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Z G Bar

Publications and source records attributed to Z G Bar.

5 recordsLinked to original sources

Drug-induced post-surgical haemorrhage resulting from trimethoprim-sulphamethoxazole. A case report.

A case of life-endangering post-operative haemorrhage due to thrombocytopenia resulting from administration of trimethoprim-sulphamethoxazole is described. Withdrawal of the drug led to complete recovery. This side effect should be kept in mind, especially in patients scheduled for surgical intervention. As thrombocytopenia may develop insidiously and gradually, it is highly recommended to perform full blood tests immediately prior to surgery and repeat them in the post-operative period.

Aged

An investigation of the role of lactic acid production in the causation of metabolic acidosis resulting from raised intracranial pressure in rabbits.

Intracranial pressure (ICP) was acutely raised in anaesthetized rabbits by the injection of saline into the cisterna magna. The raised ICP was maintained at 200 mm Hg for 3 min after which it was allowed to return to baseline values. The profound metabolic acidosis produced (mean base deficit reaching 17.99 +/- SD 4.06 mmol/1 30 min after raised ICP) was found to be in part related to an increase in arterial blood lactate (from mean 7.04 +/- SD 3.26 mmol/l before raised ICP to mean 13.57 +/- SD 5.28 mmol/l 30 min after raised ICP). It would appear that systemic sympathetic nervous system discharge consequent upon raising ICP results in intense vasoconstriction and thus an increase in anaerobic metabolism and inorganic acid production.

Acidosis

Zeroing the CVP.

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Central Venous Pressure

The armlift test. An alternative to the headlift test for assessing recovery from neuromuscular blockade.

The armlift test was assessed as an alternative to the headlift test for recovery from neuromuscular blockade. Forty comparisons of inspiratory force, duration of arm-lift and duration of headlift were performed in 27 intubated patients after anaesthesia, which included the use of non-depolarising neuromuscular blockade. Patients' ability to keep one arm raised (with the elbow clear of the bed) correlated well with inspiratory force (r = 0.67). All patients capable of an armlift duration of 45 seconds or more were also found to have an inspiratory force of at least -2.5 kPa and were safely extubated. The headlift test was found to be less discerning (r = 0.34) and of 40 determinations of headlift and inspiratory force there were 18 false negatives and two false positives.

Adult