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Biomedical subjects

Y Zheng

Publications and source records attributed to Y Zheng.

At least 109 records · Page 6Linked to original sources
PubMed2001

[Effects of conjugated linoleic acid on the metastasis of mouse melanoma B16-MB].

In order to explore the effects of conjugated linoleic acid on tumor metastasis, the proliferation, gap junction intercellular communication (GJIC), adhesion to extracellular matrix, and metastasis cascades of tumor cells were imitated in cell culture. The results showed that 100 and 200 mumol/L conjugated linoleic acid could inhibit the proliferation and the adhesion of tumor cells to extracellular matrix, and could recover its gap junction intercellulor communication.

Animals↗
PubMed2001

[Research advances of multidimensional reconstruction of ultrasonic heart images].

The methods, present research situation, existing problems, and application foreground of multidimensional reconstruction of ultrasonic heart images are discussed in the present paper. According to the procedure of multidimensional reconstruction of ultrasonic heart images, the discussions are presented in respect to image acquisition, processing, and display. Based on the present situation and existing problems, the future development and application foreground are proposed.

Echocardiography, Three-Dimensional↗
PubMed2001

[Review of filtering algorithms for medical ultrasonic images].

Several kinds of filters for medical ultrasonic images, such as multidimensional filter, adaptive weighted filter (for example, adaptive weighted median filter), adaptive window selecting filter (for example, homogeneous region growing mean filter and adaptive speckle suppression filter) and two-step filter, are introduced. The existing problems and the progress trend are also discussed. Some application instances for medical ultrasonic images of the filters discussed and the performance of the filters presented are based on the present authors' practice.

Algorithms↗
PubMed2001

[Relationship between delta-aminolevulinic acid dehydratase gene polymorphism and blood levels of lead and zinc protoporphyrin in children exposed to lead].

OBJECTIVE: To explore the associations of polymorphism of delta-aminolevulinic acid dehydratase (ALAD) gene with blood levels of lead and zinc protoporphyrin (ZPP). METHODS: Blood samples were collected from 370 children exposed to a higher level environmental lead and their blood levels of lead and ZPP, and ALAD genotype were examined. Exposure to lead condition, such as parents' lead exposure and sites of lead source around their residence, and age and sex were matched in ALAD1-1 and ALAD1-2/2-2 subgroups. RESULTS: Blood lead level was higher in the ALAD1-2/2-2 subgroup than that in the ALAD1-1 children [(2.621 +/- 0.561) mumol/L vs (2.360 +/- 0.596) mumol/L, P = 0.04)]. Blood ZPP level was also higher in with ALAD1-2/2-2 subgroup than that in the ALAD1-1 genotype [(13.07 +/- 9.38) mumol/L vs (9.90 +/- 6.30) mumol/L), P = 0.02)]. CONCLUSION: The results suggest that the ALAD1-2/2-2 genotype may influence the body burden and blood toxicity of lead in high lead exposed children.

Child↗
PubMed2001

[Auto-detection of contour in echocardiographic images based on active contour model].

Contour detection is one of the most difficult problems in the multi-dimensional reconstruction of echocardiographic images. A method based on active contour model is presented in the present paper to solve this problem. First, according to the characteristic of the ultrasonic medical images, an adaptive weighted median filter is used to suppress speckle noise and an adaptive threshold value is selected to get binary image. Then, mathematical morphological treatment is utilized to get the initial contour. At last, active contour model is employed to revise the initial contour and get the accurate final contour. Experiments with real and interpolated ultrasonic images are presented. The results show the effectiveness of this method. This method has practical use in the multi-dimensional reconstruction of ultrasonic medical images.

Algorithms↗
PubMed2001

[Factors allowing continuous working of female nurses in the People's Republic of China--survey of 15 hospitals in 5 areas].

PURPOSE: Few investigations have been conducted on working, childcare and home education among female nurses (nurses) in the People's Republic of China (P.R. of China). The purpose of this study was to clarify the factors allowing continued working of female nurses. METHODS: The subjects were nurses from 15 hospitals in 3 provinces and 2 autonomous areas. They were surveyed by questionnaire regarding their childcare and home education. In was distributed by the Ministry of Health in the P.R. of China and the data were collected between February and April in 1996. RESULTS: A total of 4,284 (80.0%) questionnaires were collected. 1. About 60% of the nurses began working when they were 15 to 19 years old. The average length of service was 13.9 years. 2. Their professional position correlated directly with their years of service. 3. 4.3% of them had not continued working. 4. The nurses entrust their children to day-care institutions (61.2%) or grandparents (22.3%) during the daytime, and to the father (66.3%) or the grandparents (19.5%) during the night. 5. 17.6% of them have experienced being away from home for more than one month due to their job. 6. 66.8% of the nurses have experienced more than one month official trip, and had children under 14 years old at the time. They entrusted their children to day-care institutions (34.1%), to the father (29.2%) and grandparents (25.3%) during the official trip. CONCLUSIONS: In summary, most nurses are employed when they are young and go on working as nurses. It is possible for them to continue their work after marriage, childbirth, and while they are bringing up their children. The high rate of working woman, sufficient nursery schools and family cooperation in housework can be pointed out as main factors that enable them to continue their work.

