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Biomedical subjects

Z Mijusković

Publications and source records attributed to Z Mijusković.

13 recordsLinked to original sources
PubMedDate not supplied

[Immunochemical findings in the cerebrospinal fluid in patients with inflammatory demyelinating polyradiculoneuropathy].

The aim of the study was to check the hypothesis of involvement of the structure of the central nervous system on the basis of the analysis of the integrity of blood-brain barrier and the degree of IgG synthesis in the intrathecal space of patients with inflammatory demyelinization polyradiculoneuropathy. The study involved 27 patients with acute and 14 patients with chronic inflammatory demyelinization polyradiculoneuropathy. The analysis of liquor was performed in different stages of the disease. The results have shown that in the acute phase, in the phase of the maximal functional deficit there are signs of damaged integrity of the blood-brain barrier but without signs of increased intrathecal IgG synthesis. It has been concluded that there are no reliable signs of increased immunologic activity in the intrathecal space of patients with inflammatory demyelinization polyradiculoneuropathy.

Adult↗
PubMedDate not supplied

[The importance of using various methods in the determination of serum immune complex levels].

Concentration of immune complexes (IC) in the serum of patients with various diseases (glomerulonephritis systemic lupus erythematosus--SLE, rheumatoid arthritis--RA and with positive antibodies to human immunodeficiency virus--HIV+) has been determined using two methods: PEG precipitation and laser nephelometry (NL) of binding to Latex = C1 12q complement components in aqueous media. The presence of antiimmunoglobulin antibodies, that is, rheumatoid factor (RF) and its eventual effect on the precision of measurement of IC using LN C1q method has been determined by LN-Latex RF method. The results have shown that the increased IC values obtained by one method can be within physiological levels if the other method was applied and vice versa. Depending on the group of examinees such negative correlation ranged from 33% to 64%. This is the result of already known limitations of the studied methods and confirms the necessity of simultaneous application of different methods for determination of IC concentration. Regardless of anticomplementary activity of serum rheumatoid factor its presence in the serum has not shown to have any effect on the precision of determination of IC concentration using IC by LN- C1q method.

Antigen-Antibody Complex↗
PubMedDate not supplied

[Endemic nephropathy in the region of Bela Crkva in Banat].

The village of Kusić is situated 8 km southwestern of Bela Crkva, at the very border, separated from Romania by the river Nera. Due to frequent disease occurrence in the village Kusić, the pelustration of population was done in 1978 and 1989, and during the later follow-up, many patients were examined either in hospital or in outpatient clinics. The aim was to confirm a suspicion on the existence of the focus of endemic nephropathy in the village of Kusić. In 1978 and 1989 abnormal proteinuria was found in 17.7% and 16.7% examines from the village of Kusić, respectively-significantly higher than in surrounding villages: Grebenac, Vracev Gaj, Banatska Palanka and Kruscica (p < 0.01). Slow progression to the lasser degree of anemia was found in the patients with proteinuria, compared to the control group. Eight of 10 regularly dialyzed patients died, and in 4 patients urothelial carcinoma was diagnosed. In all of them nephroureterectomy was performed, and one patient with advanced disease died 6 months after surgery. On the basis of cited data, by their comparison and further prospective observation of the patients from the village of Kusić, it was concluded that the new focus of endemic nephropathy existed in southeastern Banat.

Adolescent↗
PubMedDate not supplied

[IgA nephropathy--IgA1 disease].

The aim of this study was to prove the increased IgA1 production in patients with IgA nephropathy compared to the control group of healthy subjects, by determination of serum subclasses IgA, IgA1 and IgA2 levels. That with the exclusive presence of IgA1 in kidney tissue, justified the assertion that IgAN was IgA1 disease. Eighteen patients with IgA nephropathy, 15 male and 3 female, average age 17-54 (mean +/- SD = 34.1 +/- 5.18) were included in the prospective study. The diagnosis was proved by immunofluorescent assay of bioptic kidney material obtained by ultrasonically guided biopsy. The total serum IgA and IgA1 and IgA2 subclasses levels were determined in the patients and healthy conscripts from the control group. The methods of immunonephelometry and radial immunodiffusion were used. Increased IgA values were found in 22.75% and of IgA1 subclass in 38.85% patients. Patients with IgA nephropathy had significantly higher IgA1 values (p < 0.01), compared to the control group. There was no significant difference in IgA2 subclass levels. Renal function did not significantly affect IgA1 and IgA2 subclasses values.

Adolescent↗