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Biomedical subjects

Z Kleinrok

Publications and source records attributed to Z Kleinrok.

At least 253 records · Page 14Linked to original sources
PubMed1976

Synthesis of 3-aryl-2-thiohydantoin- and 3-arylhydantoin-5-acetic acids and screening of some of their pharmacological properties.

Seven 3-aryl-2-thiohydantoin-5-acetic acids were obtained from asparagine and arylisothiocyanates. After desulphuration of these compounds by monochloroacetic acid seven 3-arylhydantoin-5-acetic acids were obtained. The structure of these compounds was confirmed by their IR spectra. None of the compounds neither showed the anticonvulsive activity in the electroconvulsions and pentylenetetrazole tests nor inhibited the prostaglandin synthetase.

Animals↗
PubMed1975

Central action of drugs acting on the cholinergic muscarinic receptor. IV. Influence of cholinomimetics and cholinolytics injected into the lateral cerebral ventricle in the rat on concentrations of 5-HT and 5-HIAA.

The influence of cholinomimetics (carbachol--CCh, physostigmine--Pht, pilocarpine--Pil) and cholinolytics (atropine--At, scopolamine--Sc) injected into the lateral ventricle of the brain (ivtr) in rats on metabolism of 5-HT was studied by assaying levels of 5-HT and 5-HIAA. In several comparative experiments cholinomimetics were injected i.p. CCh had no influence on levels of 5-HT and 5-HIAA when injected i.p., but raised levels of 5-HIAA injected ivtr. Pht had no influence on concentrations of both substances by either route of administration. Pil raised levels of 5-HIAA when injected i.p. (and by this route of administration also raised levels of 5-HT) as well as ivtr, Both cholinolytics injected ivtr had no influence on concentrations of 5-HT or 5-HIAA.

Animals↗
PubMed1975

Central action of drugs acting on the cholinergic muscarinic receptor I. Influence of cholinomimetic drugs administered into the lateral cerebral ventricle on behavior in rats.

Carbachol (CCh), physostigmine (Pht) and pilocarpine (Pil) injected into the lateral cerebral ventricle (ivtr), diminished spontaneous motility and open-field performance, lowered body temperature, depressed amphetamine-induced hypermotility, and inhibited amphetamine stereotypy. On the other hand, they had no effect on duration of hexobarbital anesthesia, except Pil, which slightly prolonged it, or on the action of threshold dose of pentetrazole and maximal electroshock. The compounds raised levels of "free" and "total" ACh, but not those of "bound" ACh. Level of NA in the brain was decreased, while level of DA was unaltered. These results are further evidence of an inhibitory influence of cholinomimetic drugs on behavior in animals.

Acetylcholine↗
PubMed1975

Central action of drugs acting on the cholinergic muscarinic receptor. II. Influence of ecothiopate administered into the lateral cerebral ventricle on behavior in rats.

Ecothiopate (Etp), 10 mug injected into the lateral cerebral ventricle (ivtr), diminished spontaneous motility and open-field performance, lowered body temperature, inhibited amphetamine-induced hypermotility and stereotypy, prolonged hexobarbital anesthesia and did not induce catalepsy. These behavioral symptoms were accompanied by lowered level of NA and elevated levels of 5-HT and 5-HIAA in the brain. No change in levels of DA were noted. Smaller doses (0-1 and 1 mug) had virtually no influence on behavior of the animals. The dose of 1 mug caused a rise in levels of 5-HIAA in the brain, but had no influence on levels of NA, DA and 5-HT.

Amphetamine↗
PubMed1975

Central action of drugs acting on the cholinergic muscarinic receptor. III. Influence of atropine and scopolamine injected intraventricularly on behavior and levels of biogenic amines in the rat brain.

Atropine (At) and scopolamine (Sc) in low doses intensify basic activity, increase amphetamine stereotypy, and suppress catalepsy induced by injection of haloperidol. High doses lower body temperature, antagonize amphetamine stereotypy, and intensify the hypnotic action of chloral hydrate. Doses of about 1/2 LD50 induce narcotic sleep. Both At and Sc in a wide range of dosage protect against the tonic phase of convulsions produced by electroshock. Sc depresses content of acetylcholine in the brain proportionally to its dosage; At had a similar effect only at the lower of the two doses that were used. Both compounds had no effect on levels of noradrenaline and dopamine in the brain. The results indicate that low doses of blockers of the cholinergic muscarinic receptor, injected intraventricularly, produce strong central stimulation, whereas high doses produce depression of the central nervous system.

Acetylcholine↗
PubMed1975

The influence of alkaline elements on the metabolism of 5-hydroxytryptamine in rat's brain.

A single or four time-administration of Li, Na, K, Rb and Cs chlorides at the doses of 2-5 and 5 mEq/kg ip does not significantly affect 5-HT level. The level of 5-hydroxyindoleacetic acid (5-HIAA) increase only after the administration of LiCl. This increase occurs already after 1 hr and persists up to 24 hrs after the last injection. LiCl given together with probenecid induces the increase in 5-HIAA level greater than that after probenecid alone. The decrease in 5-HIAA level after pargyline-induced inhibition in MAO is more rapid in animals submitted to two action of Li. The increase 5-HIAA level in rat's brain results from Li ions-increased 5-HT turnover.

Animals↗
PubMed1975

Influence of fluorostigmine on some parameters of the catecholaminergic and serotoninergic systems in the mouse brain.

Fluorostigmine (DFP) injected i.p. in doses of 2-45 and 5-0 mg/kg in mice distinctly lowered levels of noradrenaline in the brain, raised levels of dopamine slightly, and very distinctly raised levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. The same dose also weakened MAO activity and diminished oxygen uptake by brain tissue. Drugs which antagonized the above-mentioned changes in the levels of biogenic amine (L-DOPA, PCPA, reserpine) or blocked receptors (phentolamine) only slightly diminished acute toxicity of DFP. On the other hand, a-methyl-p-tyrosine, d,l-tryptophane and nialamide had virtually no effect on acute toxicity.

Animals↗
PubMed1975

The influence of phentolamine on the central activity of 5-hydroxytryptamine in rat.

PHENT (20 and 100 mug ivc) affects the central action of 5-HT (0-1, 25 and 250 mug) in rats which shows itself in potentiation of 5-HT-induced inhibition of spontaneous locomotor and exploratory activities and in the prolongation of hexobarbital sleeping time. In case of postamphetamine hyperactivity and body temperature, 5-HT acts antagonistically to a lower PHENT dose and synergistically to a higher dose of this compound. No affect of 5-HT on a slight antistereotypy action of PHENT has been stated. Neither compound affects electrical seizures.

Animals↗