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Biomedical subjects

Y Zhao

Publications and source records attributed to Y Zhao.

At least 613 records · Page 34Linked to original sources
PubMed1998

[Changes of plasma nitric oxide and endothelin levels in normal pregnant women and pregnancy induced hypertension].

OBJECTIVE: To investigate the relationship of nitric oxide (NO), endothelin-1 (ET-1) levels and pregnancy induced hypertension (PIH). METHODS: 60 patients with PIH, 45 normal pregnant women and 15 normal non-pregnant women were studied. Plasma NO levels were determined. The stable metabolic product NO2-/NO3- of NO was letermined by Griess reaction. Plasms ET-1 levels were measured with radioimmunoassay. RESULTS: The NO2-/NO3- levels of the normal pregnancy group were significantly higher than those of the control group (P < 0.01), particularly in the second trimester of pregnancy. The NO2-/NO3- level of PIH was significantly lower in maternal plasma than that of the last trimester of normal pregnancy (P < 0.01) and nonpregnancy (P < 0.05), and it decreased with the disease development. In severe PIH the umbilical venous blood NO2-/NO3- level was significantly lower than that in the normal term pregnancy group (P < 0.01). The maternal plasma ET-1 level in PIH was significantly higher than that in the normal term pregnancy and control groups (P < 0.01). CONCLUSION: PIH might be related to decreasing synthesis and release of NO, and increasing ET-1 production.

Adult↗
PubMed1998

[Hemangioblastomas of the central nervous system with von Hippel-Lindau's disease].

OBJECTIVE: To study the clinical features of hemangioblastomas of the central nervous system (CNS) when they occucr as a manifestation of von Hippel-Lindau's disease (HLD). METHODS: 174 patients with hemanioblastomas of CNS were reviewed from 1982 to 1995. All patients were verified pathologically. RESULTS: Ten of the patients definitely had HLD. Four patients reported a positive family history. Other 5 patients had retinal angiomas. The following lesions were detected: renal cysts(2 patients), renal tumor (1). Five patients were suspicous. CONCLUSION: Hemangio-blastoma may arise in isolation or as a manifestation of von Hippel-Lindau's disease, and is often multiple in the latter. Enhanced MRI can decrease chances of negative diagnosis for tumor nodules. Microsurgery may be helpful to discover unclear lesions. Patients, especially those with HLD, should be subjected to follow-up and regular MRI examinations for a long time.

Adolescent↗
PubMed1998

[Studies on the in vivo induction of differentiation of the erythroleukemia cells by the antigen-pulsed dendritic cells modified with GM-CSF gene].

OBJECTIVE: To investigate the function and mechanism of dendritic cells in the immunotherapy for tumors. METHODS: C57BL/6 mice inoculated with erythroleukemia cells were used as models. Inhibition or induction of tumor cell differentiation was observed by fluorescence-activated cell sorting (FACS) and transmission electron microscopy. RESULTS: After pulsed with FBL-3 antigen, the GM-CSF gene transfected dendritic cells inhibited the proliferation of the tumor cells. The expression of CD14 was increased and the expressions of MHC-II, B7-1, B7-2 and VCAM-1 were also up-regulated. Erythroleukemia cells in different differentiating stages were observed in tumor tissues. Under transmission electron microscope, the volumes of FBL-3 cells were reduced, the amount of lysosome and hetero-chromatin became plentiful, the nucleocytoplasmic ratio was decreased, and apoptosis was revealed in erythroleukemia cells. The CD8+ cells were increased in peripheral blood and tumor tissues. CONCLUSION: The antigen-pulsed dendritic cells modified with GM-CSF gene could induce in vivo the erythroleukemia cells to differentiate into monocytes.

Adenoviruses, Human↗
PubMed1998

[Application of IHW2 purged bone marrow to autologous bone marrow transplantation in the treatment of acute myeloid leukemia].

OBJECTIVE: To observe the clinical effectiveness of IHW2 purged autologous bone marrow transplantation (ABMT) in the treatment of AML patients. METHODS: Large volume of bone marrow was purged in vitro by IHW2 and then reinfused to patients for ABMT. RESULTS: All of the three patients transplanted with IHW2 purged autologous bone marrow successfully reconstituted hemopoiesis. Two patients got continuous complete remission for 36+ and 34+ months, respectively. The karyotype of one of the two patient was 46,XY,del(16)(q22) before ABMT and changed to 46,XY in 2 months after transplantation. The third patient relapsed after ABMT 19 months. CONCLUSION: The preliminary study suggests that IHW2 may have certain purging effect on leukemic cells and is safe for clinical application.

Adult↗
PubMed1998

[Repeat operations for recurrent trigeminal neuralgia after microvascular decompression].

