[Indications for testicular biopsy].
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Biomedical subjects
Publications and source records attributed to Z Janczewski.
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The authors present the histological features of the testes in 1,609 cases of male sterility. In 485 cases (30.1%), histological changes were found, which did not warrant treatment. The histologic pattern of the testes was normal in only 39% of the cases of azoospermia; and only these patients were qualified for surgery, consisting of vasoepididymoanastomosis. Degenerative changes in the seminiferous tubules were observed in the patients with azoospermia, oligozoospermia and varicocele in 39.9%, 25.8% and 17.2% of cases, respectively.
The plasma FSH and testosterone levels were determined by the radioimmunological method in 27 men with azoospermia. The plasma FSH levels were elevated in the Sertoli-cell only syndrome and in the case of inhibited spermatogenesis. The plasma FSH level was normal in patients with normal spermatogenesis. The plasma testosterone level did not differ from the normal values in any of the above-mentioned groups of patients.
The testosterone, FSH and LH plasma levels were determined simultaneously in spermatic and cubital veins in 15 patients with post-inflammatory azoospermia. The testosterone levels in spermatic vein was 13,1 +/- 2,9 times higher than in cubital vein. FSH spermatic plasma level was slightly higher than in cubital vein, whereas LH spermatic plasma level did not differ from that found in the cubital vein.
The plasma level of testosterone, FSH and LH were determined simultaneously in spermatic and cubital veins in 12 patients with varicocele. The testosterone levels in spermatic veins were 13.4 +/- 5.3 times higher than in cubital veins. FSH and LH levels were higher in cubital than in spermatic vein. No correlation was found between the number of spermatozoa in 1 ml of semen, and the level of the three hormones studied, either in the cubital or in spermatic vein.
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A structure of the convoluted tubuli, spermatogenesis and number of Leydig's cells in the andropause have been analysed in dependence on the degree of symptoms intensity. A control group included otherwise healthy men with ++post-inflammatory azoospermia. A percentage of the convoluted tubuli with normal tissue (p < .002) and spermatogenesis (p < .001) has been significantly decreased in andropause. The number of Leydig's cells has not differed in andropause and in a control group (p < .05). No difference of significance have been noted in the structure of convoluted tubuli, spermatogenesis, and Leydig's cells number depending on the intensity of symptoms. FSH and LH levels have been significantly increased in andropause (p < .001). No relationship between FSH and LH levels and percentage of the abnormal convoluted tubuli has been observed. However there have been a relationship between FSH and LH levels and the number of abnormal convoluted tubuli with spermatogenesis inhibition and intensified clinical symptoms. There has also been a relationship between FSH and LH levels and Leydig's cells number in patients with marked symptoms of andropause.
Changes in the biological value of sperm depending on the time of the first ejaculation are presented. A control group included 194 boys with normal puberty in whom a biologic value of sperm was evaluated in dependence of the first ejaculation. In all time points a biological value of sperm was significantly worse in the delayed puberty than that in the control group. Twenty four months following the first ejaculation sperm was not normal in any case whereas in the control group normospermia prevailed in this period of time.
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A group of 43 male patients aged between 50 and 67 years with the symptoms of andropause in presented. The patients were divided into three groups depending on the degree of the symptoms. Such a classification may facilitate a choice of therapeutical methods.
Blood plasma testosterone (T), estradiol (E2) levels and gonadal reserve in 43 patients aged between 50 and 66 years with andropause symptoms have been determined. The patients were divided into 3 subgroups depending on the severity of the symptoms. No significant difference was noted in T level of these patients compared to the range in younger males as well as a control group of corresponding age but with no andropausal symptoms. E2 level was significantly elevated in the observed group compared to the two control groups. No difference was noted in T and E2 levels between the 3 subgroups of the andropausal patients. Gonadal reserve in the observed group was significantly lower compared to the control groups of the younger males. No significant difference was noted in the gonadal reserve between 3 subgroups of the andropausal patients.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
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