Search PubMed⌕ Search

Biomedical subjects

Z Antalóczy

Publications and source records attributed to Z Antalóczy.

At least 19 recordsLinked to original sources
PubMed1994

Connection between right ventricular pressure and the ECG.

According to the literature, electrocardiographic signs of right ventricular hypertrophy have low sensitivity. The cause of this low sensitivity may be attributed to the original studies that were performed mostly in children with hypoplastic left ventricles or congenital heart abnormalities. In adulthood cases of normal or hypertrophic left ventricles, electrocardiographic right ventricular hypertrophy can only be detected during the late phase of ventricular depolarization. Two hundred four adult cardiac patients with complete noninvasive and invasive records were systematically studied by conventional and vectocardiographic methods. The terminal QRS (S wave) of the standard lead I has proved to be informative for detecting electrocardiographic signs in the presence of elevated right ventricular pressure. In cases of chronic right ventricular pressure overload (right ventricular hypertrophy) the terminal depolarization QRS vectors pointed posteriorly and to the right; therefore, a characteristic terminal S wave was represented in the standard lead I. If right and left ventricular hypertrophy were simultaneously present, the same resultant vectors pointed posteriorly and slightly to the left. In these cases, notching of the declining phase of the R wave was frequent, and a flatness of the terminal R wave portion was characteristic. The latter electrocardiographic sign has been called "simultaneous overloading of both ventricles" by the authors. The clinical utility of the new signs have also been proved by statistical methods.

Adult↗
PubMed1993

[Clinical significance of incomplete right bundle branch block].

In authors' opinion the majority of the physicians speak about an incomplete right bundle branch block in cases of a terminal r'wave in lead V1 of the ECG, when the QRS complex is not wider than 0.12 sec. These ECG anomalies are not properly separated in the literature, either. Authors define 4 groups whose separation is possible by the analysis of leads V1 and V2. 1. Right ventricular conduction defect--the ECG width is 0.09-0.13 sec. This picture generally signs normal or only slight higher right ventricular pressure. 2. Real incomplete right bundle branch block--the terminal vector directs forward only in this group and it causes also an r' in V2 next to the high R' in lead V1. This group can be harmless, only a conduction defect, but it can mean an advanced stadium of serious right ventricular systolic or diastolic overloading, too. 3. Right ventricular diastolic overloading--the QRS width is normal. We saw this picture in slight forms of atrial septal defect. One of our conclusions was that in case of normal V1 a haemodynamic significant ASD I or ASD II can be excluded. 4. Normal variant: normal QRS width and only a very low r' in lead V1. It was seen in young patients or in patients with flat chest. Authors remark that this pattern can possibly be seen in childhood or in case of inexact ECG (V1) registration.

Bundle-Branch Block↗
PubMed1993

A new possibility in the study of heart activation: the nondipolar body surface map.

The main goal of the present paper is to study the temporal and spatial course of cardiac electrical activation noninvasively, and to acquire more information than can be obtained from conventional methods, such as electrocardiography or vectorcardiography. The single moving resultant heart dipole is determined from a set of measured body surface potential maps before dipolar and nondipolar theoretical body surface potential maps are calculated. These three kinds of maps are studied together in different electro-cardiological situations (normal, left and right bundle branch block, and necrosis) during the entire cardiac cycle. The set of nondipolar maps is suitable for localizing and following the changes of minor positivity and negativity to detect small extensions of infarcts.

Bundle-Branch Block↗
PubMed1992

Anti-anginal effect of Tenormin (atenolol).

The anti-anginal effect of Tenormin (atenolol) has been examined besides placebo control by single blind method in 20 patients with ischaemic heart disease, suffering from stable effort angina proved by coronarography. It has been observed that atenolol significantly decreases the weekly number of anginal attacks, and the amount of sublingual nitroglycerin consumption. It has been proved that atenolol successfully prevents the exercise-induced elevation of blood pressure and heart rate, increases exercise tolerance, decreases myocardial O2 consumption. The place among beta-blockers of the cardioselective, low lipophilic atenolol, which lacks membrane stabilizing and partial agonist activity, has been discussed. The administration of a single daily dose (one 100-mg tablet), selective cardiac effect, lack of unwanted side-effects (cold extremity, nightmare, insomnia, etc.) are the advantages of the drug.

