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Biomedical subjects

Y Zhou

Publications and source records attributed to Y Zhou.

At least 469 records · Page 26Linked to original sources
PubMed1999

[Antihypertensive study of xingnao qingxuan recipe].

OBJECTIVE: To observe the effect of decreasing blood pressure of Xingnao Qingxuan Casuples. METHOD: The blood pressure in normal and anesthetised cats was examined with direct method, the blood pressure in the conscious SHR was obtained by indirect method. RESULTS: Duodenuos administration(id) of XQC of 2.8 g/kg produced a decrease of blood pressure in normal cats; XQC of 1.4, 2.8 and 5.6 g/kg once a day for 14 days produced a dose-dependent reduction of blood pressure in SHR, 3-4 days after administration the blood pressure returned to the level before but the change was not significant. With gastric administration of XQC of 2.8 and 5.6 g/kg for 3 times, the incubation period of eyeball tremor induced by chloroform by dropping into the ear was prolonged by 14.4% and 13.0%, and the keeping time shortened by about 33.3% and 23.3% respectively. Brain basic arterial spasm induced by KCl or 5-HT in dog was relaxed obviously by XQC in vitro experiment. CONCLUSION: XQC has the effect of reducing blood pressure resisting dizziness, which is related to the diastole of brain blood vessel.

Animals↗
PubMed1999

[Survey on traditional medicinal resources of Uncaria distributed in China].

OBJECTIVE: To make clear the botanical origin of medicinal Uncaria distributed in China and the situation of its use in folk medicines. METHODS: Collecting data and making on-the-spot investigation. RESULTS: There are thirteen medicinal plants which belong to Uncaria genus, and ten of them are commercially available. A clear idea was obtained of their geographical distribution, distribution features and practical experiences in folk application. CONCLUSION: This investigation is helpful in further researching and exploring the resources of Uncaria for medical use, as well as provides a scientific basis for production, management and safe use of crude drugs.

China↗
PubMed1999

[Effect of decompression or transplantation of the facial nerve on serious advanced facial paralysis].

OBJECTIVE: To investigate operative effect on serious advanced facial paralysis. METHOD: 28 cases (28 sides) with serious facial paralysis underwent decompression or transplantation of facial nerve. RESULT: After following up 0.5-2 years postoperatively, the total, most or partial and no recovery were 14 cases (50%), 12 cases (42%) and 2 cases (7.1%) respectively. CONCLUSION: The operation performed as early as possible can be an effective procedure for correcting serious advanced facial paralysis if conservative treatment could be confirmed to be helpless.

Adolescent↗
PubMed1999

[The expression of suppressor gene p16, p21 and p53 in nasopharyngeal carcinoma].

OBJECTIVE: To evaluate the roles of p16, p21 and p53 protein expression in nasopharyngeal carcinoma (NPC). METHOD: The SP immunohistochemical method was used to detect the expression of p16, p21 and p53 protein in 116 cases of NPC and 15 cases of non-tumour nasopharyngeal tissue. RESULT: 1. The positive expression rates of p16, p21 and p53 protein were 64.7%, 45.7% and 90.5% in NPC respectively. There were significant differences between NPC and non-tumour group (P < 0.05). 2. The expressive rate of p16 protein was 70.6% in non-keratinizing type, 44.8% in undifferentiated type (P < 0.05). 3. The positive expression of p21 was correlated with the expression of p16 and p53. CONCLUSION: Low expressions of p16 and p21 protein may play an important role in carcinogenesis of NPC, and that of p16 has some relation to cell differentiation of NPC. p16 protein may co-operate with p21 protein in development of NPC. p21 protein is probably not produced by stimulating wild-type p53 protein.

Adult↗
PubMed1999

[Bilateral large vestibular aqueduct syndrome (7 cases reported)].

OBJECTIVE: To explore the CT features and the auditory threshold in patients with bilateral large vestibular aqueduct syndrome. METHOD: The diameter of vestibular aqueduct in CT and the auditory threshold in each ears of seven patients were measured. RESULT: Asymmetry of the enlarged vestibular aqueduct was found in all patients of whom the side the vestibular aqueduct enlarged was found having a greater hearing loss than the other side in the same patient (paried t-test; P < 0.05). CONCLUSION: The measurement of vestibular aqueduct may be useful in determining the prognosis of patients with large vestibular aqueduct syndrome.

