Plasma nitrate and nitrite levels of patients with eating disorders.
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Adult↗
Biomedical subjects
Yutaka Ono
Publications and source records attributed to Yutaka Ono.
Cytochrome P450 2D6 polymorphism and character traits.
OBJECTIVE: It has been suggested that cytochrome P450 2D6 (CYP2D6) is involved in dopamine metabolism within the brain. The dopamine system is suggested to play a role in determining normal character. The purpose of this study was to examine whether character traits are dependent on cytochrome P450 2D6 activity. METHODS: We investigated the association between temperament and CYP2D6 gene polymorphism. The subjects were all Japanese and the polymorphism genotyped in the present study was CYP2D6*10. Character traits were assessed using the Temperament and Character Inventory. RESULTS: There was no overall or specific association between personality traits and the CYP2D6*10 allele and genotype frequencies. CONCLUSIONS: The present results do not support the hypothesis that CYP2D6 activity affects temperament and character.
Character↗
[Cognitive therapy].
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Anxiety Disorders↗
Does the morphology of the iliolumbar ligament affect lumbosacral disc degeneration?
STUDY DESIGN: An anatomic study of the iliolumbar ligament was performed in association with lumbosacral disc degeneration. OBJECTIVES: To determine whether the morphology of the iliolumbar ligament contributes to lumbosacral disc degeneration. SUMMARY OF BACKGROUND DATA: There have been few reports concerning the clinical significance of the iliolumbar ligament. METHODS: We dissected 25 male and 27 female cadavers and measured the length and cross-sectional area of the anterior and posterior bands of the iliolumbar ligament. The specimens were classified into three groups based on the grade of L4-L5 and L5-S1 disc degeneration: the L4-L5 disc was more degenerated than the L5-S1 disc (group L), the L4-L5 disc was less degenerated than the L5-S1 disc (group S), and both discs were equally degenerated (group E). The results were statistically compared among the three groups. RESULTS: The length of the posterior bands and the summation of the length of the anterior and posterior bands were significantly shorter in group L than in group S, and the cross-sectional area of the posterior bands and the summation of the cross-sectional area of the anterior and posterior bands were significantly larger in group L than in groups S or E in the male cadaver specimens. CONCLUSION: If the iliolumbar ligaments (especially the posterior band of the ligament) of a male patient are short and have a large cross-sectional area, the lumbosacral junction can be stabilized by the ligaments, with the L5-S1 disc being protected from degeneration. The L4-L5 disc may be prone to degeneration.
Adult↗
Quality of life and its correlates in a community population in a Japanese rural area.
Correlations of three aspects of quality of life (QOL) (health perception, life satisfaction, and self-confidence) with personality traits and early experiences were examined. Quality of life aspects were examined using 220 inhabitants in a rural community in Japan. Health perception was better among men than among women. Life satisfaction and self-confidence were better in people aged 55 or over than in those under 55. Among the current predictor variables, the Eysenck Personality Questionnaire neuroticism score was correlated with poor life satisfaction in the younger women; the extraversion score with the older women's health perception, the older men's life satisfaction, and the women's self-confidence; and the psychoticism score with the older men's life satisfaction. Among early life predictors, self-confidence was lower among those older men who had reported early parental loss. Childhood paternal overprotection was correlated with poor health perception in younger people and with good health perception in older women. Some negative life events experienced during childhood were correlated with poorer QOL measures in some subgroups, while positive life experiences were correlated with the older women's life satisfaction. These findings suggest that the three aspects of the QOL are discrete in their psychosocial correlates and that interventions on health education and care should take into account individual's psychosocial attributes.
Adult↗
Failure to maintain the suppressed level of serum testosterone during luteinizing hormone-releasing hormone agonist therapy in a patient with prostate cancer.
A 75-year-old man with metastatic prostate cancer had been treated with goserelin acetate, and prostate specific antigen (PSA) had decreased, but 11/2 years after beginning the treatment of goserelin acetate, PSA was markedly elevated and serum testosterone was at normal level. After castration the serum testosterone was at castrate level and PSA decreased. In the present case, leuprorelin acetate 1-month depot suppressed the luteinizing hormone level in 1 month, even after the patient underwent castration.
Adenocarcinoma↗
The genetic structure of Cloninger's seven-factor model of temperament and character in a Japanese sample.
Theoretical assumptions regarding the genetic and environmental structure of personality proposed in Cloninger's seven-factor model of temperament and character were verified in a Japanese sample by using the twin method. The Temperament and Character Inventory (TCI) was administered to 296 twin pairs ranging in age from 14 to 28 years old. Among four temperament dimensions (novelty seeking [NS], harm avoidance [HA], reward dependence [RD], and persistence [PS]), HA and PS showed significant additive genetic contributions and no shared environmental effect, supporting the original theoretical assumption. NS and RD could be explained by either genetic or shared environmental factors with nonshared environment. All three character dimensions (cooperativeness [CO], self-directedness [SD], and self-transcendence [ST]) could be explained exclusively by additive contributions and no shared environmental effect. Multivariate genetic analysis indicated that there were no significant associations between NS, HA, and RD, as the theory predicts, and the genetic components of PS, SD, and CO were derived from those of the temperament dimensions. The fourth genetic component, which had a substantial load specifically on ST and overlapped with PS, was identified. Although most of the nonshared environmental effects were trait-specific, the phenotypic correlation between NS and HA could be explained by nonshared environmental overlap.
Adolescent↗