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Biomedical subjects

Z Horvat

Publications and source records attributed to Z Horvat.

44 records · Page 3Linked to original sources
PubMedDate not supplied

[The mastocytosis syndrome].

A female patient with the history and clinical signs suggesting cutaneous and systemic mastocytosis is reported. The diagnosis of cutaneous mastocytosis was confirmed by the Darier's sign as well as by histologic analysis of the skin. An X-ray film of the bones showed an infiltration of the mast cells into the skeletal system what was also cytologically and histologically proven. The patient was treated only symptomatically because of the benign course of the disease. A current literature data on mastocytosis syndrome are discussed.

Female↗
PubMedDate not supplied

[Etiopathogenesis of progressive systemic sclerosis].

Progressive systemic sclerosis (PSS) is a systemic disease of connective tissue involving the skin and internal organs characterized by fibrotic and degenerative changes. The disease is usually progressive, incurable and always leads to death. Several hypotheses about the etiopathogenesis of PSS exist which try to explain the cause of morphological changes of the connective tissue. The first theory advocates evolution of the primary lesion within the blood vessels, the second considers the primary event to be an abnormality of collagen metabolism manifested by fibrosis. The third postulates on an autoimmune basis for the disease, and the fourth is based on the disfunction of autonomic nervous system. All the theories are partly linked and represent the morphological, biochemical and immunological aspects of the pathogenesis of this disease.

Humans↗
PubMedDate not supplied

[Immunoglobulins in serum and seminal fluid in patients with sperm agglutination].

Serum immunoglobulins and immunoglobulins in the seminal fluid were determined in 32 men with normospermia without agglutination and in 37 men with normospermia with agglutination. In the seminal fluid also secretory IgA and the secretory component were recorded. The values of serum immunoglobulins were more or less the same. So were the IgG values in the seminal plasma of both groups. IgA was found more frequently in the seminal plasma of patients with agglutination. IgM was not found at all. Secretory IgA and the secretory component were for the most part found in the seminal plasma of patients with normospermia and agglutination. The finding of secretory IgA and the secretory component gives an insight into the local synthesis of sperma-antibodies.

Humans↗
PubMedDate not supplied

[Immunoglobulins and complement in pregnant women with EPH gestosis (author's transl)].

In pregnant women with EPH gestosis immunoglobulins in the serum, urine, amnionic fluid, and the umbilical cord serum were determined. The complement value was determined only in mother's serum. The control group consisted of pregnant women without any pathologic changes in the course of pregnancy and with a normal delivery. All children were normal. In the sera of pregnant women with EPH gestosis low IgG and IgM and normal IgA value were recorded. The total hemolytic activity of the complement was within normal, while the C3 component values was somewhat decreased. The finding of decreased IgG values could be explained, partly, by the permeability of the kidney and--the increased concentration of IgG in the urine and partly by the IgG binding into immunocomplexes. The decreased IgM values are assumed to be due to the IgM binding into EPH immunocomplexes. Normal complement values in EPH gestosis do not indicate an active immunologic reaction. Of special interest is the increased IgM level in the serum of the umbilical cord of children from women with EPH gestosis, which remains inexplicable but might suggest an intensified immunological challenge in the fetus.

Complement System Proteins↗
PubMedDate not supplied

[Results of surgical treatment of ruptured abdominal aortic aneurysms].

This paper analyzes results of 5-year surgical treatment of patients with ruptured abdominal aorta aneurysms (1991.-1995.) at the Clinic for Vascular and Transplantation Surgery of the Institute of Surgery in Novi Sad. 105 patients with abdominal aorta aneurysm underwent surgery, whereas in 31 patients there was a suspicion of rupture and it was confirmed by US and CT examination. One of basic factors to decrease mortality in these patients is early diagnosis and surgery before hemorrhagic shock occurs. Results in hemodynamic stabile patients with blood pressure over 100 mmHg and regular diuresis are much better with mortality of 20%. In order to estimate the correlation of hemodynamic state and outcome of the operation, patients were divided into three groups--hemodynamic stable with blood pressure over 100 mmHg and regular diuresis at admission: hemodynamic unstable patients with signs of mild or moderate shock and blood pressure under 100 mmHg and without initial diuresis which was regulated at the beginning of therapy and hemodynamic unstable patients in severe shock and unmeasurable blood pressure. The highest survival rate (10% mortality) and the least complications occurred in the first group of patients. The total mortality of patients after surgery was 48.48%. Timely diagnosis, suspicion of rupture and adequate first and with urgent transfer to a competent surgical institution are key factors in treatment of this disease and its outcome.

Aged↗