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Biomedical subjects

Z Gottesfeld

Publications and source records attributed to Z Gottesfeld.

At least 55 records · Page 3Linked to original sources
PubMed1979

Kainic acid-induced neurotoxicity in the striatum: a histofluorescent study.

Histochemical observation of catecholamine terminals in the striatum following kainic acid injections revealed a 'sphere of influence' which contained an increased intensity of dopamine fluorescence as well as non-specific tissue destruction at the injection site. The area of involvement was approximately 50% of the striatum and varied somewhat at any one dose range depending upon the site of injection. It is suggested that destruction of regulatory neuronal systems (cholinergic, GABAergic, peptidergic, etc.) results in a net increase of dopamine in the sphere of kainic acid influence.

Animals↗
PubMed1976

Effect of lithium and other alkali metals on brain chemistry and behavior. II. Intracranial self-stimulation behavior.

Rats implanted with bipolar electrodes aimed at the medial forebrain bundle (MFB) were trained to self-stimulate. Six daily injections of 2 mEq/kg of the chloride salts of Li+, Rb+ or Cs+ were administered and the rate of intracranial self-stimulation (ICSS) was recorded. Lithium caused a reversible decrease in ICSS rate, beginning on the second day and returning to pretreatment rate on the fourth day of injections. The decrease was more pronounced in animals with high baseline rate (over 500 responses/10 min) than in low responders. Rubidium enhanced ICSS rate whereas cesium had no effect. These results agree with other accumulating data showing the opposite effects of Li+ and Rb+, but their relevance to effective disorders is not clear.

Affective Symptoms↗
PubMed1976

Effect of lithium and other alkali metals on brain chemistry and behavior. I. Glutamic acid and GABA in brain regions.

Glutamic acid and GABA concentrations were measured in brain areas of rats injected with the chloride salts of Li+, Na+, K", Rb+ or Cs+ for 5 days. Regional changes in brain glutamic acid and GABA were found in animals after lithium, rubidium or cesium, but not potassium, compared to sodium treatments. Increased glutamic acid and GABA levels, caused by lithium and rubidium, were found in brain structures (hypothalamus and amygdala) known to be involved in emotional behavior. Whether these changes are associated with the effective use of lithium and, perhaps, of rubidium in affective disorders remains obscure.

Affective Symptoms↗
PubMed1975

The gamma-aminobutyric acid system in rat cerebellum during cannabinoid-induced cataleptoid state.

Repeated, but not single, intraperitoneal injections of delta1,6-tetrahydrocannabinol (delta1,6-THC) 20 mg/kg to rats administered daily for two weeks, produced increased gamma-aminobutyric acid (GABA) concentration and decreased glutamic acid decarboxylase (GAD) activity in the cerebellum, as well as enhancement of [3H]-GABA uptake by cerebellar crude synaptosomes. It seems that the motor impairment elicited by delta1,6-THC was not associated with the GABA system, but presumably might be related to changes in brain excitability.

Aminobutyrates↗