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Z Dreznik

Publications and source records attributed to Z Dreznik.

At least 37 records · Page 2Linked to original sources
PubMed1988

Decompensated ureteropelvic junction obstruction in renal allograft.

We report a case of complete obstruction at the ureteropelvic junction in a renal allograft 6 months after related kidney transplantation. Surgical treatment consisted of a Foley nondismembered Y-V pyeloplasty. Although the donor harbored undetected bilateral, mild, ureteropelvic junction stenosis, as established by review of the excretory urogram that was performed before nephrectomy, the remaining kidney functioned well, as confirmed by renal function and morphological appearance on a repeat excretory urogram. The possible mechanisms of ureteropelvic junction decompensation, the most crucial of which appears to be autonomic denervation of the allograft, are discussed.

Adult↗
PubMed1988

Rectovaginal fistula: initial experience.

Rectovaginal fistulas are not common, but the associated symptoms can be emotionally and physically disabling. The authors report their experience of 10 patients with a diagnosis of rectovaginal fistula, seen between December 1982 and July 1986. The women ranged in age from 28 to 74 years. All complained of passing feces or flatus, or both, through the vagina. In the majority of cases, fistulas were present for longer than 6 months before surgical repair. The fistulas were due mainly to trauma. Endorectal advancement flaps were used in seven patients with excellent results. Small fistulas due to obstetric trauma may heal spontaneously, so in these cases a 6-month waiting period before operation is recommended. However, fistulas due to inflammatory bowel disease will not heal spontaneously and should be repaired as soon as the patient's condition is optimal.

Adult↗
PubMed1985

Antibacterial activity of the pancreatic fluid.

The antibacterial activity of canine pancreatic fluid was investigated in an attempt to understand the resistance of this organ, when intact, to ascending bacterial infections. The pancreatic fluid demonstrated bactericidal activity against Escherichia coli, Shigella species, Salmonella species, and Klebsiella pneumoniae; bacteriostatic activity against coagulase-positive and coagulase-negative staphylococci and Pseudomonas aeruginosa; and fungistatic activity against Candida albicans. There was no demonstrable antibacterial activity against Bacteroides fragilis and Streptococcus faecalis. The antibacterial activity was dialyzable and pH dependent, but independent of heat, the activity of several digestive pancreatic enzymes, and the bacterial inoculum. Electron micrographs of Escherichia coli exposed to pancreatic fluid did not demonstrate changes in the bacterial cell wall. Tracer studies of susceptible bacteria demonstrated decreased leucine uptake when briefly exposed to pancreatic fluid. The antibacterial activity was found by column chromatography to be a small molecular peptide. It is likely that pancreatic antibacterial factors protect the pancreas from ascending bacterial infections and operate along with other factors in the homeostasis of the upper small bowel flora.

Animals↗
PubMed1985

Free pleuroperitoneal liquid movement indicating diaphragmatic tear.

An unusual radiological feature, not mentioned in the literature, is reported. It has been observed in a patient with traumatic rupture of the diaphragm associated with intra-abdominal bleeding. This injury produced a free pleuroperitoneal movement of liquid demonstrated in the supine and erect chest radiographs. Since there is an associated abdominal injury in most cases of rupture of the diaphragm, this radiological sign might be more common. The importance of supine and erect chest radiography is reinforced in cases of multiple injuries.

Child↗
PubMed1983

Extra-appendicular carcinoid tumors of the gastrointestinal tract.