For the study of cause and treatment of recurrent trigeminal neuralgia, repeat operations were performed in 12 patients with recurrent trigeminal neuralgia after microvascular decompression. Among repeat operations, there was vascular loop recompression at trigeminal root in 10 patients, negative exploration in 2 patients. The pain relief was achieved after neurovascular redecompression or neurolysis in all patients. The patients had no recurrent pain during a follow-up from 6 months to 4 years. The causes of recurrent trigeminal neuralgia after microvascular decompression and the questions related to repeat operations were discussed.

Adult↗
PubMed1998

[Subjective and objective of evaluation of UPPP in the treatment of obstructive sleep apnea syndrome in short-term follow-up].

Uvulopalatopharyngoplasty (UPPP) has become a widely accepted method for treating obstructive sleep apnea syndrome (OSAS). The authors studied 52 OSAS patients treated with UPPP and assessed pre- and postoperative parameters including subjective clinical analysis and objective evaluation of computer test. 34(65.38%) OSAS patients felt satisfied of improving snoring sound 3-6 months later following UPPP. 46 patients reported an improvement in their symptoms of daytime somnolence and morning headache. 41 patients underwent follow-up sleep analysis computer (SAC) study; 19 of them (46.34%) had a reduction in AHI more than 50%; meeting our criteria for surgical success. All 41 patients had a significant reduction of total duration of apnea at sleep stage. The study suggests that the effectiveness of UPPP in treating OSAS is limited and subjective clinical symptoms following UPPP do not correlate with the objective finding of SAC; so it is important to stress the significance of follow-up study and necessity to further therapy.

Adult↗
PubMed1998

[Clinical study of physiological age in accordance with the integration of traditional Chinese and Western medicine].

OBJECTIVE: TCM and western geriatric medical principles were used to study the assessment of aging in mankind. METHODS: The authors studied and examined 387 healthy subjects ranging from 45 to 69 years of age. Its indices included 24 TCM senility syndromes, 5 western medical neurophysiological indices. Thereafter, regression analysis was used to deduce a TCM-WM aging formula. RESULTS: Data from all clinical subjects were processed using integrated TCM-WM, physiological age formula to determine the physiological ages (Y) and their corresponding calendar ages (y). The mean values of the age differential of zero, and a standard deviation of 2.29 years were calculated. From statistical view point, a 95 percentage is an acceptable normal value range. Also, as the objective of the aging assessment only used the higher end of the range. I.E., it is considered there is excessive aging when physiological age is higher than calendar age by 3.37 years. In the process of conducting regression analysis, the authors also discovered that LPO can increase TCM senility syndrome score, whereas CuZnSOD decrease it. CONCLUSIONS: The above clinical study showed that the regression analysis and age-related TCM indices can comprehensively reflect the natural process of aging in mankind. It also demonstrated the highly predictive nature of TCM senility syndrome score.

Aged↗
PubMed1998

[The change of salivary beta 2-microglobulin concentration in normal adults].

OBJECTIVE: To understand the influence of various physiological factors on the concentration of beta 2-microglobulin in saliva. METHODS: We measured salivary beta 2-microglobulin concentration in 200 normal adults, from 21 year-old to 70 year-old, by means of radioactive immunoassay method. RESULTS: We found, that there was no significant difference between males and females in salivary beta 2-m concentration, and salivary beta 2-m concentration was more significantly elevated in the adults above 50 year-old, compared with the adults from 21 year-old to 50 year-old. We also found, that there was no significant correlation between salivary beta 2-m concentration and serum beta 2-m concentration. CONCLUSIONS: Our results suggested, that beta 2-m in saliva may be produced in oral cavity and salivary glands, and measurement of salivary beta 2-m concentration may offer a valuable method to diagnose lymphocytic infiltration disease in oral cavity or salivary glands.

Adult↗
PubMed1998

[Distribution and drug-resistance of 345 strains gram-negative bacilli from hospitalized patients with lower respiratory tract infections diseases].

OBJECTIVE: To investigate the distribution and drug-resistance of gram-negative bacilli in respiratory ward. METHOD: (1) Drug-resistance was tested by Kirby-Bauer disk sensitivity method and MIC by agar doubling dilution. (2) beta-lactanase was tested by nitrocephin. (3) ESBLs was tested by E test. RESULT: (1) Among 345 strains gram-negative bacillus, klebsiella pneumoniae and pseudomonas aeruginoea was about 39.7%, 17.4%, respectively. (2) Drug-resistance rate of cefotaxime dropped from 42.9% (6 years ago) to 8.2%. (3) beta-lactamase positive rate of 345 strains bacilli was 54.5%. (4) ESBLs was negative. CONCLUSION: (1) Klebsiella pneumoniae and pseudomonas aerugries were the main pathogens in lower respiratory tract infection in hospital. (2) Although we didn't find the evidence of ESBLs, we should pay more attention to it in the future.

Bronchiectasis↗
PubMed1998

[Application of the sphygmogram in evaluation of pilots' cardiovascular function in resting condition].

