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Biomedical subjects

Z Kaufman

Publications and source records attributed to Z Kaufman.

At least 55 records · Page 3Linked to original sources
PubMed1985

Desmoid tumor--review and follow-up of ten cases.

Ten cases of desmoid tumor, diagnosed, treated, and followed during the past 11 years, were reviewed and the patients reexamined. Two were up to 3 years, two up to 5 years, and four up to 11 years after excision. The remaining two patients were lost to follow-up. The 10 patients included one male and nine females; six females were of childbearing age and three were postmenopausal. In four females the desmoid tumor was located near various surgical scars. In the one recurrent desmoid it was most probably related to both repeated traumatization of the abdominal wall due to pregnancies and hyperestrogenism. All the surgical margins of resection were microscopically involved by the process. An open liver biopsy, performed simultaneously with the excision of the recurrent desmoid, showed benign nodular hyperplasia compatible with hyperestrogenism. Estrogen and progesterone receptors of this desmoid were negative. In the present series follow-up revealed, in contrast to general agreement, that in spite of incomplete excision, the recurrence rate was low. We suggest that the surgical approach to desmoid tumors could be less radical, except possibly for lesions in patients with multiple causative factors.

Abdominal Neoplasms↗
PubMed1985

Bilateral primary malignant lymphoma of the breast.

A rare case of bilateral primary malignant lymphoma of breast in a 76 year old woman is presented. The lesion was examined by electron microscopy and immunochemistry. The diagnosis of primary malignant lymphoma remains a diagnosis by exclusion and requires extensive work-up to exclude widespread malignant process. The behaviour of this malignancy tends to be an aggressive one and the prognosis is generally poor.

Aged↗
PubMed1984

Systemic prophylactic antibiotics in elective biliary surgery.

We tested the effectiveness of prophylactic antibiotics in elective cholecystectomy in 105 patients in a single-blind, controlled randomized trial. Fifty-six patients received prophylactic antibiotics and 49 patients entered the control group. Of the patients who received prophylactic antibiotics, 3.6% had wound infections, v24.5% in the control group. The rate of wound infection in patients with positive bile cultures, diabetes, appendectomies, and choledochotomies was 24.4%, v 3.4% in the group who had cholecystectomies only, with negative bile cultures and no diabetes. We concluded that prophylactic antibiotics are effective in patients with high-risk factors such as diabetes mellitus, exploration of the choledochus, and appendectomy, and in patients with positive bile cultures.

Adult↗
PubMed1984

Primary gastrointestinal lymphoma: a review of 21 cases.

A retrospective study of 21 patients who had suffered from gastrointestinal lymphoma was carried out. Gastric involvement was more common than involvement of the small or large intestine and carried a better prognosis. Gastrointestinal lymphoma generally occurs most frequently during the fourth to seventh decades of life. In our study, however, five lymphomas occurred in patients under 20 years of age. Clinical symptoms were nonspecific, and abdominal mass was found in only 15% of the patients on clinical examination. All patients were explored, 17 underwent resection, and 4 laparotomy and biopsy. Five-year survival was much better for patients who had undergone resection. Survival was inversely proportionate to the extent of nodal spread. Multiple lesions on the same organ yielded a 5-year survival of 20%, while a single lesion offered a 55% chance of 5-year survival. Diffuse histiocytic lymphoma was the commonest type, followed by the poorly differentiated lymphocytic type. A longer survival rate was present in the lymphocytic type. However, the highest survival rate was in those patients in whom definite resections of the lesion were performed followed by radiation and chemotherapy, especially for gastric tumor.

Adolescent↗
PubMed1984

Reinsertion of a catheter for feeding jejunostomy.

A simple technique for the reinsertion of a feeding jejunostomy after its breakdown is described. The catheter of the old jejunostomy was used as a guide for the new one. This technique allows the old catheter to be changed by nonoperative means, thus avoiding a second laparotomy. No complications occurred following this procedure.

Catheterization↗
PubMed1981

Fecal fistula: a late complication of Marlex mesh repair.

Marlex mesh is an excellent prosthetic material for closure of major abdominal defects. Most of its complications are seroma and infections. We have used Marlex mesh intraperitoneally for closure of burst abdomen in a patient who had a gastrectomy for recurrent duodenal ulcer. A year and a half later, this patient developed a fecal fistula to the skin due to incorporation of the Marlex mesh into the splenic flexure of the COLON. The patient underwent a second operation during which the fistula was resected and the Marlex removed. We concluded that intraperitoneal placement of Marlex mesh is not recommended.

Adult↗
PubMedDate not supplied

Oncoprotein coexpression in human aberrant crypt foci and minute polypoid lesions of the large bowel.

BACKGROUND: Genetic aberrations observed in the large bowel during the neoplastic progression have a cumulative effect and are responsible for the propagation of the multistep malignant process. In the present study we evaluated the immunoreactivity of c-fos, ras, bcl-2 and p53 in aberrant crypt foci (ACF) and minute polyps of the large bowel obtained from patients with colorectal cancer. METHODS: ACF and minute polyps were collected from macroscopically normal colonic mucosa. Protein immunoreactivity was detected on parafin sections utilizing the biotin-streptavidin method on 25 hyperplastic, 10 dysplastic ACF, 5 hyperplastic and 10 dysplastic adenomas. RESULTS: 41% of the lesions displayed positive ras immunoreactivity. bcl-2 immunoreactivity was positive in six minute polyps of which five were neoplastic. fos immunoreactivity was detected in five ACF and seven minute polyps, mainly in dysplastic lesions. Two neoplastic polyps were positive for p53 immunoreactivity. Coexpression of two or more oncoproteins was found with increasing frequency in dysplastic versus hyperplastic lesions and in polypoid lesions versus ACF. CONCLUSION: Abnormal expression and coexpression in oncoproteins can be identified in the earliest stages of colorectal tumorigenesis and may contribute to the progression of selected lesions during ACF-adenoma-carcinoma sequence.

Colon↗