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Biomedical subjects

Z Luo

Publications and source records attributed to Z Luo.

188 records · Page 11Linked to original sources
PubMed1990

[Vegetative nervous function and interleukin-2 receptor in patients with vertigo].

The authors used Wenger's vegetative nervous balance factor analysis to measure vegetative nervous function of 75 patients with vertigo revealing enhancement of sympathetic nervous function. The proliferation activity of IL-2 receptor was determined by the amount of 3H-TdR incorporated cpm in the peripheral blood lymphocyte after exogenous IL-2 stimulation (Lymphocult-T). The authors used this technique to measure the activity of IL-2 receptor in 49 patients with hepatitis and vertigo. The results showed that the activity of IL-2 receptor in patients with or without vertigo was lower than the controls (P less than 0.001). And patients with vertigo showed lower activity of IL-2 receptor than that without (P less than 0.01). In these patients with asthenia-syndrome the activity of IL-2 receptor was lower than those with asthenia syndrome. The activity of IL-2 receptor in these patients with long course was lower than those with short course. The difference of sex and age was not significant. The above results suggest that "Wind" in TCM might be related to the enhancement of sympathetic nervous function and the activity of IL-2 receptor.

Adolescent↗
PubMed1988

Cross-sectional analysis of serum antibody to oral streptococcal antigens in children.

Antibodies to S. salivarius, S. sanguis, and S. mutans cells and to glucosyltransferases (GTF) prepared from these micro-organisms were measured in the sera of 133 infants and children by enzyme-linked immunosorbent assay (ELISA). IgG antibody activity to each cell type and GTP was present at birth (presumably derived from maternal transfer) and declined significantly thereafter. IgG antibody levels to S. salivarius and S. sanguis were next detected in young children (2 to less than 3 yr group). However, an increase in IgG antibody to S. mutans cells was not seen until children were older (4 to less than 8 yr group), possibly reflecting the later colonization of this organism. In contrast, IgG antibody to GTF of all three streptococcal species remained at low levels throughout the first four years of life. IgG antibody to S. mutans GTF was then the first to appear (4 to less than 8 yr group). Serum IgA antibodies to all GTFs were not detected until after this time. Fifteen sera were used to develop IgG immunoblots with the GTF antigens. Some positive sera (7/12) demonstrated reaction(s) with GTF from each of the three streptococcal species. Individual sera showed IgG antibody bonds to GTF from several serotypes of the mutans streptococci. No immunoblot reaction was observed with GTF and sera (3) from the four-to-seven-year and younger age groups. These results indicate the presence of serum antibody to bacteria and bacterial products associated with plaque formation very early in life and during and after the pre-adolescent years. The potential exists for this serum antibody to modulate bacterial colonization or accumulation in the oral cavity.

Adult↗
PubMedDate not supplied

The effect of outliers on confidence interval procedures for cost-effectiveness ratios.

Cost-effectiveness ratio (CER) is defined as the ratio of the difference in cost between a test and standard health care programme to the difference in benefit, respectively. Methods to obtain confidence intervals for CERs are either variants of Fieller's method (1954), or bootstrap methods. We study the effect of outliers in cost measures on the precision of confidence interval procedures for CERs. In particular the performance of the procedures under single and multiple case influential deletion diagnostics, respectively, are evaluated. Simulation studies suggest that the bias-corrected percentile bootstrap procedure gives better precision and coverage under either diagnostic.

Computer Simulation↗
PubMedDate not supplied

RASSE: a new method for structure-based drug design.

A novel method, RASSE, has been developed to suggest reasonable structures which can fit well to the binding sites of receptors. Molecules are generated by an iterative growing procedure in which atoms are added to existing fragments. Potential ligands are then picked out by special scoring rules. This atomgrowing based method is characterized by combinatorial searching of atom types and conformations. To some extent, it is the computer simulation of combinatorial chemistry. This method has been applied to the design of inhibitors for E. coli dihydrofolate reductase and human phospholipase A2. The results demonstrate that this program is capable of generating reasonable structures, thus proving its power in drug design.

Binding Sites↗
PubMedDate not supplied

Younger and older adults' recall of typical and atypical actions from script-based text: evidence for interruption and bizarre-imagery effects.

In the present research, younger (mean age 20) and older (mean age 78) adults' perception and recall of scripted and nonscripted actions were examined. Two primary types of nonscripted or atypical actions were presented: those that interrupted the sequence of the script and those that were irrelevant to the script. Script-irrelevant actions also varied in terms of how plausible they were in relationship to both the sentence they were embedded in and the context of the story. Across experiments, both younger and older adults recalled script-interruptive actions better than all other actions, including script actions. In addition, an unexpected finding was that both younger and older adults recalled implausible (bizarre) script-irrelevant actions better than script actions. This latter finding suggests that a bizarre-imagery effect may operate in both younger and older adults. Older adults' better recall of atypical actions over script actions is noteworthy, as these results question the assumption that older adults show an increased reliance on their schematic knowledge structures to recall. Contrary to expectations, older adults showed better recall of actions that required more active story integration (interruptive and implausible atypical actions) than actions requiring less integration (script and plausible atypical actions).

Adolescent↗