During the years 1958-1978, seventeen patients were treated for extra-appendicular carcinoid tumors of the gastrointestinal tract in Tel-Hashomer and Belinson hospitals. Most of the tumors were located in the colon (eight cases) and in the rectum (four cases). A direct correlation between the tumor size and invasiveness has been noted, with distant metastases in eight of 12 patients with tumors more than 2 cm in size. Gastrointestinal bleeding was the most frequent clinical symptom, whereas the "carcinoid syndrome" appeared only in three patients. Curative surgery was performed in six patients, palliative procedure in two cases, explorative laparotomy was performed in four cases, and in two patients diagnosis was made in postmortem examination. Eight of the 17 patients (47%) had distant metastases at the time of the diagnosis, and six of the 15 operated patients (40%) died during the first year after the operation. The malignant nature of these tumors, together with the high incidence (23%) of associated malignant neoplasms is stressed. Radical resection is advocated in the cases where the tumor's size is more than 2 cm or in the presence of muscular invasion.

Adult↗
PubMed1983

Effect of radiofrequency hyperthermia and chemotherapy on primary and secondary hepatic malignancies when used with metronidazole.

Hyperthermia is selectively toxic to neoplastic tissue. Since August 1981, 357 patients with incurable tumors in various body areas have been treated with chemotherapy and radiofrequency hyperthermia (RFHT) with adjuvant metronidazole at this center. Of this group, the cases of 102 patients with hepatic tumors are reported here. Patients received one to ten treatment courses, each course consisting of two to five daily RFHT sessions. Systemic temperature rose 0.6 +/- 0.3 degrees C during treatment, and tumor core temperature (measured by percutaneous transhepatic thermistor) reached 39.5 +/- 1.2 degrees C in 38 monitored patients. Results have been encouraging; in particular, among 15 patients with newly diagnosed colorectal metastases limited to the liver (and as yet untreated for their secondary disease), there has been objective partial tumor regression in 66.7%. Side effects have been few. Skin burns and subcutaneous fat necrosis were seen in 3.9% and 13.7% of patients, respectively. Tumor temperature is difficult to measure reliably and does not correlate with machine power or tumor response. A phase III trial is currently underway to determine the efficacy of RFHT and chemotherapy for patients with hepatic metastases from colorectal adenocarcinoma.

Adult↗
PubMed1983

The effect of radiofrequency hyperthermia and chemotherapy upon human neoplasms when used with adjuvant metronidazole.

It appears that metronidazole causes an increase in tumor core temperature above that achieved with RFHT alone, by an as yet undetermined mechanism. Furthermore, radiofrequency hyperthermia, in combination with chemotherapy, can produce objective evidence of tumor repression in 30 to 50 per cent of the patients with metastatic cancer. These results justify proceeding to a randomized prospective trial of RFHT and chemotherapy in specific human neoplasms. Such a study is currently being undertaken at this center.

Adult↗
PubMed1982

Gentamicin and cefsulodin efficacy in a rat abscess model.

The pharmacokinetics and therapeutic efficacy of gentamicin and cefsulodin were studied in an abscess model in the rat induced by Pseudomonas aeruginosa and a foreign body. Both agents reached therapeutic concentrations in the abscess fluid and its ultrafiltrate and persisted longer in the abscess fluid than in blood. Gentamicin did not prevent the development of abscesses or reduce the bacterial inoculum when administered immediately following the induction of the abscesses. Cefsulodin sterilized 82.7 per cent of abscesses in 61.5 per cent of injected rats. Low oxygen tension present in the abscess was probably responsible for the inefficacy of gentamicin in this model, while not significantly diminishing the antibacterial activity of cefsulodin.

Abscess↗
PubMed1980

Carcinoma of the breast in women 30 years of age or younger.

Between 1960 and 1975, 20 women aged 30 years or younger and with carcinoma of the breast were treated at the Chaim Sheba Medical Center. Eight are alive four to 12 years after the primary operative treatment, and 12 have died. The most important factor affecting the ultimate prognosis was the presence of metastasis in axillary nodes, which was found in 70 per cent of the women at surgery. On the other hand, slowly progressing circumscribed tumors of the medullary and intraductal types were more frequently found, occurring in six of the patients. This fact seems to improve the prognosis. Hence, the overall survival rate of women who are 30 years old or younger with carcinoma of the breast is comparable to that of women in other age groups with the same disease.

Adult↗