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Biomedical subjects

Z Laron

Publications and source records attributed to Z Laron.

At least 343 records · Page 19Linked to original sources
PubMed1975

The LH response to LH releasing hormone in children with true isosexual precocious puberty treated with cyproterone acetate.

Fourteen girls and one boy with isosexual precocious puberty were submitted to LHRH stimulation tests, during and without therapy with cyproterone acetate. In addition, fourteen girls with isosexual precocious puberty not receiving any therapy were tested and served as controls. It was found that cyproterone acetate induces suppression of the responsiveness of the pituitary gland to secrete LH on LHRH stimulation. Daily oral therapy was found to be more effective than the regimen of intramuscular depot injections. These findings demonstrate that cyproterone acetate has an antigonadotrophic effect.

Administration, Oral↗
PubMed1975

Plasma glucagon response to arginine infusion in children and adolescents with diabetes mellitus.

Plasma glucagon response to an arginine infusion was studied in children and adolescents belonging to the following groups: (I) twenty-two controls; (II) six subjects with delayed insulin peak during oral GTT; (III) ten diabetics on diet and/or oral therapy; (IV) six newly diagnosed uncompensated diabetics; and (V) eight diabetics on insulin therapy. The fasting glucagon concentrations and rise of glucagon in response to arginine in the patients of Groups II, III and V were similar to those of the controls (Group I). The basal levels and rise of glucagon in the newly diagnosed, uncompensated dibetic children (Group IV) was elevated compared to the other groups but the difference was statistically not significant. The results of this investigation favour the hypothesis that the hyperglucagonaemia in diabetes is a secondary effect to the metabolic derangement, bearing a direct relationship to the degree of homeostastic decompensation.

Adolescent↗
PubMed1975

Insulin response to intravenous glucagon in children with familial constitutional short stature.

An intravenous glucagon test was performed in 8 children with familial constitutional short stature who were also lean. These children were randomly selected from a larger group of children with the same clinical manifestation and who had been shown to have a low insulin response to an oral glucose tolerance test and to an intravenous arginine test, without glucose intolerance. 7 out of 8 children showed a normal insulin response to intravenous glucagon, with a peak level of 53--180 millimicron/ml 2 minutes after the injection. It is assumed that these insulin responses represent an intact 'rapid' pool of insulin within the beta-cell, and can explain the absence of glucose intolerance in all the children so far studied.

Blood Glucose↗
PubMed1975

Plasma LH and FSH response to LRH in boys with compensatory testicular hypertrophy.

The plasma LH, FSH and testosterone response to LRH was studied in 12 boys with compensatory testicular hypertrophy (CTH) and normal puberty and in a matched control group with normal testicular development. It was found, that the boys with CTH had normal basal plasma testosterone and LH concentrations; at the same time the basal plasma FSH level were significantly higher than in the control group. The response of plasma LH and FSH to LRH was markedly greater in the CTH group than it was in the control group. It is concluded, that the contralateral testicular hypertrophy which enables a normal pubertal process is the result of increased secretion of gonadotropins, mainly FSH.

Adolescent↗
PubMed1975

Prevention of hypoglycemic attacks by propranolol in a patient suffering from insulinoma.

An insulinoma was diagnosed in a fifty-seven-year-old woman suffering from frequent hypoglycemic attacks. Propranolol--a beta-adrenergic blocker--in a dose of 80 mg. per day effectively prevented recurrent hypoglycemic attacks. It also corrected the basal hyperinsulinemia as well as the increased insulin secretion which results from stimulation with glucose or arginine.

Adenoma, Islet Cell↗
PubMed1975

Adjustment and rehabilitation problems of children and adolescents with growth retardation. I. Familial dwarfism with high plasma immunoreactive human growth hormone.

Nine children and adolescents with the syndrome of familial dwarfism and high plasma immunoreactive human growth hormone were assessed by means of a battery of psychological tests, and they and their parents were interviewed with the aim of studying the problems of adjustment and rehabilitation in this group of patients. The group as a whole showed a lower-than-average intelligence quotient and a distinct deficiency in visuomotor functioning. Although this type of dwarf is well proportioned and without major malformations, his markedly small stature and limited physical endurance cause various problems, including those of mobility, clothing, and accommodation to public transportation and normal-sized furniture in school and at work. Psychological problems include intrafamily relationships and the attitudes encountered in school, in social situations and at places of employment. It is concluded that these patients need the specialized counseling of a centralized rehabilitation center which offers a combined program of medical care, psychological support and assistance with such problems as schooling, choice of occupation and the finding of suitable employment. It is suggested that the rehabilitation problems and needs of all dwarfs are similar, irrespective of the etiology of the dwarfism.

Activities of Daily Living↗