Adolescent↗
PubMed1999

[Determination of active components in caoyiguang wettable powder by reversed-phase high performance liquid chromatography].

The Caoyiguang wettable powder is composed of two active components, synergists and other additives. The active components, bensulfuron methyl (Londax) and metolachlor (Dual), in 15.5% Caoyiguang wettable powder were determined by reversed phase high performance liquid chromatographic method simultaneously. The ZORBAX SB-C18 column (4.6 mm i.d. x 250 mm, 5 microns) and acidic mixture of methanol and water as mobile phase were used. The results showed that the recoveries were 98.1%-102.6%, and the coefficients of variation were 0.4%-0.8%. The method has been used to determine samples with satisfactory results.

English Abstract↗
PubMed1999

[Computer-assisted identification of fundus lesions and a study of its reliability].

This study aimed at the use of computer for identifying fundus lesions quickly and reliably. We adopted the 'area filling' method to program in Visula C++, used the program to mesure the retina cotton-wool patches in diabetics (15 eyes), and then calculated the coefficient of variation to evaluate its reproducibility. The results showed that the coefficient of variation of the measurements ranged from 3.22% to 9.46%. In conclusion, this method is convient, quick and reliable.

Algorithms↗
PubMed1999

[Blood pressure examination using oscillometric method].

The effect of pressure sensor, filter and blood pressure algorithm upon oscillometric method is discussed in this paper. The design principle and parameters configuration used in portable blood pressure HOLTER are presented.

Algorithms↗
PubMed1999

[Preliminary study of a new concept for left ventricular assistance dynamic aortic valve].

Dynamic aortic valve, a novel design for left ventricular assistance is proposed. An impeller similar to the airscrew is placed in the position of aortic valve. The impeller is held by a pair of bearings in the center of a cylindrical supporting cage which is located in the lumen of the aorta ascendens. The supporting cage is attached to the valve annulus by a sewing ring of textile cuff around the outside of the cage. A rotor is fitted into the cage and connected to the impeller with a common shaft. The cage supports the aortic wall, thus prevents the rotor from founching the wall and allows the rotor to rotate freely. A stator, functioning as that of the electric motor, is located outside the aortic wall. When actuated, the magnetic field generated by the stator would drive the rotor to turning, and the axial flow of blood from ventricular to the aorta would be produced, resulting in the reduction of the ventricular load. We studied this concept in a simulating model. The result suggests that this design be reasonable. Further exploration of this concept is justified.

Heart Valve Prosthesis↗
PubMed1999

[Immune responses in mice vaccinated with recombinant plasmid pcDNA3 containing ROP1 gene from Toxoplasma gondii].

AIM: To observe the immune responses in BALB/c mice vaccinated with the constructed recombinant plasmid, pcDNA3, containing ROP1 gene from Toxoplasma gondii. METHODS: The plasmid DNA obtained by alkaline lysis were injected into the left leg of each mouse at a dosage of 100 micrograms. A booster vaccine was given using the same dosage two weeks later. Control groups were injected with the pcDNA3 blank plasmid and normal saline, respectively. 30, 50 and 70 days after the booster injection, the proliferation activity of T lymphocytes and the NK cell activity were determined using MTT assay, the number of CD4+/CD8+ T cells with indirect immunofluorescence assay and the titer of IgG antibody by ELISA. RESULTS: The spleens of mice enlarged obviously after immunization with pcDNA3-ROP1. The activity of proliferation of spleen T lymphocytes was higher in the immunization group than in the control groups; The NK cell activity in the immunization group was higher than those of control ones. The number of CD4+ T cells showed no obvious increase but CD8+ T cells obviously increased. The titer of IgG antibody in the immunization group showed no significant increase until 90 days later. CONCLUSION: Vaccination of mice with the recombinant plasmid, pcDNA3-ROP1, could elicit cellular and humoral immune response in mice.

Animals↗
PubMed1999

[The preliminary study of amniotic membrane on TGF-beta 1 expression after photorefractive keratectomy].

