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Biomedical subjects

Z Shen

Publications and source records attributed to Z Shen.

At least 343 records · Page 19Linked to original sources
PubMed1991

Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee).

A double-blind, crossover, 8-wk study was conducted to compare effects of the tocotrienol-enriched fraction of palm oil (200 mg palmvitee capsules/day) with those of 300 mg corn oil/d on serum lipids of hypercholesterolemic human subjects (serum cholesterol 6.21-8.02 mmol/L). Concentrations of serum total cholesterol (-15%), LDL cholesterol (-8%), Apo B (-10%), thromboxane (-25%), platelet factor 4 (-16%), and glucose (-12%) decreased significantly only in the 15 subjects given palmvitee during the initial 4 wk. The crossover confirmed these actions of palmvitee. There was a carry over effect of palmvitee. Serum cholesterol concentrations of seven hypercholesterolemic subjects (greater than 7.84 mmol/L) decreased 31% during a 4-wk period in which they were given 200 mg gamma-tocotrienol/d. This indicates that gamma-tocotrienol may be the most potent cholesterol inhibitor in palmvitee capsules. The results of this pilot study are very encouraging.

Adult↗
PubMed1991

Effects of PGE2 and a thromboxane A2 analogue on uptake of IgG complexes and LDL by mesangial cells.

Vasoactive agents such as angiotensin (ANG) and eicosanoids can influence macromolecular deposition in the glomerular mesangium. We studied whether prostaglandin E2 (PGE2) and U-46619 (a stable analogue of thromboxane A2) could directly affect the uptake of immunoglobulin G (IgG) complexes or low-density lipoprotein (LDL) by cultured rat mesangial cells (MC). Preincubation of MC with PGE2 (10(-6) M) resulted in decreased uptake (in counts.min-1.well-1) of IgG complexes (PGE2, 2,589 +/- 72; control, 3,840 +/- 114; P less than 0.001) and LDL particles (PGE2, 23,176 +/- 1,145; control, 37,216 +/- 4,520; P less than 0.05). MC preincubated with forskolin (10(-5) M) also showed decreased uptake of IgG complexes (forskolin, 2,896 +/- 196; control, 3,840 +/- 114; P less than 0.005) and LDL particles (forskolin, 23,176 +/- 1,145; control, 37,216 +/- 4,520; P less than 0.05). In contrast, preincubation with ANG II (5 x 10(-7) M) showed significantly higher uptake of IgG complexes (ANG II, 4,475 +/- 282; control, 3,787 +/- 277; P less than 0.05) and LDL (ANG II, 48,573 +/- 1,079; control, 44,697 +/- 770; P less than 0.05). Similarly, preincubation with U-46619 (10(-6) M) resulted in significantly higher uptake of IgG complexes (U-46619, 5,370 +/- 300; control, 3,659 +/- 307; P less than 0.02) and LDL (U-46619, 48,298 +/- 1,418; control, 44,697 +/- 770; P less than 0.05). After preincubation with cyclooxygenase inhibitor meclofenamate (10(-6) M), ANG II (5 x 10(-7) M) resulted in a significantly higher uptake of IgG complexes compared with uptake by MC treated with ANG II alone (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

1-Methyl-3-isobutylxanthine↗
PubMed1991

Effects of amobarbital on pterins and dinucleotides contents in rat brain.

The effects of amobarbital (50 mg.kg-1 ip) on the brain concentrations of biopterin, pterin, reduced nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) were studied by a reverse phase high performance liquid chromatography with fluorescent detector. Amobarbital increased FAD concentrations in 5 brain areas and pterin concentration in the cortex, but decreased biopterin concentrations in the cortex and hippocampus.

Amobarbital↗
PubMed1991

[An electron microscopic observation on laryngeal epithelium in human fetus and adults].

Seventeen specimens of laryngeal mucous membrane taken from 14 fetus (9-38 week), 1 newborn and 2 adults were studied with scanning and transmission electron microscopes. The results showed that the cilia of ciliated epithelium began to develop in the 9th week embryo and matured at the 17th week; the epithelium of vocal cord matured during the 9th week and showed squamous epithelium during the 14th week. In the transitional area the ciliated epithelium gradually transformed into squamous epithelium.

Adult↗
PubMed1990

Two-way shuttlebox avoidance conditioning and brain NADH in rats.

The effects of amphetamine (1.5 mg/kg) and caffeine (120 mg/kg, 75 mg/kg) on shuttle behavior and on the concentrations of reduced nicotinamide adenine dinucleotide (NADH) of the brain were studied in 56 rats from the perspective of regional brain metabolism. Amphetamine potentiated the shuttle behavior including avoidance responses and response speed, while it increased NADH concentrations in the hippocampus. The low dose of caffeine increased avoidance responses. The high dose of caffeine inhibited avoidance responses, but it had no effect on NADH concentrations in discrete brain regions.

Amphetamine↗