Adult↗
PubMed1991

[Clinical value of body surface mapping in the diagnosis of ischemic heart disease].

A series of 137 patients suffered in clinically documented angina pectoris were analyzed by 12-lead exercise ECG, exercise body surface potential mapping and exercise thallium scintigraphic methods and the results were compared to that of selective coronary angiography and left ventriculography. If coronary artery stenosis were considered to be significant in the presence of more than 70% vessel narrowing, the sensitivity figures were 76, 93 and 88% for exercise 12-lead ECG, exercise body surface potential mapping and exercise thallium scintigraphy, respectively. In considering 50% coronary artery narrowing to be significant, the same figures were 78, 94 and 89%. Specificity figures at the same order were 59, 65 and 80% for more than 70%, and 64, 70 and 88% for more than 50% coronary obstructions. Exercise body surface potential mapping and exercise thallium scintigraphy applied parallelly gave a sensitivity of 100% and specificity of 53%. False-negative and false-positive exercise body surface potential mapping and thallium scintigraphic tests were analysed taking into consideration left ventricular function indices and respective patients. The authors suggest that the outstanding high sensitivity of the above mentioned two tests applied parallelly reveals that they highlights partially different aspects of coronary artery disease, and that is why the overlapping between the methods is relatively small. The majority of false-positive tests characterize a pathological state, and in these cases the exact diagnosis should be cleared up by other noninvasive/invasive methods.

Angina Pectoris↗
PubMed1990

Comparative evaluation of the effect of balloon dilatation by exercise precordial mapping and exercise 201-thallium scintigraphy.

Precordial exercise electrocardiographic mapping and exercise 201-thallium scintigraphy were simultaneously used on sixteen patients before, shortly after and three months after percutaneous transluminal coronary angioplasty (PTCA) to evaluate the immediate and late results of the intervention. In spite of the limited number of observations, positive exercise precordial mapping and or a reversible 201-thallium perfusion defect after PTCA seem to be indicative of failure of balloon dilatation or of development of restenosis in a given coronary artery. "Reverse minimum", that is the minimum in the resting precordial map which disappears on exercise, may be a sign of segmental coronary artery occlusion and well functioning collateral supply.

Adult↗
PubMed1989

[Cardiac and cardiopulmonary changes in systemic lupus erythematosus].

(SLE) One hundred patients suffering from systemic lupus erythematosus (SLE) were examined by clinical, non invasive cardiological, radiological and laboratory methods. Valve diseases were revealed by M-mode echocardiographic examination in 17 patients. 14 patients had various conduction disturbances. Out of the remaining 83 patients not having any valve disease, systolic dysfunction of the myocardium was detectable in 17 persons and pericardial effusion in 3 persons. Spirometric alterations have been found in 64 persons and cor pulmonale has been diagnosed in 8 persons.

Echocardiography↗
PubMed1989

Antianginal effects of atenolol and pindolol in patients with stable effort angina pectoris.

A double blind, randomised crossover study with 20 patients was performed to compare the antianginal effects of atenolol 100 mg once daily and pindolol 5 mg thrice daily. After a placebo run-in period, 2 treatments were given for 2 wk each. The number of anginal attacks and the nitroglycerin (NTG) consumption were determined. During bicycle exercise testing, the systolic blood pressure (BP), heart rate (HR), double product and exercise tolerance were measured. Both drugs reduced the number of anginal attacks and NTG consumption relative to the placebo, with atenolol being more effective than pindolol. During exercise, both beta-blockers produced a slight increase in BP and HR compared to the placebo. HR attained with atenolol was lower than pindolol at the same workload. The total duration of exercise and the maximal tolerated workload were greater in atenolol than pindolol experiment. The special properties of beta-blockers, such as cardioselectivity or intrinsic sympathomimetic activity (ISA), may have clinical importance in the treatment of angina pectoris.

