[EEG investigations in obese children].
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Biomedical subjects
Publications and source records attributed to Z Huber.
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Bioelectric activity of the brain was investigated after Di-Te vaccination in healthy children. Seventeen healthy, randomly selected children aged 6-7 and 14 years were studied. EEG investigations showed appearance of significant changes in 13 out of 17 children. The main finding was appearance of previously absent or intensification of previously present seizure activity. Serial recording obtained in 10 children showed return of the initial state after about 3 weeks.
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On the basis of an analysis of a paediatric material the author discusses the most important elements influencing the pattern of developmental age epilepsy calling attention to the significance of early aetiological diagnosis since in this early period of life many processes can be treated causatively before epilepsy develops into a chronic disease. The dynamic course of epilepsy and classification difficulties resulting from clinical and electroencephalographic variability of childhood epilepsy are discussed explaining these facts by differences in structural maturity and functional organization at the age of development. It is indispensable to know the classification of seizure circuits for selection of possibly effective symptomatic treatment for prevention of seizures and their sequelae in the neuropsychiatric and social aspects. In the clinical course of a given case there are also individual differences between the seizure-releasing factors and their knowledge helps to avoid the critical threshold of seizure readiness releasing seizures in a given child. Acceptance of certain rules for observation in the everyday life of patients permits an individual prophylaxis of seizures. This shows that prevention of epileptic seizures includes not only causative and symptomatic treatment but also the knowledge of individual seizure-releasing factors which cannot be controlled pharmacologically.
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In 11 epileptics treated with DPH for 10-20 years a significant fall was observed in the serum levels of calcium, phosphates, and ionic index, with a significant rise in the serum magnesium concentration. No detectable changes were observed in the radiological appearance of bones and alkaline phosphates activity was within normal range. In two cases histological examinations demonstrated signs of osteomalacia. The authors postulate the necessity of monitoring selected parameters of calcium metabolism in patients on long-term treatment with diphenylhydantoin.
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