Biomedical subjects

Z Pelikan

Publications and source records attributed to Z Pelikan.

At least 55 records · Page 3Linked to original sources

PubMed1983

The late bronchus-obstructive response to bronchial challenge with pigeon faeces and its correlation with precipitating antibodies (IgG) in the serum of patients having long-term contact with pigeons.

From a total of 160 patients with allergic bronchial asthma or chronic asthmatic bronchitis, eighteen (11.3%) patients reported being regularly exposed to pigeons. In these eighteen patients, bronchial provocation tests with pigeon faeces were performed and the precipitating antibodies (IgG) in their serum against pigeon faeces and serum were estimated. Of the eighteen patients, seven (39%) demonstrated a 'late bronchus-obstructive response' to pigeon faeces. Three patients developed only an 'isolated late response' and in the other four patients the late response occurred as a part of the 'dual response'. In the seven patients with the positive late bronchial response, the precipitating antibodies in their serum to pigeon faeces were positive in five (71%) and to pigeon serum in two (28%) of them. The late skin responses to pigeon faeces were positive in five (71%) patients, the blood eosinophilia increased in six (86%) of them, a slight pyrexia occurred in two (28%) and general malaise symptoms appeared in six (86%) of them. None of these patients developed changes on the chest X-ray during the late response. The remaining eleven patients did not develop any bronchial response to pigeon faeces challenge, although in six (55%) of them the late skin responses were positive, and two (18%) had precipitating antibodies in the serum to pigeon faeces and one (9%) to pigeon serum. It is concluded that positive precipitating antibodies in the serum to pigeon faeces and serum are important parameters for detection of pigeon breeder's disease in exposed individuals, however confirmation of this diagnosis should be provided by the bronchial provocation tests.

Adolescent↗

PubMed1983

A new disease: a nasal form of pigeon breeder's disease.

In 47 allergic rhinitis patients regularly exposed to pigeons, nasal provocation tests with pigeon dropping extracts, in combination with other parameters, were performed. Twenty-five of the 47 patients developed a late nasal response (LNR) to pigeon droppings (53%), six of them an isolated response and 19 a dual response (immediate + late). The precipitating antibodies to pigeon droppings were positive in 20 (80%) and to pigeon serum in nine LNR patients (36%). Late skin responses to pigeon droppings occurred in 15 (60%) and to pigeon serum in seven LNR patients (28%). In 13 patients (52%) general malaise, in seven (28%) increased blood eosinophilia, in nine (36%) increased body temperature and in 11 (44%) haemorrhages in the nasal mucosa were observed during the LNR. The results of this study provide evidence for the existence of a new disease, a nasal form of pigeon breeder's disease.

Adolescent↗

PubMed1983

The diagnostic approach to immediate hypersensitivity in patients with allergic rhinitis; a comparison of nasal challenges and serum rast.

Nasal challenges performed in 182 patients with allergic rhinitis revealed 273 positive and 125 negative responses to house dust, grass pollen, cat and dog danders and aspergillus fumigatus, which all correlated with disease history and intracutaneous tests. In these randomly selected patients the specific IgE antibodies in the serum to the same allergens as those used for nasal challenges were determined quantitatively by serum RAST. Additionally, blood and nasal eosinophilia were recorded during the nasal provocation tests. In all 273 positive challenges protection tests with disodium cromoglycate (DSCG) were also performed. In 24.2% of the positive nasal challenges serum RAST was found positive and in 18.7% of them serum RAST was doubtful. In 52% of the negative nasal challenges negative serum RAST also occurred. No significant correlation was found between serum RAST and nasal challenges (X2 = 0.92; d.f. = 1; 0.20 less than p less than 0.40). No significant correlation was found between serum RAST and nasal challenges for individual allergens tested. Since the nasal provocation test is an in vivo technique, it is likely to be of value for the diagnostic confirmation of the allergic component (due to immediate hypersensitivity) in patients with allergic rhinitis than serum RAST alone. Although serum RAST cannot substitute the nasal provocation tests, it may be a useful supplementary diagnostic parameter.

Humans↗

PubMed1982

The effects of disodium cromoglycate and beclomethasone dipropionate on the late nasal mucosa response to allergen challenge.

The protective effects of disodium cromoglycate (DSCG) and beclomethasone dipropionate (BDA) on the late nasal mucosa response to allergen challenge (LNR) were investigated in 42 patients with allergic rhinitis. The 42 patients, selected from a group of 370 patients, developed a total of 52 later nasal responses (LNR), 13 of which were isolated later responses (ILNR) and 29 of which were dual responses (DNR), i.e., where the later response (DLNR) has been preceded by an immediate response (INR). Significant protective effects on the immediate and on the late nasal mucosa responses were seen following the use of DSCG. The late response, being a part of the dual response was decreased by DSCG to a higher degree than the isolated late response. Although BDA also decreased the late response, the isolated late response was decreased to a greater degree than that demonstrated as a part of the dual response. The immediate response was not influenced by BDA at all. It is suggested that DSCG should be used as a drug of first choice to control the allergic rhinitis symptoms. However, in the presence of the later nasal response, BDA should be added, at least at the beginning of the treatment and during the period of peak exposure to allergen, i.e., the pollen season.