Adult↗
PubMed1988

Correlation of electrocardiologic and pathologic findings in 100 cases of Q wave and non-Q wave myocardial infarction.

Of 100 cases of acute myocardial infarction as shown on autopsy, 55 cases were transmural infarcts and 45 were subendocardial. Pathologic Q waves appeared in 67% of the cases of transmural infarct and in 30% of subendocardial infarct. In transmural infarcts, Q wave infarcts occurred twice as frequently as non-Q wave infarcts. In the cases of subendocardial infarcts just the opposite was observed: non-Q wave infarcts had double the frequency of Q wave infarcts. In spite of this, when a myocardial infarct is characterized strictly by electrocardiology, it should be described by only the accurate terminology of Q wave infarct or non-Q wave infarct. To distinguish with certitude between subendocardial infarct and transmural myocardial infarct on the basis of the ECG does not seem possible. Q wave infarct as "transmural" and non-Q wave infarct as "subendocardial" does not correspond to the pathologic evidence.

Aged↗
PubMed1988

Comparative study on the short-term effects of angiotensin converting enzyme inhibitors (Lopirin, SQUIBB and Tensiomin), and dihydralazine in chronic cardiac failure.

The authors have compared the short-term effect of two captopril (ACE inhibitor) preparations namely the Lopirin (SQUIBB) and Tensiomin (EGIS) and dihydralazine as well as placebo in 15 patients with severe heart failure (NYHA III-IV, class). In case of 8 patients with NYHA IV, functional class the short-term effect of the combined therapy of dihydralazine and Lopirin and dihydralazine and Tensiomin as well dihydralazine and placebo have been compared. The underlying disease was dilated cardiomyopathy (DCM) and ischaemic heart disease (IHD). At the end of the treatment with different drugs and placebo the clinical signs of heart failure (complaints and physical status) and the echo and mechanocardiographic parameters of left ventricular function were assessed. The parameters, apart from the clinical signs, have been evaluated in double blind fashion. Compared to placebo all the three drugs i.e. dihydralazine, Lopirin as well as Tensiomin have decreased significantly the NYHA classes, influenced favorably the non-invasive parameters of left ventricular function and decreased blood pressure. As to the dihydralazine, it improved the left ventricular ejection function and the clinical state of the patients with DCM in a higher degree than the two ACE inhibitors did. The effect of Tensiomin and Lopirin was the same in every respect. Both have influenced more favourable the complaints and physical state of patients with IHD than dihydralazine has. The left ventricular filling pressure, the double product (heart rate x wall tension) indicating the myocardial oxygen demand were more reduced in their effect than in that of dihydralazine. Unlike dihydralazine both decreased the heart rate. Administering one of the two ACE inhibitors to the dihydralazine beneficial additive effects have been experienced; the NYHA classes, the heart rate, the left ventricular wall tension and the double product diminished. The authors, on the bases of the results, consider Tensiomin and Lopirin as equivalent in their effect. In their opinion the administration of these drugs mean a new, efficient way of therapy, first of all in cases of heart failure caused by IHD. In the most severe cases they suggest a trial with the combined dihydralazine-ACE inhibitor therapy.

Adult↗
PubMed1986

Detection and localization of ventricular preexcitation in Wolff-Parkinson-White syndrome (comparative study with body surface mapping).

21 patients with Wolff-Parkinson-White (WPW) syndrome were investigated through radionuclide imaging and body surface mapping. Ventricular preexcitation was localized by display of identical phase ventricular regions (phase display). In 79% of the cases radioisotope and body surface mapping methods have identical results for the site of preexcitation. In two patients of the control group (10 patients with Lown-Ganong-Levine (LGL) syndrome), false positive outside-of septum ventricular preexcitation was detected, i.e. an 80% specificity. It is concluded that phase display might be a suitable method in the diagnosis of WPW syndrome. The sensitivity of this method can be improved using several views.

Adult↗