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Biomedical subjects

Z Domljan

Publications and source records attributed to Z Domljan.

At least 37 records · Page 2Linked to original sources

Influence of age on quantitative sacro-iliac joint imaging.

Computer processing of sacro-iliac (S-I) joint scintigrams represents a significant contribution to the diagnostic workup of this area. The S-I index is calculated as the ratio between the total number of counts in the region of interest placed on the S-I joint and an identical region placed on the sacrum. S-I indexes were determined in a group of 70 patients aged 13-77 years to establish the influence of age on normal index values. Our results indicate that S-I index values are age dependent. The study was performed 2 h post-injection but the possibility exists that this is not the optimal time interval.

Adolescent↗

Double-blind crossover comparison of piroxicam and indomethacin in rheumatoid arthritis.

This 10-week, double-blind, crossover study compared piroxicam (20 mg administered once daily) and indomethacin (25 mg administered three times daily) in patients with rheumatoid arthritis. In the 30 patients evaluated, both drugs produced statistically significant improvement after 4 weeks compared to placebo in all parameters measured with the exception of joint swelling and 10 m walking time. Piroxicam provided greater improvement with respect to the severity of pain, joint tenderness and restoration of motion, and was significantly more effective than indomethacin in reducing the consumption of paracetamol and in improving morning stiffness. Both drugs were equally effective in improving the remaining parameters measured. Roughly, two-thirds of the patients considered piroxicam to be the more effective agent. With both drugs side effects were mild and infrequent.

Anti-Inflammatory Agents, Non-Steroidal↗

Double-blind crossover comparison of piroxicam and indomethacin in rheumatoid arthritis.

This 10-week, double-blind, crossover study compared piroxicam (20 mg given once daily) and indomethacin (25 mg given three times daily) in patients with rheumatoid arthritis. In the 30 patients evaluated, both drugs produced statistically significant improvement after 4 weeks compared to placebo in all measured parameters with the exception of joint swelling and 10 m walking time. Piroxicam tended to provide greater improvement in the severity of pain and joint tenderness than indomethacin, while both drugs were equally effective in improving morning stiffness, grip strength, and range of joint motion, and in decreasing paracetamol consumption. Nevertheless, roughly two-thirds of the patients considered piroxicam to be the more effective agent. With both drugs side effects were mild and infrequent.

Adolescent↗