycobacterium leprae from the skin lesions, under treatment with DDS (diamino-diphenyl-sulfone). Hodgkin's disease was treated by irradiation and chemotherapy. Obstructive jaundice developed which resolved under treatment by irradiation of the hilar area of the liver, chemotherapy and hormones. During two years of immuno-suppressive therapy, without DDS, no exacerbation of the leprosy occurred.

Adult↗