Administration, Intranasal↗

PubMed1982

The effects of disodium cromoglycate and beclomethasone dipropionate on the immediate response of the nasal mucosa to allergen challenge.

This study deals with the comparative investigation of the protective effects of disodium cromoglycate (DSCG) Rynacrom, Intal and beclomethasone dipropionate aerosol (BDA); Aldecin Beconase on the immediate nasal mucosa response to allergen challenge due to the immediate hypersensitivity (Type I allergy) in 50 patients suffering from allergic rhinitis. DSCG demonstrated distinct protective effects on the immediate nasal mucosa response to allergen challenge in all patients investigated, while BDA failed to demonstrate any protective effects on the immediate nasal mucosa response to allergen challenge in any of the patients studied.

Administration, Intranasal↗

PubMed1982

A diagnostic study of immediate hypersensitivity in asthmatic patients: a comparison of bronchial challenge and serum RAST.

The present study consisted of 124 patients with bronchial asthma or chronic asthmatic bronchitis due to immediate hypersensitivity (Type I allergy). A total of 329 bronchial challenges with house dust, grass pollen, cat and dog danders were performed in these patients who were randomly selected and the specific IgE antibodies in the serum to the same allergens were quantitatively determined (serum RAST). Of 329 bronchial challenges, 147 positive and 109 negative bronchial challenges correlated with intracutaneous tests and disease history (77.8%). In the group of 147 "positive correlating bronchial challenges" (positive challenges, positive skin tests, positive histories), 29.9% showed as positive serum RAST while 50.3% were RAST plus doubtful. In the group of 109 "negative correlating bronchial challenges" (negative challenges, negative skin tests, negative histories), negative serum RAST was found in 51.4% cases. The over-all correlation between the serum RAST and the "correlating bronchial challenges" (chi 2 = 5.19; d.f. = 2; 0.05 less than p less than 0.10) as well as the correlation for the individual allergens were found to be non-significant. It is concluded that bronchial challenges with allergens, being an in vivo parameter, are of a greater value for the diagnostic confirmation of the allergic component due to the immediate hypersensitivity (Type I allergy) in asthmatics than the serum RAST, being only a useful in vitro supplementary parameter. Serum RAST cannot substitute the bronchial challenges generally, only in some special cases.

Asthma↗

PubMed1979

Effect of histamine on respiratory movements and isolated ileum of pertussis-vaccinated mice. A negative study.

1. The sensitivity of mice, of the Swiss random bred strain, previously i.p. vaccinated with Bordetella pertussis Phase I cells, to histamine was investigated. 2. No response and no increase of the sensitivity of the respiratory system of the pertussis-vaccinated mice was observed during and after the inhaled histamine. 3. No contractions and no response of the isolated perfused ileum of the pertussis-vaccinated mice were observed after the addition of histamine. 4. No experimental or control mouse died during the whole experiment.

Aerosols↗

PubMed1978

Possible immediate hypersensitivity reaction of the nasal mucosa to oral contraceptives.

Nasal provocation tests with suspension of oral contraceptive drugs (OCD) as well as of their components (Estrogen, Progestin, Non-hormonal components) were performed in two groups of women, mostly suffering from perennial rhinitis or pollinosis, and all taking oral contraceptive drugs. Thirteen of the 15 patients from the first experimental group, in whom the increase of the nasal complaints was anamnestically related to the oral contraception, and three of the 34 patients from the second experimental group (without anamnestical relation to the oral contraception) demonstrated a positive nasal mucosa response after topical challenge with OCD. All OCD positively reacting patients showed also a positive nasal mucosa response after challenge with the Estrogen and one patient also after Progestin challenge. Non-hormonal components did not cause any reaction. This nasal mucosa response was interpreted as a possible allergic reaction. Type I (immedicate hypersensitivity of the nasal mucosa due to Estrogen in blood contraceptives. This response begins within 10 minutes, reaches its maximum within 30 minutes, and does not disappear completely within 60 minutes in most patients. None of the patients from control groups (atopy--without OCD; OCD takers--without atopy; male volunteers without atopy) demonstrated any positive nasal mucosa response to OCD or their components.

Contraceptives, Oral↗

PubMed1978

Late and delayed responses of the nasal mucosa to allergen challenge.

In 600 patients suffering from allergic rhinitis the possible existence of another type of allergic reaction of the nasal mucosa other than Type I (immediate) was investigated by means of nasal provocation tests with allergens. Late response of the nasal mucosa to allergen challenge indicated that Type III hypersensitivity might be involved. Delayed reactions also made Type IV suspect.

Adolescent↗

PubMed1977

Response of the nasal mucosa to allergen challenge measured by two different methods of rhinomanometry.

Nasal provocation tests with allergen (House Dust 5.0 mg/ml or Grass-Pollen 10000 Noon Units/ml) were performed on patients suffering from perennial rhinitis or pollinosis. The changes of the nasal passages before and after allergen challenge were measured by two different methods, (1) the rhinomanometry anterior (Balloon Method) and (2) the rhinomanometry posterior (V-P Method). No distinct differences were observed between results obtained by the two methods. Both are therefore considered suitable and applicable for nasal provocation tests. For a satisfactory result using both techniques, the measurements should be made within at least 30 minutes but preferably 60 minutes after the allergen challenge.

Adult↗

PubMed1974