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Biomedical subjects

Z Kirkali

Publications and source records attributed to Z Kirkali.

At least 91 records · Page 5Linked to original sources
PubMed1990

Androgen receptors--a method to measure functional behaviour in human prostatic cancer.

Androgen receptors were measured in soluble and nuclear fractions of tissues obtained from 25 patients. A method using mibolerone, a synthetic androgen, as a ligand is described. This method, which includes the presence of excess ORG 2058 to eliminate interaction with progesterone receptors, gives a reliable determination of androgen receptor content and has been used to predict response to hormonal treatment. However, the results suggest that the presence of functional receptor is not, in itself, a sufficient index of hormonal dependence of the tumour.

Aged↗
PubMed1989

Urothelial tumours of the upper urinary tract.

We present a retrospective 10 year analysis of 76 patients with urothelial tumours of the upper urinary tract. Patients older than 65 years, and female patients, presented with more advanced stages and had a worse prognosis. The grade and stage of the tumour has the greatest impact on survival. No conclusions can be drawn on the efficacy of various types of surgery, but simple nephrectomy gave a 5-year survival of 68%, with a stump recurrence rate of 15%. We observed that patients with urothelial tumours had 4 fold increased chance of developing gastrointestinal cancer.

Actuarial Analysis↗
PubMed1988

Bladder agenesis.

Agenesis of the bladder is an extremely rare anomaly with only approximately 40 such cases reported in the literature. We report on a 30-year-old female patient who also had right renal agenesis.

Abnormalities, Multiple↗
PubMed1988

Ureterorenoscopy: a new approach in the diagnosis and treatment of upper urinary tract disorders.

Endoscopy is a well-established method of diagnosing and treating lower urinary tract disorders. Developments in the optical quality and manufacture of more precise instruments now also makes inspection of the upper urinary tract possible. Today, ureteric stones can easily be dealt with by non-operative measures with the use of operating ureterorenoscope. Diagnosis and treatment of other pathological conditions of the upper urinary tract are also possible. It is also the best way of assessing ureteric and renal pelvic tumours.

Endoscopy↗
PubMed1988

Amiodarone-induced sterile epididymitis.

Sterile epididymitis in 2 patients who were on amiodarone for cardiac arrhythmias is presented. Decrease in drug dosage rendered the patients pain-free and testicular swelling resolved in a fortnight.

Amiodarone↗
PubMed1988

Blood groups and transitional cell carcinoma of the upper urinary tract.

A retrospective analysis of the blood groups of 74 patients with transitional cell carcinoma of the upper urinary tract is presented. The blood group distribution of the patients reflected that of the general population. No relationship was found between blood groups and stage and grade of the tumour or patient survival. Nor were blood groups predictive of bladder tumour recurrence and stump recurrence in patients who had undergone simple nephrectomy.

Adult↗
PubMed1988

Spontaneous kidney rupture in polyarteritis nodosa. Report of four cases.

Spontaneous kidney rupture as the initial manifestation of polyarteritis nodosa is rare. We present 4 such patients who underwent nephrectomy. We suggest primary nephrectomy in patients with spontaneous kidney rupture and resultant retroperitoneal hematoma in whom no preoperative diagnosis is available.

Adolescent↗
PubMed1987

The use of oxybutynin in urological practice.

A total of 216 patients with voiding disorders were treated with oxybutynin and the effects and side effects were studied. The drug is effective in a wide variety of disorders. Good results were obtained in 66% of patients who had no previous treatment and in 46% of patients who had taken various drugs before. It was just as effective in all age groups. Twenty-three per cent of patients experienced side effects and 10% were unable to tolerate the drug. It is concluded that oxybutynin is an effective drug in the treatment of unstable bladder and disorders such as catheter-induced spasms.

Adolescent↗
PubMed1987

Unusual metastases of renal cell carcinoma.

The case of a 55-year-old white male with recurrent metastases in the oral cavity and maxillary sinuses, as well as other organs, is presented. Local excision of the lesions, hormonal treatment and palliative measures for other metastases were used. The patient is alive 10 years after the initial diagnosis.

Carcinoma, Renal Cell↗
PubMed1986

The role of delay in stage III testicular tumours.

Twenty-nine patients with stage III testicular tumours seen between 1979 and 1984 were analysed for the relation between delay in both diagnosis and chemotherapy, and prognosis. The complete response (CR) rate was 40% for patients who were treated within 6 months from onset of symptoms, and 26.3% for patients who had an interval longer than 6 months. We believe that delay in diagnosis and chemotherapy may affect the response to treatment. Health education of the male population for self-examination of the testes is an important factor to minimize this delay.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

The effect of ergobromocriptine on serum testosterone and prolactin levels in patients with carcinoma of the prostate.

The effect of Ergobromocriptine treatment on serum testosterone and prolactin levels in 15 patients with prostatic carcinoma and 15 patients with benign prostatic hyperplasia was examined. The prolactin levels which were elevated in patients with prostatic carcinoma showed a significant decrease after suppression with Ergobromocriptine. The selective effect of Ergobromocriptine on prolactin levels of patients with prostatic carcinoma may control the progression of the disease.

Adult↗
PubMed1986

The role of delay in stage-III testicular tumors.

Twenty-eight patients with stage-III testicular tumors seen between 1979 and 1984 were analyzed for the effect of delay on diagnosis and chemotherapy and prognosis. A statistically significant relation was determined between the symptom-diagnosis interval and extent of the disease. The complete response (CR) rate was 67% for patients treated within 6 months of symptoms, on the contrary only 16% of patients with interval longer than 6 months to treatment had CR (p less than 0.05). We believe that delay in diagnosis and chemotherapy may affect the response to treatment. Health education of the male population for self-examination of the testes is an important factor for minimizing this delay.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1985

Haemoglobin F levels in patients with testicular tumours.

This study was designed to examine haemoglobin F levels prior to therapy in 39 patients with testicular tumours (10 seminoma, 29 non-seminomatous tumours) and 20 controls. HbF levels were significantly increased in the group with testicular tumours (1.66 +/- 0.12%) compared with normal controls (0.99 +/- 0.08%) (P less than 0.001). Non-seminomatous tumours had more pronounced levels than seminomas (P less than 0.001). No correlation was found between HbF level and stage of the disease. We suggest that HbF production could be significantly reactivated in adult patients with testicular tumours and may be a useful marker.

Adult↗