Biomedical subjects

Yume Suzuki

Publications and source records attributed to Yume Suzuki.

8 recordsLinked to original sources

PubMed2005

Visual event-related potentials under different interstimulus intervals in Parkinson's disease: relation to motor disability, WAIS-R, and regional cerebral blood flow.

We have introduced S1-S2 paradigm (task S) as well as oddball paradigm (task O) visual event-related potentials (ERPs) under different interstimulus intervals (ISIs) in Parkinson's disease (PD). ERP measurements were correlated with motor disability, WAIS-R, and regional cerebral blood flow (rCBF). The 'group' influence was characterized by longer latency for P300, N200, and reaction time and decreased P300 amplitude in PD. Both P300 latency and reaction time during task O showed significantly longer latency in longer ISI condition. Our results revealed 'ISI' influence on ERPs during task S and significant correlation between ERPs and rCBF in task S.

Aged↗

PubMed2005

[Treatment of neurological complication due to postgastrectomy vitamin E deficiency].

Although postgastrectomy vitamin E deficiency rarely occurs, it can cause neuromuscular disorder such as neuropathy, myopathy and cerebellar ataxia. We encounter a lot of cases whose serum vitamin E level were decreased after gastrectomy. We evaluated the oral vitamin E intake as a therapy to these cases. The subjects of this study were 11 gastrectomized patients (8 patients had total gastrectomy, 2 subtotal gastrtectomy, 1 partial gastrectomy) with decreased vitamin E. 10 patients had neurological complications such as dizziness, dysesthesia, truncal ataxia. Serum vitamin E increased to normal level in 10 patients and neurological disturbances were improved in 9 patients. The minimum requirement of oral vitamin E intake was 150 mg a day for normalization of serum vitamin E, on the other hand, it decreased with 150 mg intake in some patients. Their serum level increased with 300 mg. We suggest that it is important to check serum vitamin E in gastrectomized patients and oral vitamin E should be supplied over 300 mg for the therapy with vitamin E deficiency.

Administration, Oral↗

PubMed2005

[The therapeutic efficacy in Fisher syndrome].

We studied clinical courses of 15 cases of Fisher syndrome (FS) and examined therapeutic efficacy of plasma exchange (PE), immunoadsorption (IA), intravenous immune globulin (IVIg), and steroid therapy (ST). Compared with other treatments, PE and IA had shortened the peak period of the symptoms, but had not revealed the difference of the duration of illness between one another. As for PE and IA, the short-term effect was seen, but did not show the long-term effect. Though IVIg was done at the early stage, it did not shorten the peak period. So we conclude IVIg for FS to be effective not so equal as PE. However, clinical manifestations were milder in IVIg cases than PE, and there was a possibility that the symptoms of FS became mild by early treatment with Mg. Compared with Guillain-Barré syndrome, it is rare for FS to leave aftereffects and convalescence is good, so the choice of a therapy should be considered with a severity and complications.

Adult↗

PubMed2004

[Vitamin E].

Explore the source record for details and available documents.

Alzheimer Disease↗

PubMed2003

The effect of stimulus-onset asynchrony on human visual event-related potentials during simple and choice reaction paradigms under constant or random conditions.

Visual event-related potentials (ERPs) were recorded during an oddball paradigm (OBP) and a simple reaction paradigm (SRP) to investigate the effect of stimulus-onset asynchrony (SOA) on ERPs under constant and random conditions in nine healthy individuals. NA was obtained by subtracting ERPs for SRP from those to the frequent nontarget of OBP. N2 was obtained by subtracting ERPs to the frequent nontarget from those to the rare target of OBP. N1, P2, and P3 latencies during OBP were shorter, and N1 amplitude of OBP, P1, and P2 amplitude of SRP, and NA amplitude were larger under constant conditions than under random conditions. We suggest that visual information processing is faster and more effective under constant conditions than under random conditions. NA potential related to the pattern recognition processing was significantly interfered with under random conditions, whereas N2 potential related to the stimulus classification was less influenced by the rhythm. The visual selective processing activity was influenced by the SOA with the positive shift of the waveform "20% rare target of OBP-100% target of SRP" under random conditions.

