Biomedical subjects

Z Hou

Publications and source records attributed to Z Hou.

59 records · Page 4Linked to original sources

PubMed1991

Cytoreduction and sequential resection: a hope for unresectable primary liver cancer.

For decades, unresectable primary liver cancer (PLC) determined by operation was incurable. However, a retrospective study of 24 years' materials with unresectable PLC indicated that 5-year survival of unresectable PLC has increased from 0% in 1966-1977 (n = 137) to 16.9% in 1978-1989 (n = 345). This encouraging improvement was mainly a result of cytoreduction therapy followed by sequential resection. Multimodality combination treatment with hepatic artery ligation, plus hepatic artery infusion with chemotherapy, plus radioimmunotherapy (or radiotherapy) yielded the highest sequential resection rate (30.6%) and 5-year survival (28.0%) as compared with double combination and single modality treatment. The 5-year survival of 33 patients receiving sequential resection after cytoreduction therapy was 63.2%. It is suggested that cytoreduction and sequential resection might offer a hope for surgically verified unresectable PLC.

Adolescent↗

PubMed1991

Current management of hepatocellular carcinoma.

After a long, hopeless period in the management of hepatocellular carcinoma (HCC), the diagnosis and treatment of HCC have progressed remarkably in the past decade. In particular the discovery of asymptomatic HCC in the early 1970s opened up a new era in clinical research of HCC. With the progress in the diagnostic imaging of liver tumors, a 1 cm hepatic mass can now be detected. It is especially worth noting that a 5-year survival rate of 72.9% has been achieved after the resection of the tumor in asymptomatic HCC patients. The role of surgery in the treatment of HCC has become more important. Various modalities of medical treatment and combination therapy have been recommended and used. Despite the progress in the early diagnosis and treatment of HCC, a complete cure is very rare. Problems to be studied include new tumor markers for the early detection of alpha-fetoprotein (AFP)-negative HCC, the development of more specific treatments for unresectable HCC with uncompensated cirrhosis, and an effective approach to preventing recurrence and metastasis after radical resection.

Carcinoma, Hepatocellular↗

PubMed1990

[The anti-hemorrhagic shock of acupuncture on neiguan and its effect on the cardial pump function and the blood viscosity].

The purpose of this paper is to study and analyse the effects of the cardial pump function and the blood viscosity on rabbits with hemorrhagic shock by puncturing Neiguan. In the experiment 30 rabbits were divided into the electroacupuncture (EA) group and the control group, each group was 15 rabbits. The cardial pump function, the blood pressure and the blood viscosity were recorded during normalize, shock, and EA. The results were as following. 1. The blood pressure of the rabbits which were in hemorrhagic shock was raised by needling Neiguan. MAP was raised from 43 +/- 8 to 87 +/- 15 mmHg (p less than 0.001). 2. The cardial pump function were reinforced by needling Neiguan. SV was increased from 0.41 +/- 0.46 (before EA) to 0.73 +/- 0.12 ml (p less than 0.0001). CO, SI, CI. and WL were improved in a certain degree with difference significant. In the EA group the each index of the cardial pump function was higher than that of the control group. There was statistical significant between the two groups. 3. Needling Neiguan, the blood viscosity was tending to normality. The blood plasma viscosity was increased. There was significant difference (p less than 0.05). These results suggest that needling Neiguan may protect the cardial pump function, raise the blood pressure, play a positive role during anti hemorrhagic shock.

Acupuncture Points↗

PubMedDate not supplied

p53 and apoptosis alterations in keloids and keloid fibroblasts.

Keloids are the result of a dysregulated wound-healing process and are characterized by formation of excess scar tissue that proliferates beyond the boundaries of the inciting wound. In this study, we investigated the expression of key proteins involved in regulating apoptosis in keloids. Twenty archival paraffin-embedded keloid samples were randomly selected for an immunoperoxidase assay with antibodies against fas, p53, bcl-2, and bcl-x proteins using the target antigen-retrieval technique. Apoptosis was assessed in keloids and normal skin and in keloid and normal fibroblasts by the TdT-mediated dUTP nick-end labeling (tunel) assay on tissue sections, fibroblast cultures, and by flow cytometry for cell suspensions. We found that 18 of 20 keloids expressed p53 protein; bcl-2 was expressed by keloid fibroblasts in 19 of 20 keloids, and all specimens had prominent fas expression throughout the tissue. The distribution of these three antigens was regional within each lesion and followed a consistent pattern of p53 and bcl-2 expression colocalized to the hypercellular, peripheral areas of each keloid in a perinuclear pattern (p < .001). In contrast, an inverse distribution of fas expression was shown, with staining being more diffuse across the cell surfaces and limited to the central, more hypocellular regions in16 of 17 keloids (p < .001). There was no specific staining pattern in these keloids with antihuman bcl-x. In vitro studies on cultured keloid fibroblasts (derived from six patients) revealed maintenance of the p53+, bcl-2+ phenotype up to passage 10. Neither neonatal nor normal adult skin fibroblasts expressed either antigen but could be induced to express p53 by exposure to adriamycin. Keloid lesions and keloid fibroblasts were found to have lower rates of apoptosis than normal controls. Keloid fibroblasts displayed enhanced apoptosis rates in response to hydrocortisone, gamma interferon, and hypoxia treatment as compared with normal adult fibroblasts. Focal dysregulation of p53 combined with upregulation of bcl-2 may help produce a combination of increased cell proliferation and decreased cell death in the younger, hypercellular areas of the keloid. This phenotype is reversed in the older areas of the keloid and may prevent malignant degeneration, thus favoring normal apoptosis as evidenced by prominent fas expression.

Adult↗

PubMedDate not supplied

An experimental study about the incorrect electrophysiological evaluation following peripheral nerve injury and repair.

OBJECTIVE: This experiment was designed to explore the reasons of incorrect electrophysiological evaluation following peripheral nerve repair. METHODS: Twenty-four New Zealand white rabbits were used and divided into 2 groups. The first group of animals underwent severance of gastrocnemius muscle nerve and only the medial branch of the nerve was anastomosed. The second group of rabbits underwent severance of the muscle nerve as well as sural nerve, then the proximal end of the sural nerve was anastomosed to the distal end of the muscle nerve. Electrophysiological and morphological methods were used to study these models 3 months after the operations. RESULTS: Electrophysiologic comparison of muscle action potential for group A and B showed a significant difference in the values (p < 0.05). Morphologic studies showed that the muscle weights of group B were significantly lower than those of group A, but the myelin thickness failed to show any statistical difference between the two groups. CONCLUSION: Results suggested that one of the sources causing incorrect electrophysiological evaluation could be misdirected regeneration, resulting from a sensory fascicle anastomosing to a motor one or vice versa. The unfunctional regeneration showed low values of muscle action potentials (p < 0.05) as well as excessive fibrillation potentials, and marked atrophy of the muscles (p < 0.05).

Anastomosis, Surgical↗