Biomedical subjects
Z Wajda
Publications and source records attributed to Z Wajda.
[Effect of torecan on vomiting in postoperative period].
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[2-stage post-traumatic rupture of the aorta].
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[Recurrent ulceration of the stomach in the course of pancreatic adenoma].
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[Cardiac pacemakers and their implantation. Indications and results].
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[Personal experiences with implantation of electric pacemakers].
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[Anesthesia during implantation of electric cardiac pacemakers].
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[Late results of cardiac electrostimulation in patients with Morgagni-Adams-Stokes syndrome].
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[Management of Mortgagni-Adams-Stokes syndrome by epicardial and intraventricular electric stimulation].
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[Controlled drainage of the common bile duct].
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[Late results of surgical treatment of gastric cancer].
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[Advanced liver cirrhosis treated by means of dislocation of the spleen into the pleural cavity].
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[A complication of amebic abscess of the liver].
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[Defibrination syndrome due to surgery].
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[Shock and the defibrination syndrome according to studies on the fibrinolytic system].
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[Incarceration of diaphragmatic hernia].
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Determination of the condition of vascularization of pedicle skin grafts (Gillies-Filatov) by the thermoelement.
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Does nitric oxide protect from microcirculatory disturbances in experimental acute pancreatitis in rats?
The aim of the study was to investigate the potential role of nitric oxide (NO) on the microcirculation in experimental acute pancreatitis in rats. Twenty-five rats were divided into the following groups: group A (5 rats) = control; group B (5 rats) = acute pancreatitis induced by retrograde taurocholate infusion into the pancreatobiliary duct without treatment; group C (5 rats) = acute pancreatitis treated with the NO donor L-arginine; group D (5 rats) = acute pancreatitis treated with the NO synthase inhibitor N-nitro-L-arginine (L-NNA); group E (5 rats) = without pancreatitis receiving L-NNA. The animals were observed throughout 4 h. The microcirculatory values of the pancreas, liver, colon, stomach and kidney were measured by means of laser Doppler flowmetry. Three animals of group D died after the third hour of the experiment. In rats with pancreatitis, a rapid decrease in microcirculatory values was observed. The most pronounced drop in capillary blood flow within all the organs was observed in rats treated with the NO synthase inhibitor L-NNA, L-arginine administration in rats with acute pancreatitis slightly improved the microcirculatory values, although the improvement was significant in colon perfusion only. We conclude that NO may have a beneficial influence on the capillary organ perfusion in acute pancreatitis. The administration of an NO synthase inhibitor seems to have a detrimental effect on acute pancreatitis.