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Biomedical subjects

Yibin Zheng

Publications and source records attributed to Yibin Zheng.

2 recordsLinked to original sources

Novel transmit aperture for very large depth of focus in medical ultrasound B-scan.

Obtaining high quality ultrasound images at high frame rates has great medical importance, especially in applications in which tissue motion is significant (e.g., the beating heart). Dynamic focus and dynamic aperture can improve image quality significantly, and they have been implemented on the receive beam in state-of-the-art medical ultrasound systems. However, implementing dynamic focus and dynamic aperture on the transmit beam compromises frame rate. We introduce a novel sinc squared-argument transmit aperture that is obtained by coherently integrating the quadratic phase change over a continuum of focal points. Thus uniform sensitivity and uniform point spread function can be achieved over a very large depth without reducing the frame rate. Numerical simulations validate our theoretical analysis and demonstrate significant promises of the new technique.

Computer-Aided Design↗

Laser-induced fluorescence detection on multichannel electrophoretic microchips using microprocessor-embedded acousto-optic laser beam scanning.

An improved method for fast scanning and fluorescence detection on multimicrochannel microchips is presented using acousto-optic-deflection-driven laser-beam scanning. A microprocessor embedded subsystem used in conjunction with LabView program as the human-machine interface for control of laser-beam scanning and data preprocessing allowed faster scanning and addressing speeds to be attained and improved attenuation calibration and the data sampling speed. This system allows for flexible, high-resolution fluorescence detection for multimicrochannel electrophoresis in a manner that can be applied to a number of high-throughput analysis applications. Incorporating an F-theta focusing lens into the optical set-up allowed for a laser spot as small as 10 microm to accurately be addressed to the center of microchannels. With this spot size, it will be possible to further increase the channel density in the scanning range without encountering crosstalk. Using a six-channel microchip (four separation channels, two alignment channels), the simultaneous separation and fluorescence detection of amino acids and DNA digest samples in four channels is illustrated. User-friendly interpretation of the separation data is facilitated not only by a peak alignment/normalization routine developed within the software, but also through improved signal-to-noise ratios obtained through exploitation of signal processing.

Acoustics↗