Adolescent↗
PubMed2001

[Childcare and home education in families of female nurses in the People's Republic of China--survey of 15 hospitals in 5 areas].

PURPOSE: The purpose of this study was to investigate the actual conditions of childcare and home education among families of female nurses in the P. R. of China. METHODS: The subjects were nurses from 15 hospitals in 3 provinces and 2 autonomous areas. They were surveyed by questionnaire regarding their childcare and home education. It was distributed by the Ministry of Health in the P. R. of China and data were collected between February and April in 1996. RESULTS: A total of 4284 (80.0%) questionnaires were collected. 1. The age of the subjects was between 18 and 62 years old with a mean of 32.9 +/- 9.0 (SD) years 71.4% of them had husbands, whose ages were between 23 and 71 years old, the mean age being 38.3 +/- 8.4 (SD) years. The family types were 63.2% nuclear family and 33.7% extended family, with 3.1% being single. 65.1% of the subjects had children, whose mean number was 1.1 +/- 0.4 (SD). Firstborn children were 49.9% girls and 50.1% boys. 2. The most popular method of infant nutrition was breast-feeding, utilized by 60.1%. The highest rate (67.8%) was in the age group of 25 to 29 years old (P < 0.01). 3. The practice of "swaddling" (wrapping the child so as not to allow movement) was more common in the over 40 year old age group than the under 40 year old group (P < 0.01). Swaddling-practice showed significant differences by area. 4. The rates for children who helped with housework were 50.3% for girls and 46.7% for boys. 5. A number of children between 7 and 18 years old were studying English privately. 6. The greatest expectation of the subjects, for their children aged between 7 and 18 years old, was to study. CONCLUSIONS: 1. Infant nutrition showed significant differences between generations, and swaddling-practice differed with the generation and the area. 2. Although girls help their parents more than boys in Japan, boys and girls equally helped their parents in the P. R. of China. 3. Concerning the topics of private learning and parents expectations, the results were similar to those in Japan.

Adolescent↗
PubMed2001

[An evaluation on corrosion resistance of magnetic retainers].

OBJECTIVE: The present study was to explore the corrosion resistance of three kinds of magnetic retainers which named neodymium-iron-boron magnet and encapsulated in stainless steel. METHODS: Three kinds of magnetic retainers were exposed for 6 months to artificial saliva thermostated at 36.5 degrees C. This study included a electrochemical test as polarization curves and a chemical test as immersion test. RESULTS: In the electrochemical test, current density of the national keeper was 7.015 microA/cm2 and magnet was 0.119 microA/cm2. In the chemical test, corrosion rate of national keeper was 3.67 x 10(-5) mg/cm2.h and magnet was 1.77 x 10(-5) mg/cm2.h. The corrosion resistance of the national magnetic retainer had little difference with the imported ones. CONCLUSION: Transient exposure of stainless steel to artificial saliva environment is likely to significantly increase elemental release. It would affect the useful life span of magnets.

Corrosion↗
PubMed2001

[Eyelid reconstruction with a reversal flow axial preauricular island flap based on the supraorbital artery].

OBJECTIVE: In order to find an ideal flap to reconstruct the eyelid defect, we have explored the possibilities to reconstruct eyelid with a reversal flow axial preauricular island flap based on the supraorbital artery. METHODS: According to Chen's theory on "reversal flow axial flap", we designed and applied the reversal flow axial preauricular island flap based on the supraorbital artery, which could nourish the flap by anastomotic branches between the supraorbital artery and the frontal branch of the superficial temporal artery. RESULTS: We have successfully reconstructed 7 cases of eyelid defect with this method since 1997. The size of the flaps ranged from 4.0 cm x 2.4 cm to 2.0 cm x 1.8 cm and good result were revealed with 1-2 years follow up. CONCLUSIONS: The flap has a stable and reliable blood supplying. It is an ideal flap to reconstruct the eyelid defect for texture and color similarity of the eyelid and preauricular skin.

Adolescent↗
PubMed2001

[The diagnostic value and limitations of total serum bile acid determined enzymatically].

