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Biomedical subjects

Z Tulassay

Publications and source records attributed to Z Tulassay.

At least 127 records · Page 7Linked to original sources
PubMed1988

[Combined antisecretory therapy in patients with duodenal ulcer].

The ulcer healing effect of the combination of pirenzepine and cimetidine was compared to the cimetidine monotherapy in 60 duodenal ulcer patients, in whom previous cimetidine monotherapy (at the dose of 1000 mg/day for 4 weeks) had not produced any healing effect. The study was conducted in a prospective, double blind, random fashion. In 30 patients the cimetidine monotherapy was continued at the dose of 1000 mg/day. The other 30 patients received the combination of pirenzepine (75 mg/day) and cimetidine (400 mg at bedtime). Endoscopy was carried out before and after 4 weeks therapy. In the cimetidine group the ulcers have been cured in 12 cases. The cure rate was higher with the combination therapy: control endoscopy showed healed ulcers in 24 patients in this group. The difference between the two groups is statistically significant (chi 2-Test: 10.0, p less than 0.001). These results indicated a higher effectiveness of the pirenzepine-cimetidine combination in duodenal ulcer patients who had not previously responded to cimetidine alone.

Adult↗
PubMed1988

Alterations of vasoconstrictor and sodium-regulating hormone systems in vascularly decompensated liver cirrhosis.

Plasma levels of atrial natriuretic peptide (ANP), aldosterone (PA), vasopressin (AVP), and the plasma renin activity (PRA) were examined in 15 vascularly decompensated patients suffering from liver cirrhosis, before and after administration of albumin and after a subsequent administration of furosemide. The initial ANP level was lower in 9 patients (group "A") and higher in 6 patients (group "B") than in healthy controls (Group "A": 19.5 +/- 3.0 fmol/ml; group "B": 36.7 +/- 3.9 fmol/ml; control: 25.8 +/- 2.4 fmol/ml). The initial PRA (4.4 +/- 1.0 ng AngI/ml/h) and AVP (8.5 +/- 1.5 pg/ml) activity in group "A" increased significantly compared to group "B" (PRA: 0.44 +/- 0.09; AVP: 4.1 +/- 0.5), indicating an intravascular volume depletion in group "A". Albumin infusion raised the urine and sodium excretion and the plasma concentration of ANP in group "A" but lowered in plasma levels of renin and vasopressin. The same parameters were not changed by albumin in group "B". Furosemide equally raised the urine flow rate and sodium excretion in both groups. Plasma ANP level depends on the intravascular volume, and the secondary change in its plasma concentration plays a considerable role in the retention of fluid and electrolytes in patients with cirrhosis. The increased intravascular volume in these patients depletes the fluid and electrolyte retention via the increase in ANP level.

Adult↗
PubMed1988

[Pirenzepine and cimetidine in the treatment of duodenal ulcer].

The efficacy of pirenzepin--of anticholinergic effect--and the H2-receptor blocking cimetidine has been studied in duodenal ulcer with random, double blind fashion. Recurrence examinations were carried out 6 and 12 months following the treatment. 50 patients were given pirenzepin and 50 cimetidine. The average age of the patients was 44.5 and 43.8 years respectively. Of them 60 (24 + 36) were men and 40 (26 + 14) women. At the start, 6 weeks following the start 6 and 12 months after the finishing of the treatment gastroscopy was performed. In the course of the six-week-long treatment 38 (76%) of the pirenzepin taking patients and 36 (72%) of the cimetidine taking patients recovered. No significant difference was found between the efficacy of the both treatments. In the respect of the half and one year recurrence, no significant difference was observed between the two patient groups. Ten of the patients taking pirenzepin and 4 of those taking cimetidine complained of side effects. Dryness of mouth, visual disturbance in the former group and constipation in the latter one. On the basis of the examinations both secretion inhibitors were found equally suitable for the therapy of duodenal ulcer.

Adult↗
PubMed1987

[Endoscopic diagnosis and therapy of benign stenosis of Vater's papilla].

Out of 921 endoscopic papillotomies (EPT) 110 (12%) were performed in patients with benign stenosis of the papilla of Vater. Among these patients were 96 after cholecystectomy and 14 with gallbladder in situ. The diagnostic aspects of the stenosis of papilla and the complications of EPT were investigated on the basis of these patients. The dilation of the bile ducts is not a specific criteria for the diagnosis of papilla-stenosis. Dilatation could develop after cholecystectomy despite the normal sphincter pressure. The complication rate in patients with stenosis of papilla of Vater is increased (13.6%) in comparison with the patients with biliary stones (8.8%). This can be account for the increased number of haemorrhage and cholangitis.

Ampulla of Vater↗
PubMed1987

[Seasonal disposition of gastroduodenal ulcer--legend or reality?].

The seasonal activity of peptic gastroduodenal ulcers was studied on the basis of 17,106 gastroduodenoscopies which were done during a 10 years period. The activity of gastric and duodenal ulcer was increased only in autumn; their number in spring did not deviate from the average. The frequency of bleeding in duodenal ulcers was increased in autumn, whereas the gastric ulcer-bleeding was detected in more patients during winter. According to this examination the regular spring-autumn periodicity is not typical for the peptic ulcer.

Cross-Sectional Studies↗
PubMed1987

[Endoscopic papillotomy in patients with the gallbladder in situ].

Out of 731 endoscopic papillotomies (EPT), 175 (24%) were performed in patients with gallbladders in place. Gallstones were detected in 91 cases both in the gallbladder and in the bile ducts. The EPT resulted in a symptomless condition in 44 of these cases without surgery. In 47 patients the cholecystectomy became necessary later and since the cholostasis ceased the surgery could be done among better conditions. The EPT is recommended also in patients with gallbladder in situ because the surgery will be for some of these patients after the EPT unnecessary. However in that condition the risk of acute cholecystitis increases after EPT.

Aged↗
PubMed1987

Endoscopy in the diagnosis and treatment of benign stenosis of the papilla of Vater.

Of 921 endoscopic sphincterotomies (EST) performed by the authors, 110 (12%) were done for benign stenosis of papilla of Vater. Based on these data, they consider the possibilities of endoscopic diagnosis and treatment in the stenosis of papilla. One of the conditions for the diagnosis of papilla stenosis is the detectability of dilated biliary tract by endoscopic retrograde cholangiography. But this cannot be taken as a specific sign because, e.g., the biliary tract may become dilated in spite of normal sphincter tone after gall-bladder removal. At the same time, biliary tract dilation is a diagnostic criterion for papilla stenosis, and abnormal findings in biliary scintigraphy and the laboratory syndrome consistent with cholestasis cannot be avoided. EST is the method of first choice in the treatment of papilla stenosis in comparison to surgery. The complications of EST, however, occur in papilla stenosis more frequently than in choledocholithiasis (8.8%). Bleeding and cholangitis are responsible for the excess incidence.

Ampulla of Vater↗
PubMed1985

[Endoscopic occlusion treatment in patients with chronic pancreatitis].

Between 1980 and 1983 an endoscopic occlusion of pancreatic duct was performed in 12 patients with chronic pancreatitis. In 4 patients it could be achieved a complete, in 8 patients only a partial occlusion. Four patients became free of pain whereas 5 patients have been operated on following an aggrevation of disease. After one year diabetes mellitus developed in 2 patients. We conclude that the endoscopic occlusion of the pancreatic duct may be recommended in some patients with defined diagnosis and special duct constellation.

Adult↗