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Biomedical subjects

Z Vlodaver

Publications and source records attributed to Z Vlodaver.

46 records · Page 3Linked to original sources
PubMedDate not supplied

The biocompatibility of compressed collagen foam plugs.

The tissue reaction to reexpanded, purified bovine collagen sponge placed percutaneously into the lung, pleural space, liver, kidney, and muscle was studied in dogs and rabbits. In addition, the biocompatibility and radiopacity of tantalum-treated collagen foam plugs was examined. No adverse effects were found. We believe that collagen plugs may be of use in occluding needle tracts from biopsy sites to prevent complications such as bleeding or pneumothoraces.

Animals↗
PubMedDate not supplied

A stepless needle-dilator for expedient percutaneous catheterization: technical note.

A new stepless needle-dilator is described which allows arterial puncture and dilation in a single step using a single wall puncture technique. The new needle-dilator causes significantly less arterial damage than a conventional dilator (p less than 0.05). Additionally, time and cost savings are realized by clinical users.

Angiography↗
PubMedDate not supplied

In vitro and in vivo experimental evaluation of a new vena caval filter.

PURPOSE: A new stainless steel (MP35N alloy) vena cava filter without a central stasis point was evaluated in vitro and in vivo. MATERIALS AND METHODS: The clot-trapping efficiency and hemodynamic flow pattern of the filter were assessed in a flow model and were compared with those of currently available commercial filters including the Vena Tech-LGM, Simon nitinol, Greenfield, and Bird's Nest filters. The new filter was placed in the inferior vena cava (IVC) of 31 dogs; 21 of the 31 dogs were followed up with cavography for up to 3 months. At the termination of the study, the filters and IVCs were examined grossly and histologically. An in vivo clot-trapping test was carried out in five dogs. RESULTS: The least turbulence was noted with the new filter and the titanium Greenfield filter. The stainless steel Greenfield and Simon nitinol filters caused major flow disturbances. Migration within 5 cm of initial placement occurred in two animals (9.5%). There were no IVC thromboses, perforations, or filter embolizations. An in vivo clot-trapping study showed an 80% efficiency for small thrombi (3 x 20 mm) and 100% efficiency for large thrombi (6 x 20 mm) with the new filter. The Simon and the new filter had the best clot-trapping capabilities. The Vena Tech-LGM and Bird's Nest filters were slightly inferior and the Greenfield filter demonstrated by far the lowest trapping capacity. CONCLUSION: The new vena cava filter is easily introduced percutaneously through a 12-F sheath and appears to be very promising due to its high filtering capability, low turbulence, nonmagnetic properties, good mechanical stability, and hypothrombogenicity. Clinical trials are warranted.

Alloys↗
PubMedDate not supplied

Experimental myocardial infarction in the closed-chest dog: a new technique.

The reliable and safe production of myocardial infarction in closed-chest animals is of paramount research interest. To date, the injection of particulate matter and the introduction of occlusive solid plugs have been described. Because of the limited size of the catheter, only small branches could be occluded, which resulted in a high incidence of mortality. A new simple technique is described that allows occlusion of a major coronary artery at a preselected site. An Ivalon (polyvinyl alcohol) plug compressed around the tip of an introducing wire is advanced through a selectively placed catheter into the coronary artery. It is felt in place for 5 minutes and assumes its original size upon contact with blood. Once the plug is re-expanded, the wire is withdrawn. The new technique was carried out successfully on nine dogs with no immediate fatality and myocardial infarction as demonstrated by cine ventriculography and histopathologic examination.

Animals↗