Adult↗

PubMed2003

A study of the early stage of Dysphagia in amyotrophic lateral sclerosis.

In amyotrophic lateral sclerosis (ALS) patients, dysphagia eventually occurs independent of time of onset. We studied dysphagia conditions in the early stage of ALS, principally at the oral phase. Videofluoroscopic and manometric studies were conducted on 11 patients (5 males and 6 females, age range = 47-82 years) who were diagnosed at our Neurology Clinic as having ALS. All patients were able to ingest orally. Swallowing scores on the ALS severity scale were from 10 to 5. In the oral phase of swallowing, abnormal movements of the anterior and/or posterior tongue were recognized in 8 cases. Dysphagia severity tended to be particularly influenced by dysfunction of the posterior tongue. Manometric studies were almost normal in all cases except one. These results suggested that the early stage of dysphagia in ALS was mainly caused by oral dysfunction, and the oral phase disorders began in some cases with a decreased function of bolus transport at the anterior part of the tongue, and in other cases with a deteriorated function of holding the bolus at the posterior part of the tongue. In conclusion, the tongue function of holding the bolus in the oral cavity mainly affects the severity of the early stage of dysphagia in ALS.

Aged↗

PubMed2003

Early sensory information processes are enhanced on visual oddball and S1-S2 tasks in Parkinson's disease: a visual event-related potentials study.

To observe sensory and cognitive information processing in Parkinson's disease (PD), 34 PD patients and 26 controls were investigated. A visual oddball paradigm and an S1-S2 paradigm were employed to record the early (P1, N1, P2) and late (N2, P3) event-related potentials (ERPs) at Cz, Pz and Oz. Results showed: (1) enlarged P1 amplitude at all electrode locations on both tasks, (2) shortened N1 latency and enlarged P2 amplitude at Oz on both tasks, (3) enlarged N1 amplitude at Cz during an oddball paradigm, (4) delayed N2 latency and decreased N2, P3 amplitude on both tasks, and (5) delayed P3 latency and reaction time during the S1-S2 paradigm. Abnormal ERP changes were correlated with worsened scores on Wechsler Adult Intelligence Scale-Revised and motor dysfunction scales in PD. We surmise overactive aspects or failed inhibitory modulation of sensory information processing in the early ERP stage and deficient cognitive information processing during the late ERP stage in PD.

Adult↗

PubMed2002

Visual event-related potential changes in two subtypes of multiple system atrophy, MSA-C and MSA-P.

We investigated the visual event-related potentials (ERPs) in two subtypes of multisystem atrophy (MSA) in 15 MSA-C patients, 12 MSA-P patients, and 21 normal control (NC) subjects. We used a visual oddball task to elicit ERPs. No significant changes were seen in N1 or N2 latency, in either MSA-C or MSA-P, compared with the NC group. An early stage of visual information process related to N1 and a visual discrimination process related to N2 might be preserved in both MSA-C and MSA-P. The P3a peak was more frequently undetectable in MSA than in the NC group. Significant P3a amplitude reduction in both MSA-C and MSA-P suggests impairment of the automatic cognitive processing in both MSA-C and MSA-P. Significant difference was found in P3b latency and P3b amplitude only in MSA-C, compared with the NC group. The result suggests the impairment of the controlled cognitive processing after the visual discrimination process in the MSA-C group. We further investigated the correlation between visual ERP changes and magnetic resonance imaging (MRI) data. Quantitative MRI measurements showed reduced size of the pons, cerebellum, perisylvian cerebral area, and deep cerebral gray matter in both MSA-C and MSA-P, and of the corpus callosum only in MSA-P, as compared to NC group. In both MSA-C and MSA-P, P3b latency was significantly correlated with the size on MRI of the pons and the cerebellum. P3b latency in the whole MSA group was also significantly correlated with the size of the pons and the cerebellum. These results indicate that P3b latency changes in parallel with the volume of the pons and the cerebellum in both MSA-C and MSA-P.

Adult↗