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Biomedical subjects

Z Spirer

Publications and source records attributed to Z Spirer.

At least 109 records · Page 6Linked to original sources
PubMed1981

Selective IgA deficiency with multiple autoimmune disorders.

A case of an IgA deficient child who developed several autoimmune diseases namely, celiac disease, pernicious anemia, autoimmune thyroiditis and autoimmune thrombocytopenic purpura is reported; the possible connections and etiology of these phenomena is briefly discussed. Individuals with selective IgA deficiency should no longer be considered "normal".

Autoimmune Diseases↗
PubMed1980

Decreased serum tuftsin concentrations in sickle cell disease.

The serum concentrations of the phagocytosis-stimulating peptide, tuftsin, were determined by radioimmunoassay in 21 patients with sickle cell disease and in 12 healthy controls. The mean serum tuftsin concentration was significantly lower in patient with haemoglobin SS disease (154.3 +/- 35.1 ng/ml; 308.6 +/- 70.2 nmol/l, P < 0.01) and in patients with haemoglobin SC and CC disease (180.9 +/- 42.7 ng/ml; 361.8 +/- 85.4 nmol/l, P < 0.05) than in healthy controls (228.7 +/- 46.7 ng/ml; 457.4 +/- 93.4 nmol/1). Tuftsin deficiency is an indicator of splenic hypofunction and may contribute to the increased susceptibility of patients with sickle cell disease to severe infection.

Adolescent↗
PubMed1980

Autoimmune antibodies after splenectomy.

Sera of 41 splenectomized subjects were tested for presence of autoantibodies by the indirect immunofluorescent method. 11 of them (26%) revealed the presence of one or more types of autoantibodies. Antiheart antibodies were the most common type (9 subjects). The incidence of antibodies was higher in the subjects splenectomized for trauma than in those who underwent elective splenectomy (39 and 25%, respectively). There was no significant difference between the subjects with positive and negative results with respect to mean age at examination, but the positive results tend to occur more frequently in those who underwent splenectomy at younger age. None of the subjects with any type of antibodies suffered from autoimmune disease. Although it is still impossible to evaluate the clinical importance of these findings, they suggest that splenectomy may disturb the regulatory processes in the immune system. We postulate that this is due to the reduction of the number of suppressor T cells for which the spleen is a major pool.

Adolescent↗
PubMed1979

Decreased serum 24,25-dihydroxy vitamin D concentrations in children receiving chronic anticonvulsant therapy.

Serum 24,25-dihydroxy vitamin D (24,25(OH)2D) and 25-hydroxy vitamin D (25-OHD) concentrations and the ratio between the two were measured in 31 Israeli children and adolescents receiving long-term treatment with phenobarbitone or phenytoin and in controls. 24,25 (OH)2D concentrations were significantly depressed in the patients, although the 25-OHD concentrations were similar to those in the healthy controls. In four patients with radiological evidence of osteopenia very low serum 24,25(OH)2D concentrations and serum 24,25(OH)2D: 25-OHD ratios were recorded. The findings suggest that 24,25(OH)2D deficiency may play an important part in the pathogenesis of osteomalacia in patients treated with anticonvulsant drugs and provide further indirect evidence that 24,25(OH)2D is important for normal bone structure.

Adolescent↗
PubMed1979

Studies on the activity of phorbol myrystate acetate on the human polymorphonuclear leukocytes.

Phorbol myrystate acetate (PMA) activates nitroblue tetrazolium reduction in human polymorphs. The activation is inhibited by dibutyryl cyclic AMP, theophylline and phenylbutazone, but is not influenced by hydrocortisone in vitro, nor is it inhibited by leukocytes from patients treated with prednisone. Peptide analogues of Tuftsin also had no effect on this stimulatory activity. We conclude that the action of PMA on the nitroblue tetrazolium reduction is mediated through cyclic nucleotides.

Adult↗
PubMed1979

Response of neonatal hypocalcaemia to 1 alpha-hydroxyvitamin D3.

Administration of 1 alpha-OH-D3 to hypocalcaemic neonates (mean +/- SD, serum calcium 1.50 +/- 0.13 mmol/l) significantly increased serum calcium in all 24 infants within 48 hours after starting therapy (mean +/- SD 1.83 +/- 0.23 mmol/1). The time required to correct hypocalcaemia was significantly shorter (2.04 +/- 0.56 days) in infants treated with 1 alpha-OH-D3, than in 24 infants treated with calcium gluconate infusions (4.12 +/- 1.0 days). Treatment with 1 alpha-OH-D3 was effective, easy to maintain, and produced no side effects.

Calcium Gluconate↗
PubMed1979

[Reye's syndrome].

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Child, Preschool↗