Biomedical subjects

Yucel Kanpolat

Publications and source records attributed to Yucel Kanpolat.

8 recordsLinked to original sources

PubMed2007

Evaluation of platybasia in patients with idiopathic trigeminal neuralgia.

BACKGROUND: Vascular compression of the trigeminal nerve is generally accepted as the primary source causing TN. To date, skull base bone deformity associated with ITN has been reported in only a number of case reports. The aim of the present study was to investigate one such skull base deformity, platybasia, in ITN patients in comparison with a randomized control population. METHODS: Basal angle values reflecting the development of platybasia were measured in 25 patients with ITN and compared with the measurements in 25 control subjects. RESULTS: Basal angle measured to investigate the existence of platybasia was found significantly wider in the ITN group (t = 3.90; P < .001), although platybasia was present in only 10 patients. Moreover, the average angle was also greater in the study group than in the control group, and the difference was statistically significant. Platybasia was found in 10 patients, whereas it was detected in only 2 control individuals; difference in platybasia incidence between the 2 groups was also statistically significant (chi(2) = 7.01; P < .01). CONCLUSION: Our data demonstrated that platybasia affecting the bony walls of the posterior fossa may play an important role in the pathogenesis if vascular abnormalities causing TN.

Aged↗

PubMed2006

A neurosurgical view of anatomical variations of the distal anterior cerebral artery: an anatomical study.

OBJECT: The vascularization pattern of the anatomy of the distal anterior cerebral artery (ACA) remains a subject of debate. The authors provide detailed information about the distal ACA and shed light on issues concerning it that have not previously been adequately discussed. METHODS: Fifty adult human brains (100 hemispheres) were obtained during routine autopsies. Cerebral arteries were separately cannulated and injected with latex. The vascularization patterns of the cortical branches and the variations of the arteries were investigated. The authors found that the distal ACA supplied all the inner surfaces of the frontal and parietal lobes and a median of one third of the outer surfaces. The origin of the arteries from the main trunk and their exit angles affected the vascularization patterns of the hemispheres. The authors redefine controversial terminology regarding the callosomarginal artery. CONCLUSIONS: In each hemisphere, the vascularization pattern of the distal ACA is different to a greater or lesser extent. An awareness of this fact will contribute significantly to surgical interventions.

Anterior Cerebral Artery↗

PubMed2005

Petrous bone osteoblastoma invading the cavernous sinus.

A 45-year old female was admitted complaining of double vision. A CT scan revealed a mass originating from the petrous part of the temporal bone with infiltration of the cavernous sinus. The patient was operated and a subtotal excision of the tumor was achieved. Pathological examination revealed benign osteoblastoma. During an 18 year follow up period, no progression of tumor has been detected.

Bone Neoplasms↗

PubMed2005

Trigeminal neuralgia in a patient with Dandy-Walker malformation.

BACKGROUND: Trigeminal neuralgia may be idiopathic or secondary to a number of cranial pathologies. We report a novel case of trigeminal neuralgia associated with Dandy-Walker malformation, which may be an etiologic factor. CASE DESCRIPTION: A 32-year-old male presented with shock-like pain in the somatosensory distribution of the right trigeminal nerve, which was refractory to all medication. MRI revealed a cystic lesion in the posterior fossa and a hypoplastic vermis. The pain was diagnosed as trigeminal neuralgia and was thought to be secondary to the Dandy-Walker malformation. The trigeminal neuralgia was treated successfully with radiofrequency thermocoagulation rhizotomy (RF-TR). CONCLUSION: Trigeminal neuralgia may be associated with Dandy-Walker malformation, however an etiological relationship is not proven. We suggest that traction on the trigeminal nerve may be significant. The posterior fossa cyst of Dandy-Walker malformation may be a complicating factor when considering microvascular decompression to treat the trigeminal neuralgia. Collapse of the cyst at surgery may destabilize the posterior fossa and further deform the trigeminal nerve. We suggest that RF-TR, which is minimally invasive and reliable, may be preferable.

Adult↗

PubMed2005

Management of a hemidystonic patient with thalamotomy, campotomy and cervical dorsal root entry zone operation.

Several medical and surgical procedures have been presented for treatment of dystonia. Thalamotomy, pallidotomy, and campotomy are some of the surgical choices. This study presents a patient with dystonia who underwent a cervical dorsal root entry zone (DREZ) operation after thalamotomy and campotomy. A 23-year-old man who was resistant to medical treatment presented with left hemidystonia. Thalamotomy and campotomy were performed. The patient remarkably benefited from the procedure but dystonic complaints in his left arm continued. A cervical DREZ operation was performed 5 years after the first operation and the dystonic complaints decreased after the surgery. This article presents a new aspect for the treatment of dystonia. Based on the outcomes of the treatment, DREZ operation may be suggested as an alternative surgical treatment for patients with segmental dystonia located in the extremities.

Adult↗

PubMed2004

The surgical treatment of chronic pain: destructive therapies in the spinal cord.

Stereotactic pain surgery is accepted as a group of procedures. These are usually highly sophisticated and technically risky procedures. In practice, the most important part of this discipline is not the technical abilities of the surgeon, but selection of the most appropriate patients for the available procedures. We must remember that we are performing all these procedures with the cooperation of patients. The energy that is used for lesioning can be stopped when desired. The target we want to approach can be definitely and anatomically visualized and demonstrated, and the function of the target is evaluated with neurophysiologic impedance techniques and stimulation. Thus, if we are able to understand the language of the central nervous system, these are available, effective, and safe procedures in neurosurgical practice. We must remember that if intractable pain can be controlled by minimally invasive destructive techniques, the patients will not be dependent on implantable systems, drugs,and medical units. This independent lifestyle is a critical goal central to quality of life for patients having intractable pain.

Afferent Pathways↗

PubMed2004

Expression of TAP73 and DeltaNP73 in malignant gliomas.

The p73 gene is able to encode transcriptionaly active TAp73, as well as a dominant-negatively acting DeltaNp73 transcript isoforms. We studied differential expression of these forms in normal brain as well as glial tumors, by semiquantitative RT-PCR. The expression of p73 was low or undetectable in normal brain tissues. Most of the tumors and non-tumor brain tissues also lacked significant expression of p73 in patients with low-grade astrocytomas. In contrast, most high-grade glial tumors displayed strong up-regulation of TAp73, whereas only a few displayed DeltaNp73 expression. These aberrations may reflect the inactivation of retinoblastoma pathway in these tumors which result in the activation of E2F transcription factors, since TAp73 is a known target of E2F1 gene. The study of TAp73 expression in brain tumors may serve as a means to evaluate the retinoblastoma pathway-dependent tumor progression.

Brain↗

PubMed2003

Microelectrodes.

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Electric Stimulation Therapy↗