OBJECTIVE: To investigate the effect of amniotic membrane on TGF-beta 1 expression after photorefractive keratectomy(PRK). METHODS: PRK was performed bilaterally on 6 New Zealand white rabbits. One eye was randomly tranplanted with preserved human amniotic membrane, and the other eye served as the control. The expression of TGF-beta 1 mRNA was detected with in situ hybridization at the 4th weeks after PRK. RESULTS: TGF-beta 1 mRNA expression was present in the corneal epithelium and stroma at the 4th weeks after PRK. The cornea in amniotic membrane transplanted group had also TGF-beta 1 mRNA expression, and the expression extent was less than that in control group (P < 0.05). CONCLUSION: Amniotic membrane can reduce the expression of TGF-beta 1 mRNA in cornea after PRK.

Amnion↗
PubMed1999

[The research of distributed HRV analysis system based on DCOM].

This article introduces the meaning of Distributed Component Object Model(DCOM), which used network communication protocol to replace the local process communication to reach the aim of Distributed Computing, then it discusses the significance of HRV analysis, and finally it presents the system we developed.

Computer Communication Networks↗
PubMed1999

[Detection of TT virus DNA in peripheral blood mononuclear cells in patients with chronic hepatitis B and hepatocellular carcinoma using PCR and in situ hybridization].

OBJECTIVE: To determine whether the TTV infection occurs in peripheral blood mononuclear cells (PBMCs) of patients with chronic hepatitis B (of medium degree) and in HBsAg positive hepatocellular carcinoma (HCC). METHODS: TTV DNA in PBMCs was detected by nested-polymerase chain reaction(PCR) and in situ hybridization (ISH). RESULTS: 7 of 26 cases of chronic hepatitis B were positive for TTV DNA by nested-PCR with a positive rate of 26.9% that was significantly higher than that of normal control(chi 2 = 14.3, P < 0.001); 4 of 21 HBsAg positive cases were positive for TTV DNA by nested-PCR with a positive rate of 19.0%, also significantly higher than that of normal control(chi 2 = 4.86, P < 0.05). 4 of 7 TTV positive patients with chronic hepatitis B tested by nested-PCR were positive for TTV DNA by ISH in PBMC cytoplasm, with a positive rate of 57.1%. CONCLUSION: (1) A higher incidence of TTV DNA in PBMCs of patients with chronic hepatitis B and in HBsAg positive HCC was identified by nested-PCR and ISH; (2) TTV DNA was in the cytoplasm of PBMCs in patients with chronic hepatitis B.

Adult↗
PubMed1999

[The protective effects of ciliary neurotrophic factor on inner ear damage induced by intensive impulse noise].

OBJECTIVE: To evaluate the feasibility of using ciliary neurotrophic factor(CNTF) to treat intensive impulse noise-induced inner ear damage. METHODS: The guinea pigs were given either CNTF (CNTF group) or 0.9% sodium chloride (NS group) for 3 weeks after impulse noise exposure. The animals receiving neither medicine nor noise served as a control group. ABR threshold shifts, the cochlear AchE staining as well as the hair cell and spiral ganglion cell counting were carried out in three groups of animals. RESULTS: The numbers of damaged hair cells and spiral ganglion cells in the CNTF group was less than that in the NS group. AchE activity alteration was also less severe in the CNTF group. Similar to the morphological results, changes in the auditory function, represented by the ABR threshold shifts, was less in the CNTF group. CONCLUSION: CNTF can protect cochlear hair cells and spiral ganglion cells against intensive impulse noise exposure by decreasing degeneration and necrosis of the hair cells in some extent and expedite hearing recovery.

Animals↗
PubMed1999

[The study on the structure of 5,10,15,20-tetra-(4-hexadecylpyridiniumyl)porphyrin LB films].

The film-forming properties of 5,10,15,20-tetra-(4-hexadecylpyridiniumyl)porphyrin bromide (TC16PyP) on the air/water interface were studied. LB films of the amphiphilic porphyrin were prepared on the glass, quartz and SnO2 OTE substrates. The morphology and structure of TC16PyP LB films were characterized by scanning tunnelling microscope, UV-Vis absorption spectra, fluorescence spectra and low-angle X-ray diffraction. The experimental results indicated that the amphiphilic porphyrin TC16PyP has good film-forming properties on the air/water interface, its LB films are stable, in TC16PyP monolayer or LB films the long alkyl chains are not straight and the porphyrin macroring is lying nearly parallel to the substrate surface.

Molecular Structure↗