Search PubMed⌕ Search

Biomedical subjects

Z Kazibutowska

Publications and source records attributed to Z Kazibutowska.

34 records · Page 2Linked to original sources
PubMedDate not supplied

[Value of the studies of multimodal evoked potentials for evaluation of neurotoxic effects of combined exposure to lead, copper and zinc].

Central nervous system dysfunction was studied in workers with occupational exposure to Pb+Cu+Zn by measuring somatosensory evoked potentials of short and long latency, visual evoked potentials and brain-stem evoked auditory potentials. The tests were done in 40 workers with a history of exposure from 6 to 19 (mean 14.3) years in a copper foundry. Pb poisoning was not diagnosed in them, but 18 workers had some abnormalities of heme synthesis. Pb concentration in blood was from 11.4 to 62.8 (mean 35.7) mcg% in the whole group. Pb concentration in air in the foundry exceeded 1.1-175 times the MAC value, the concentration of CU exceeded it 7.25 times. Zn concentration was half the MAC value. No significant abnormalities were found in the parameters of multimodal evoked potentials. The obtained data suggest a protective effect of copper and zinc on heme , Pb blood level and conduction velocity of somatosensory, visual and auditory impulses in workers exposed to high Pb air concentration.

Air Pollutants, Occupational↗
PubMedDate not supplied

[Value of multimodal evoked potentials in the assessment of the neurotoxic effects of carbon disulphide].

Central nervous system dysfunction among CS2-exposed workers was studied by measuring short latency SSEPs and VEPs. The examinations were done in 40 men. Chronic CS2 intoxication was diagnosed in 21 of them. Latency of N19, N11, N20 of somatosensory evoked potentials and latency of P100 wave of visual evoked potentials were statistically significant longer in CS2 exposed group in comparison with controls. The amplitude of N20 SSEPs was also significantly higher. Increase of N20 amplitude (33 persons) and elongation of its latency (25 persons) were frequent abnormalities of SSEps. In individual assessment of VEPs, most frequent were: abnormal difference in interocular latency of P100 (26 persons) and elongation of P100 latency (25 persons). In the analysed SSEPs and VEPs parameters there was no significant difference between two clinical groups. The authors conclude that the CS2--neurotoxic effect leads to impairment of the peripheral and central part of the somatosensory pathway, as well as to central dysfunction of the visual pathway.

Adult↗
PubMedDate not supplied

[Treatment of Guillain-Barré syndrome by the method of fractionated plasma exchange with controlled hemodilution].

Plasma exchange under controlled haemodilution was tried in 9 patients with Guillain-Barré syndrome repeating the procedure at 24-hour intervals for from 7 to 17 times with a total exchange of plasma ranging from 2.0 to 4.9 litres. All patients had significant paresis or paralysis of all four extremities, and 3 had additionally respiratory failure. The criteria accepted for performing plasmapheresis included a very severe form of the disease and a steady progression of signs despite treatment with corticosteroids. Already after the first exchange of plasma arrest of disease progression was observed in all cases, and after the 2nd or 3rd exchange a progressing improvement began. Six patients regained the ability of walking within 4 to 8 weeks, all were discharged walking unaided. The obtained results suggest the conclusion that the therapeutic method used is a very effective way of treating severe cases of Guillain-Barré syndrome and should be used in these patients.

Adult↗
PubMedDate not supplied

[Visual evoked potentials and the time of motor reaction to visual stimuli in chronic metallic mercury poisoning].

In a group of 10 patients with diagnosed occupational chronic poisoning with metallic mercury a correlation was sought between the parameters of the visual evoked potentials and the results of the psychological test evaluating the rapidity of motor response to the visual stimuli. The analysis suggest a cerebral dysfunction of the visual neurons and reduced rate of visual information transformation to the motor effector at the level of the cortical association centre.

Adult↗
PubMedDate not supplied

[Porphyria variegata--a case report].

In a man aged 28 years abdominal pains with constipation appeared, and were followed after 2 weeks by generalized maximal epileptic seizures, gradually progressing signs of proximal polyneuropathy, numerous brownish patches on the face and trunk, and hepatomegaly. In the urine raised levels were found of delta aminolaevulinic acid, prophobilinogen, coproporphyrins and uroporphyrins. Examination of stools demonstrated an increase of protoporphyrins and coproporphyrins, with prevalence of the former, characteristic of porphyria variegata. A gradual regression of changes was observed after treatment with high doses of propranolol and intravenous glucose infusions.

Abdomen↗
PubMedDate not supplied

[Biochemical and electrophysiological studies in subjects with occupational exposure to lead poisoning].

