Biomedical subjects

Yasutomi Kinosada

Publications and source records attributed to Yasutomi Kinosada.

8 recordsLinked to original sources

PubMed2005

Equivalent cross-relaxation rate imaging for sentinel lymph node biopsy in breast carcinoma.

Sentinel lymph node biopsy (SLNB) is an important technique for detecting axillary lymph node metastasis in breast carcinoma patients. However, false-negative results are a problem. Equivalent cross-relaxation rate (ECR) imaging (ECRI) is a measurement method that can be used to quantitatively evaluate a change in the structural organization of lymph nodes by magnetic resonance imaging (MRI). We performed axillary ECRI in an attempt to decrease the false-negative results of SLNB. Regions without metastases showed a higher ECR value. On the other hand, regions with metastases showed a lower ECR value. The ECR images were compared with macroscopic histology images in which the presence or absence of axillary lymph node metastasis could be evaluated. ECRI is a potentially useful method for evaluating the efficacy of SLNB.

Adult↗

PubMed2005

[On the role of clinical information system in near future].

Information and communication technology has been growing up so rapidly. But, we should not forget that what we call "information" implies "digital in format". The digitalized information is essential for transmitting, sharing by many people in real time, processing, fusing, and so on. Creating three-dimensional CGs from a set of large volume image data or doing curved reformation can be performed in a blink of an eye. Now, it is also easy for an operator to get to know the stiffness of the organ through a manipulator by using the power-feedback technology. Organic integration of a variety of medical information provide a new virtual reality world which is valuable space such as a collaboration work place in a operation field. This is one of a model of the information assisted operation system. Therefore, the reader can easily understand that once he get the digitalized information, all that is left is not the technique but the "sensibility". This article is designed for readers to get to know above-mentioned technical aspect and its applicable system. Finally, I believe that technologies regarding the medical information system could contribute to some activities in the surgery in near future.

Cooperative Behavior↗

PubMed2004

Equivalent cross-relaxation rate imaging of breast cancer.

PURPOSE: To determine whether equivalent cross-relaxation rate (ECR) imaging is a feasible method for demonstrating breast cancer. MATERIALS AND METHODS: Fifteen breast cancer patients underwent both ECR imaging, with off-resonance saturation pulses at frequency offsets of 7 and 19 ppm (ECR-7 and ECR-19, respectively) from water resonance, and gadolinium (Gd)-enhanced dynamic magnetic resonance imaging (MRI) of the breast. The mean tumor size was 26.5 mm. The tumor outlines defined by their shape and margin on ECR-7 images were compared with the subtraction images produced by the dynamic study, and the distribution of hyperintensity areas and their shapes on ECR-19 images were assessed. All patients had surgery and pathological findings were compared to ECR images. RESULTS: The tumor outline of 13/15 (87%) tumors on ECR-7 images was nearly identical to that on subtraction images; ECR-19 images demonstrated the location and degree of fibrosis. The tumor outline of the other two tumors was less clear on ECR-7 images, and internal hyperintensity on ECR-19 images reflected intratumoral fibrotic foci. ECR-7 and -19 imaging findings allowed identification of four distinct tumor types that reflected the tumor growth patterns and their internal structures associated with fibrosis. CONCLUSION: ECR imaging is a feasible imaging technique for demonstrating breast cancer.

Adult↗

PubMed2003

Equivalent cross relaxation rate image for decreasing a false negative case of sentinel lymph node biopsy.

In the breast carcinamas, sentinel lymph node biopsy (SLNB) attracts attention as technique to be settled by axillary lymph node metastasis, but existence of a false negative case is a problem. Equivalent cross relaxation rate image (ECRI) is the measurement method that we can evaluate a change of organization structure quantitatively by magnetic resonance imaging. We executed axillary ECRI as a purpose with decreasing a false negative case of SLNB. ECRI related to a macroscopic image, and it was possible to evaluate yes or no of axillary lymph node metastasis. ECRI is the useful method to evaluate adaptability of SLNB.

Axilla↗

PubMed2003

[MRI tagging].

Explore the source record for details and available documents.

Animals↗

PubMed2002

Economic impact of real-time teleradiology in thoracic CT examinations.

Conventional teleradiology is a useful tool, but sometimes we have found it to be an insufficient means of investigation because the radiological specialists cannot indicate the imaging protocol during the investigation. The purpose of our study was to evaluate the efficacy of real-time teleradiology, which will improve the quality of medical management. Ten radiologists evaluated thoracic CT scans of 50 patients transmitted through teleradiology retrospectively. We evaluated whether or not the contrast enhancement study was performed effectively on the basis of the clinical data and after interpretation of the pre-contrast scans. The clinical data showed that 47.6% of the CT contrast enhancement examinations were not necessary. After interpretation of the pre-contrast CT scans, 66.6% of the contrast-enhanced scans were considered unnecessary. Real-time teleradiology will improve the quality of medical management providing the virtual presence of radiologists, and will save medical costs.

Contrast Media↗

PubMed2002

Magnetization transfer ratios of musculoskeletal tumors.

The magnetization transfer method is a relatively new technique that creates contrast by the exchange of magnetization protons associated with macromolecules and bulk water protons through cross-relaxation or chemical exchange. We measured the magnetization transfer ratio (MTR) and compared it with the DNA index to determine whether MTR can serve as an indicator of malignancy in musculoskeletal tumors. The DNA index correlated with MTR in such musculoskeletal tumors ( P < 0.05). This suggests that MTR can be used as a parameter to quantitatively indicate malignancy.

Bone Neoplasms↗

PubMed2002

Equivalent cross-relaxation rate imaging in the synthetic copolymer gels and invasive ductal carcinomas of the breast.

The values of equivalent cross-relaxation rate (ECR) correlated well with [i] water conditions in various copolymer gels and [ii] nature of malignant cells with regard to nuclear dysplasia and mitotic potential in breast carcinomas. The synthetic copolymer gels composed of any two or three monomers among 2-hydroxyethyl methacrylate (HEMA), glycidyl methacrylate (GMA), N-vinyl-2-pyrrolidinone (N-VP), methyl methacrylate (MMA) and benzyl methacrylate (BMA). The ECR measurement was performed by using an off-resonance saturation pulse under conventional field-echo imaging at frequency within +/- 75 ppm apart from the water resonance frequency. The ECR values were readily to determine and non-time consuming parameter for cross relaxation rate. The ECR values at the frequency offset by 7-ppm (ECR-7) were divided the sample gels two classes, which must correspond to hydrophilic or hydrophobic ones. The sensitivity in the gels was nearly equivalent to the cross-relaxation rate itself. In the breast carcinomas, the ECR-7 correlates with the nature of malignant cells with regard to nuclear dysplasia and mitotic potential. The ECR-7 is better or more accurate than the STR-7 because the SDNRs between carcinoma and glandular tissue increased by approximately 50% on the ECR-7 compared with the STR-7. Thus the ECR values could be a new parameter for malignancy and cell proliferative activity of the breast carcinomas with non-invasive modalities by magnetic resonance imaging.

Adult↗