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Biomedical subjects

Z S Toktamysova

Publications and source records attributed to Z S Toktamysova.

12 recordsLinked to original sources
PubMed1990

[The sensitivity of erythrocytes to hemolysis in relation to the degree of hemoglobin oxidation].

Osmotic shock-induced hemolysis of red cells for the fresh and preserved blood was examined in order to determine the red cell sensitivity to hemolysis in relation to hemoglobin status. The obtained hemolysis curves suggest that hemolysis depends on the red cell hemoglobin status: a more oxidized hemoglobin is associated with an earlier onset of hemolysis. A protective effect of methylene blue with glucose on hemolysis was revealed. Basing on these data, the authors conclude that red cell sensitivity to hemolysis depends on the degree of hemoglobin oxidation.

Erythrocytes↗
PubMedDate not supplied

[Comparative study of the effect of phenazine methosulfate and vitamin K3 on human erythrocytes by hemolysis curves].

Hemolysis curves were used for comparative study of phenazine methylsulfate (PMS) and vitamin K3 action on human erythrocytes. Some differences in PMS and vitamin K3 action were revealed while the concentration of studied compounds and incubation time with them were changed. It is considered that the observed differences in PMS and vitamin K3 action are caused by different degree of oxidation of intracellular hemoglobin.

Erythrocytes↗
PubMedDate not supplied

[The effect of phenazine methosulfate on human erythrocytes].

The experimental data about the phenazine methosulfate (PMS) effect on human erythrocytes are considered. It is demonstrated that PMS well penetrates the cells and causes changes dependent on incubation time. PMS may possess either oxidative or reducing properties according to experimental conditions. The PMS potency for oxidation is revealed in change of the haemoglobin redox state to more oxidative one (MetHb), in decrease of the reducing glutathione level and in increase of the reducing rate of potassium ferricyanide (RRPF). The use of erythrocytes oxidated by sodium oxide demonstrates the PMS reducing properties which cause reduction of methaemoglobin (MetHb) and decrease of the sodium oxide inhibitory effect on RRPF. Based on the obtained data a scheme is proposed for the PMS action on erythrocytes implying three interaction centres within the cells.

Erythrocytes↗