OBJECTIVE: To elucidate the diagnostic value of total serum bile acid. METHOD: Clinical data from 913 cases was statistically analyzed with SPSS for Windows and other statistical procedures reported previously. RESULTS: (1) The mean of TBA of healthy subjects was (4.0 +/- 3.2) micromol/L. The TBA level of liver disease group is significantly higher than other group(P < 0.01). (2) The mean of TBA of patients with acute hepatitis was (167.2 +/- 132.4) micromol/L, the highest value was 449.5 micromol/L, it was significantly higher than other groups. TBA was a sensitive mark reflecting acute hepatic injury. (3) The sensitivity of TBA in patients with cirrhosis was 85.8%, higher than routine liver function tests. TBA is a valuable mark reflecting collateral circulation. (4) The sensitivity of TBA in mild chronic hepatitis was only 30.5%, much lower than ALT and TBIL (P < 0.01). (4) There was a relationship between the level of TBA and the severity of patients' condition, but the value of TBA for evaluating the severity was not as good as TBIL. CONCLUSION: The specificity of TBA is quite high, the sensitivity is moderate, TBA is valuable for the diagnosis of liver disease, especially for acute hepatitis and cirrhosis, but it's sensitivity for mild chronic hepatitis is only 30.5%, it is not as good as TBIL for evaluating the condition of patients.

Acute Disease↗
PubMed2001

Segmentation of medical ultrasonic image using hybrid neural network.

Objective. To solve one of the most difficult problems in multi-dimensional reconstruction of medical ultrasonic images: image segmentation. Method. A new segmental method based on hybrid neural network was presented in this paper. The hybrid neural network comprised two phases. The first phase was Kohonens self-organization neural network, which was used to segment and label the image coarsely. The feature vectors of those pixels within a specified distance from the cluster centers were employed to train the second phase--a three-layer perception network using back-propagation (BP) technique. Then the trained BP network was used to label every pixel of the image. In the end, a post-processing stage was used to remove the small isolated points and smooth out the contours of the segmented image. Result. The segmented image had smooth continuous edges, few noises or speckles, and the contour of ventricle was clear and accurate. Conclusion. Our method could segment the ultrasonic images accurately and effectively, and had a lot of advantages compared to traditional methods. The unsupervised segmentation problems could be solved using supervised methods.

Cardiovascular Physiological Phenomena↗
PubMed2001

[The gene polymorphism of delta-aminolevulinate dehydratase (ALAD) in 530 cases of Chinese Han population].

OBJECTIVE: To explore the distribution of allele and genotype frequencies of delta-aminolevulinate dehydratase (ALAD) gene in Chinese Han population. METHODS: Blood specimens were collected from 530 unrelated Han individuals in the Central Plain of China. The ALAD genotype was determined using polymerase chain reaction-restriction fragment length polyporphism (PCR-RFLP) method. RESULTS: The frequencies of genotype in Chinese Han ethnic were 93.58% (496) for the ALAD(1 - 1) homozygote, 6.23% (33) for the ALAD(1 - 2) heterozygotes and 0.19% (1) for the ALAD(2 - 2) homozygote, respectively. The allele frequencies of the ALAD(1) and ALAD(2) were 0.967 and 0.033, respectively. CONCLUSION: The frequency of the ALAD(2) allele in Chinese Han population was similar to that in Asian populations and lower than that in Caucasian population.

Adolescent↗
PubMed2001

[Sequential intensified immunosuppressive therapy combining with hematopoietic growth factors in the treatment of severe aplastic anemia].

OBJECTIVE: To explore more effective regimen for reducing early mortality of severe aplastic anemia (SAA) and improving therapeutic effectiveness. METHODS: Antilymphocyte globulin/antithymocyte globulin (ALG/ATG) and cyclosporine A (CsA) (sequential intensified immunosuppressive therapy, SIIST), with or without hematopoietic growth factors (HGFs) were administered to 73 SAA patients in a prospective randomized clinical trial to test the effectiveness of the addition of HGFs for the patients. RESULTS: The response rate of SIIST with HGFs group was significantly higher than that of SIIST alone group (89.2% vs 63.9%), with lower rates of early infection (24.3% vs 55.3%) and mortality (4.0% vs 16.7%), shorter duration of cytopenia and blood transfusion dependence and faster recovery of bone marrow hematopoiesis. The addition of HGFs to SIIST was tolerated well in all patients. There was no difference in the treatment outcome of the two groups with GM-CSF plus Epo or G-CSF plus Epo. CONCLUSION: The use of HGFs in combination with SIIST could reduce early infection and mortality rates and, therefore, improve the response rates in SAA patients.

Adolescent↗
PubMed2001

[Study on the transformation from myelodysplastic syndromes into acute leukemias].

