Biomedical subjects
Publications and source records attributed to Yuichi Matsui.
A new technique is reported for complete venous drainage for a left liver with caudate lobe graft when a short hepatic vein and left and middle hepatic veins are located close to each other.
Right-lobe graft has been used most frequently for living donor liver transplantation in adult patients; however, some donors cannot donate their right lobe (according to the Healey and Scroy's terminology) because the remaining residual liver would be too small. A recent study suggested the possibility of right posterior segment graft in these donors. The purpose of this study was to evaluate the feasibility of right lobe or right posterior segment graft with a volumetric analysis. Liver volumetry by computed tomography was performed in 155 consecutive donors, and the volume of each liver segment was calculated. To confirm the reliability of volumetric examination, the estimated graft volume and the actual weight were compared. The average volume ratios of the left lateral segment, left medial segment, caudate lobe, right anterior segment, and right posterior segment were 17%, 14%, 2%, 37%, and 30%, respectively. In 39 donors (25%), the volume ratio of the right lobe was over 70%. Of these donors, 72% had a larger (difference in volume ratio greater than 5%) right posterior segment than left lobe with caudate lobe. The relationship between the estimated volume and actual weight was linear. The present results suggest that right lobectomy carries a potential risk and that the right posterior segment may be useful as an alternative graft from the point of donor's safety.
BACKGROUND: Living donor liver transplantation (LDLT) is now widely performed for adult patients to resolve the critical shortage of organs from cadavers. The objective of this study was to analyze the experience of a single center with adult LDLT. METHODS: Eighty-two consecutive LDLT procedures for adults were divided into 3 groups according to the transplant era and the preoperative condition and indications: all patients between 1996 and 1999 (Group 1, n = 30), good-risk patients between 2000 and November 2001 (Group 2, n = 28), and poor-risk patients (Group 3, n = 24). Up to 1999, left liver graft was used for all patients. Thereafter, right liver was selected only for poor-risk patients. Preoperative status, morbidity, hospital duration, and postoperative graft function and survival rate were examined and compared among the groups. RESULTS: Comparison of groups 1 and 2 revealed a significant difference in the hospital duration and the survival rate. In contrast, the short-term surgical results were comparable between groups 2 and 3. The 2-year survival rates were 84%, 100%, and 88%, respectively. CONCLUSIONS: The present results suggest that our graft selection criteria are acceptable. A small graft can provide satisfactory results when used in good-risk patients and a right liver graft may be beneficial in poor-risk patients.
BACKGROUND/AIMS: The efficacy of operative resection of lesions metastatic to the liver from colorectal or neuroendocrine tumor is well established. However, the appropriate management of liver metastasis from gastric cancer is controversial. We analyzed the prognostic factors in patients who underwent hepatectomy for metastasis from gastric cancer. METHODOLOGY: Retrospective clinical and pathological study in Tokyo Metropolitan Bokutoh Hospital. Ten patients underwent hepatectomy for metastases from gastric cancer out of 1807 patients with gastric cancer between 1981 and 1998. INTERVENTIONS: Clinical investigation and histopathological examination of resected specimen. MAIN OUTCOME MEASURES: Survival, recurrence, liver metastases and lymph node metastases. RESULTS: The 1-, 3-, and 5-year survival rates of these ten patients were 50%, 30%, 20%, respectively. The median survival time was 25 months, and two patients survived longer than five years. The survival time tended to be longer, but not to a significant extent, in patients with no lymph nodal involvement at the primary site (P = 0.067). CONCLUSIONS: Even though it is rare, a survival time of 5-years can be achieved by resection of gastric cancer metastatic to the liver. These results suggest that a patient with liver metastasis from gastric cancer has a greater chance of surviving long-term if there is no lymph node metastasis at the primary site.