In 36 men working in occupations with lead exposure the conduction velocity was measured in the motor fibres of the median, ulnar and peroneal nerves, and determinations were carried out of blood lead level, 24-hour urinary excretion of lead and delta-aminolaevulinic acid, and activity of delta-aminolaevulinic acid dehydratase in the erythrocytes. The comparison of the results of electrophysiological and biochemical investigations shows that lesions of the peripheral nervous system are not always correlated with the biochemical indices of lead poisoning and that peripheral nervous system damage, mainly subclinical, may develop in early period of exposure.

Adult↗
PubMedDate not supplied

[EEG in offspring of epileptic mothers].

In a group of 134 children of epileptic mothers abnormal EEG tracings were found in 39.6% of cases, 7 of these children (5.2%) had epileptic seizures. In 92% of cases EEG changes had the character of paroxysmal dysrythmia, and they were significantly more frequent in children aged 5 to 14 years and significantly more frequent in the children of mothers who had had epilepsy before the age of 20 years. Pathological EEG changes were more frequent in daughters than in sons, and in the daughters generalized discharges of centrencephalic type were significantly more frequent. In all families with more than two children at least one child had pathological EEG tracings.

Adolescent↗
PubMedDate not supplied

[Lioresal in the treatment of hemiplegia. Clinical and electromyographic evaluation. Preliminary report].

On the basis of an analysis of the clinical condition and electromyographic changes in 9 patients treated with Lioresal and 3 controls attention is called to the favourable effect of Lioresal in hemiparesis of cerebral origin. Lioresal was given in daily doses of 50 mg and no unfavourable side effects were observed. Reduction of muscular hypertonia and improvement of general motor activity was obtained.

Adult↗
PubMedDate not supplied

[Case of Henoch-Schoenlein purpura with neurological complications].

In a 11-year-old girl with urinary tract infection symptoms and signs of Henoch-Schoenlein syndrome developed with neurological complications in the form of headaches, vomiting slightly marked signs of pyramidal tract and cerebellar damage and severe psychomotor temporal-lobe seizures. These very violent neurological manifestations disappeared completely after control of infection. The authors point out that prognosis in Henoch-Schoenlein syndrome even with such severe neurological complications is good.

Child↗
PubMedDate not supplied

[Mental development of the children of epileptic mothers].

In a group of 152 children of epileptic mothers mental deterioration was recognized in 8,5% of cases, that is four times more frequently than in the general population. Children showing evidence of mental retardation were more frequently products of pregnancy during which their mothers had epileptic seizures and were taking drugs. An evident correlation between the intelligence level of the mothers and their children and the efficiency of different psychic functions in both groups suggest a possible role of a genetic factor.

Adolescent↗
PubMedDate not supplied

[Case of a particularly severe migraine in a boy].

An unusually severe and uncommon clinical syndrome of migraine with complications in a boy treated during 9 years is described. Severe attacks of migraine were associated with changing cerebral function defects, prolonged disturbances of consciousness, and significant symptoms of intracranial hypertension. Vertebral angiography demonstrated disturbances in cerebral circulation.

Age Factors↗
PubMedDate not supplied

[Effect of infections on the course and effectiveness of epilepsy treatment in children].

The analysis was carried out in a group of 32 children with coexistent chronic urinary tract or respiratory infections. In 20 children an unfavourable effect of infection on the course of epilepsy was observed. Worsening of epilepsy during infection was observed mainly in children without evidence of nervous system damage with primarily generalized seizures, and in cases when the first attacks developed after protective vaccinations. The effect of urinary tract infections was particularly unfavourable. The authors put forward the hypothesis of immunological basis of exacerbation of epileptic seizures during chronic infections.

Adolescent↗
PubMedDate not supplied

[Transcranial Doppler ultrasonography and hyperventilation test in assessment of cerebral vasoreactivity after ischemic stroke].

In 36 patients 3 month after ischaemic stroke in regions supplied by MCA (Middle Cerebral Artery) physical examination, CT scanning and blood flow velocity recordings in ICA (Internal Carotid Artery) and MCA were performed. In both MCA blood flow velocity was measured in resting state and after 30 sec. of hyperventillation. The control group consisted of 40 healthy volunteers. In the control group blood flow decrease after hyperventillation was nearly equal in both hemispheres (38% in right and 37% in the left hemisphere). In studied group in the symptomatic hemisphere blood flow reduction was 21%. Vasoreactivity in the opposite hemisphere was similar to that in control group (35% decrease). The results suggest that vasoreactivity diminution is a local phenomenon limited to the infarcted area. Hyperventilation test, despite its simplicity, seems to be sufficient for screening vasoreativity.

Adult↗