[Evaluation of renal function in lipoid nephrosis in children according to clearance indicators].
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Biomedical subjects
Publications and source records attributed to Z Morawska.
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Actual knowledge on the HLA relationship with the primary glomerulopathies, with particular reference to steroid - sensitive nephrosis of childhood, is surveyed. Occurrence of HLA B-8 and B-35 in this nephropathy has been investigated. The studies involved 47 patients aged between 3 and 15 years and 117 healthy children from Lower Silesian region. It has been showed, that HLA B-8 is present more frequently in sick children, than in healthy controls. The situation is reverse in case of HLA B-35 antigen. However, the difference is statistically insignificant. A probability of the lipid nephrosis sensitivity to corticosteroids can not be predicted on the base of the presence of these HLA antigens.
Serum and erythrocyte zinc levels have been assayed in in 45 children with steroid-dependent nephrotic syndrome in both acute phase and remission. Out of these children a group of 22 has been distinguished. These patients have been treated with Livex--animal blood preparation containing amino acids and trace elements, including zinc. It was found, that serum zinc has been significantly lowered in children with the acute phase of nephrotic syndrome who were not treated with Livex. Erythrocyte zinc levels have been normal in these patients. A significant increase in both serum and erythrocyte zinc levels has been noted during remission, but they have still been lower that in healthy children. A three-month cure with Livex produced statistically significant increase in zinc levels in children during remission.
Six hundred forty seven children with genito-urinary tract abnormalities selected from the group of 1,423 children with urinary infections have been analysed. Prevailing contribution of the genito-urinary tract abnormalities to the development of chronic renal failure has been emphasized. It has been shown, that diagnostic problems and delayed treatment are most frequently due to non-characteristic and oligosymptomatic course of the disease. Proper approach to the genito-urinary tract abnormalities symptomatology accompanied with proper diagnosis and management may significantly lower the incidence of severe renal failure.
Activity of alanine aminopeptidase (AAP), beta-glucuronidase, and N-acetyl-beta-D-glucosaminidase (NAG) in daily urine has been determined in 27 children with nephrotic syndrome, 14 children in remission, and 11 healthy children. It was found, that these enzymes activity is significantly increased in sick children in comparison with healthy ones. Similarly, the activity of AAP and NAG in daily urine is statistically significantly higher in children with remission, than that in healthy children. An assay of these enzymes in the urine may be used in the diagnosis of nephrotic syndrome and in the evaluation of its course.
A rare is reported of superimposition of IgA nephropathy upon membranaceous glomerulonephritis in a boy aged 13 months with fatal outcome. Attention is called to unresponsiveness of the disease to the trials of treatment, high dynamics of inflammatory changes and rapidly progressing impairment of renal function.
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