OBJECTIVE: To study the patterns of transformation from myelodysplastic syndromes (MDS) into acute leukemias (AL). METHODS: Leukemic transformation of MDS patients was dynamically followed up and the clinical manifestations, peripheral blood and bone marrow pictures, karyotypes, immunophenotypes, response to treatment and prognosis of post MDS acute leukemia (postMDS-AL) were observed. RESULTS: During the past eight year and seven months, 21 (13.91%) of 151 MDS patients progressed to overt leukemia with a median interval of 5 (1 - 21) months. There were no significant differences among the rates of leukemia from RA, RAEB and RAEB-t groups. The transformation was developed either gradually or rapidly. There were five parameters related to the leukemic transformation: under 40 years of age, pancytopenia, more than 0.15 blasts in bone marrow, at least two types of abnormal karyotype and combined chemotherapy. All of the 21 post MDS-AL were acute myeloid leukemia (AML); and most of them were M(2), M(4) and M(5). Two (9.52%) post MDS-AML developed extramedullary infiltration. Leukopenia was found in 47.62% of patients. Two third of the patients, whose bone marrows were generally hypercellular, showed neutropenias. After evolving into AML, 8 (47.06%) patients developed abnormal karyotypes. High expression of immature myeloid antigens, including CD(33) (49.83 +/- 24.50)%, CD(13) (36.38 +/- 33.84)%, monocytic antigen CD(14) (38.50 +/- 24.60)%, and stem cell marker CD(34) (34.67 +/- 30.59)% were found on bone marrow mononuclear cells of post MDS-AML cases. In some cases, lymphoid antigens, such as CD(5), CD(7), CD(9) and CD(19) were coexisted with myeloid antigens. A low complete remission rate (31.25%) and short survival duration with median survival of 6 (1 - 28) months were found in patients with post MDS-AML treated by induction therapy. CONCLUSION: MDS was at high risk of evolving into AML, either gradually or rapidly. Patients with post MDS-AML had specific biologic features and worse prognoses.

Acute Disease↗
PubMed2001

[Effect of iron deficiency anemia on the reproduction of female rats and the development of their offspring].

The effects of iron deficiency anemia(IDA) on the reproduction of female rats and the development of their offspring were studied. Four-week-old female Wistar rats were randomly divided into two groups. The rats in experimental group and control group were fed on low iron or normal diet respectively for 14 weeks, and then they were mated with normal adult male rats. The development and growth of the newborn, weanling and four-day-old offspring was observed and the trace element Fe, Zn, Cu, Mn and Se in serum were measured. IDA made notable impacts on the reproduction of female rats with small sized litters, less living fetal rats. The survival rate of female rats in the IDA group was less than that in control group. Hemoglobin and packed cell volume in blood were lower in IDA group than those in control group(P < 0.0001). The content of serum Fe and Cu in IDA group was also lower than that in control group. Iron deficiency might cause metabolism disorders of other trace element.

Anemia, Iron-Deficiency↗
PubMed2001

[The therapy of children with secretory otitis media by myringotomy with grommet insertion and the relevant management].

OBJECTIVE: To improve the diagnosis and treatment level of secretory otitis media (SOM) of children. METHOD: Clinical information of 80 children with SOM were collected and analysed. All of the 80 cases (144 ears) were treated by myringotomy with Grommet insertion. Among them 30 cases by adenotonsillectomy. 10 cases by palatoplasty. Secretions of 54 ears were carded out by bacterial culture. RESULT: 80 cases were followed up for 6 to 12 months. 120 ears of 144 were cured(83%), with hearing improved. The tympanograms and hearing threshold of pure tone were found to be normal. The Gram's positive and negative germs of bacterial culture were 20.7% (6/29 samples) and 24% (6/25 samples) respectively. CONCLUSION: Children with secretory otitis media should be treated as early as possible to improve the patients' hearing and develope their speech.

Child↗
PubMed2001

[Clinical analysis of 62 cases laryngeal papilloma in children].

OBJECTIVE: To investigate the clinical features of laryngeal papilloma in children. METHOD: In a group of 62 patients with laryngeal papilloma in children, the tumors of 28 patients were cut under the direct laryngoscope, 34 patients were treated with laryngeal micro-laser operation. RESULT: The post-operation followup ranged from 2 to 5 years, the cure rate of 2 years was 51.61%. CONCLUSION: The clinical features of this disease include rapid development, a large lesion, and it is often found in the infraglottic cavity. Furthermore, we believe that in order to eliminate the tumors more accurately and decrease recurrence, micro-laser surgery and the use of interferon is very necessary.

Adolescent↗