BACKGROUND/AIMS: The purpose of the present study was to examine variations in spleen size in adults. METHODOLOGY: The spleen volume was measured by computed tomography in 150 healthy donors for liver transplantation. The correlations between spleen volume and age, gender, body weight and body surface area were analyzed. RESULTS: The mean volume of the spleen was 112 cm3, ranging from 32 to 209 cm3. The spleen volume significantly correlated with age (R = 0.36, p = 0.0002), but not with body weight or surface area. Gender did not influence the variation in spleen size. CONCLUSIONS: A crude normal range stratified by age should provide useful information in the diagnosis of splenomegaly.
A 70-year-old man with double carcinomas of the hilar bile duct and stomach underwent extended right hepatectomy and total gastrectomy with double Roux-en-Y reconstruction in a one-stage procedure 15 days after right portal embolization. The postoperative course was uneventful, and he was discharged 33 days after surgery. This report describes details of the surgical techniques employed in this patient.
Hepatic allograft rejection after liver transplantation remains an important problem. We report a case of corticosteroid and anti-T cell monoclonal antibody-resistant acute cellular rejection in living related liver transplantation. A 57-year-old female received a right liver graft from her daughter for hepatitis C-related liver cirrhosis. Methylprednisolone and tracrolimus were used for immunosuppression. The patient experienced acute rejection 10 days after the operation. Rescue therapy was attempted using high doses of methylprednisolone and then monoclonal antibodies. Deterioration of graft function, however, was not prevented, resulting in graft and patient loss. Graft lost due to refractory acute rejection could also occur in living related liver transplantation, although it should be rare.
Milan criteria are standards for considering the indications of liver transplantation for hepatocellular carcinoma. A 57-year-old man underwent living donor liver transplantation for hepatitis B-related liver cirrhosis and hepatocellular carcinoma. Hepatocellular carcinoma had been treated with percutaneous microwave coagulation therapy and transarterial chemoembolization. Resected specimens revealed a solitary necrotic tumor 5 cm in diameter, which satisfied the Milan criteria. Although the patient survived the operation, he suffered from tumor recurrence in the graft and lung 2 months afterward. Adjuvant chemotherapy had no effect and the patient expired 7 months after transplantation. The present results indicate that a tumor satisfying the Milan criteria does not necessarily guarantee long-term survival after transplantation.
There are few reports of central pontine myelinolysis after living donor liver transplantation. A 59-year-old male received a right liver graft from his daughter for hepatitis B-related liver cirrhosis. Methylprednisolone and tracrolimus were used for immunosuppression. Dysarthria and dysphasia were noted on the second postoperative day. Brain magnetic resonance image taken on the 9th postoperative day revealed a hyperintense area at the center of his pons in T2-weighted images. The symptoms improved spontaneously 1 month after the operation. Central pontine myelinolysis should be included in the differential diagnosis when neurologic manifestations are observed after living donor liver transplantation.
BACKGROUND/AIMS: Right lateral sector (RLS, segments VI and VII according to Couinaud's nomenclature for liver segmentation) graft was introduced as an alternative liver graft. The authors report their surgical techniques for bile duct division in RLS graft harvest. METHODOLOGY: Between January 2000 and December 2001, 11 donors provided their RLS. Intraoperative cholangiography was performed and the anatomy of the upper biliary confluence was confirmed. When the right lateral duct entered the common bile duct (caudal right lateral duct), the duct was divided at its root in situ. In other situations, the right portal branch was first dissected and taped. With the right portal branch pulled cranially, the right lateral duct was dissected from surrounding connective tissues and divided as long as possible. RESULTS: Cholangiography revealed various right lateral duct anatomies, such as entering the right duct (n=6), the left and right bifurcation (n=2), the common bile duct (n=2) and the left duct (n=1). The postoperative course was uneventful in all donors. All of the patients survived the operation. CONCLUSIONS: Careful attention should be paid to bile duct division in donor hepatectomy. The present technique can ensure a safe harvest of RLS graft with a long right lateral duct.