With the purpose of exploring a new method for aerospace medical monitoring, a newly developed method--sphygmogram was used in 169 pilots. The results showed that these pilots could be divided into three types by the features of their resting sphygmogram. Among them, with respect to their cardiovascular function, 71 (about 42%) were "completely normal", 79 were "essentially normal", and 19 had some changes in cardiovascular function. It is considered that the status of cardiovascular function of the pilots can be distinguished with the newly developed method of sphygmogram. It suggests that it is important to make dynamic observations of pilots' cardiovascular function and strengthen the medical care for those who show certain changes in their cardiovascular function as revealed by the sphygmogram.

Adult↗
PubMed1998

[Analysis of human posture control under weightlessness].

Dynamic equations of human trunk and limbs in weightlessness were established, and the motions in 6 dimensions were resolved into 3 motions in 3 dimensions. The feasibility and operability of human posture control in weightlessness by using simple actions were described directly with analysis, calculation and dynamic simulation, and the training methods on the Earth were proposed.

Aerospace Medicine↗
PubMed1998

[Effects of heat, noise, and their combination on plasma atrial natriuretic peptides, cardiodilatin, endogenous digitalis like substance, angiotensin II and endothelin in rats].

Plasma contents of atrial natriuretic peptides (ANP), cardiodilatin (CDD), endogenous digitalis like substance (EDLS), angiotensin II (A II) and endothelin (ET) were determined in rats following exposure to high temperature, noise and a combination of the two. It was found that plasma content of ANP after heat exposure decreased significantly, CDD and A II content after heat or noise exposure increased obviously, ET content decreased significantly after exposure to combined factors. ANP and CDD have the same physiological function and changes. ANP, CDD and A II observed in the present study were considered to be compensatory responses. It is harmful if exposure to high temperature or noise lasts for a long time.

Angiotensin II↗
PubMed1998

[Clinical effect of tianma-cuzhi granules on senile vascular dementia].

OBJECTIVE: To assess the clinical efficacy of Tianma-cuzhi Granules (TMC) in treating senile vascular dementia(VaD) of the "sthenia of liver-yang" type. METHOD: TMC were given to thirty VaD patients three times a day of 0.5 g/bageach. The treatment course was one month and the patients finished two consecutive courses. RESULTS: TMC could markedly increase the mini-mental state examination (MMSE) and Hamilton depression scale(HDS) marks of VaD patients, and also contribute to improving certain indexes especially in abnormal cases. CONCLUSION: TMC have certain effects on senile VaD.

Aged↗
PubMed1998

[Studies on flavonoids from Fenugreek (Trigonella foenumgraecum L.)].

OBJECTIVE: To study the flavonoids in fenugreek (Trigonella foenumgraecum) produced in China. METHOD: The flavonoids were isolated with silica gel, polyamide and Sephadex LH-20 chromatography, and their structures were identified by physical, chemical properties and spectral analysis. RESULT: Five flavonoid compounds were isolated from fenugreek seeds and identified as vitexin, tricin, naringenin, quercetin and tricin-7-O-beta-D-glucopyranoside. CONCLUSION: Three flavonoids, tricin, naringenin and tricin-7-O-beta-D-glucopyranoside, were isolated from fenugreek as well as from the plants of Trigonella for the first time.

Apigenin↗
PubMed1998

[Effects of processing on toxicity and pharmacological action of flos Genkwa].

Daphne genkwa can not be taken unless the toxicity is removed. The study on the effect of processing on the toxicity and pharmacological action of Flos Genkwa has shown that the toxicity of vinegar-processed Flos Genkwa is lower than that of the rude drug, but the pharmacological action is better. Both genkwanin and its vinegar-processed imitation have antitussive and expectorant actions without marked difference in efficacy. Both yuanhuacine and its vinegar-processed imitation could cause contraction of the extracorporeal womb and the intestinal canal, and the efficacy is almost similar in the concentration of 1:10(-5)-10(-6). The gestational womb was observed more sensitive than the normal one.

Animals↗
PubMed1998

[Isolation and identification of triterpenoids from Rubus alceaefolius Poir].

Five triterpenoid compounds were isolated from Rubus alceaefollius. On the basis of the chemical and spectral analysis the compounds were identified as corosolic acid, tormentic acid, niga-inchigoside F1, trachelosperoside E-1 and suavissimoside R1, were obtained from the plant for the first time.

Drugs, Chinese Herbal↗
PubMed1998

[Determination of content of radix Paeoniae Rubar(Chishao)801 in rabbit's plasma by HPLC].

A HPLC method was used to determine the content of Radix Paeoniae Rubar (Chishao)801 in rabbit's plasma, using Nucleosil C18 column, methanol, water and glacial acetic acid (48:50:2) as mobile phase ethye 4-hydroxybenzoate as internal standard, and UV-detector(lambda max: 275 nm, AUFS: 0.02). The average recovery was 96.70%(C: 2.5 micrograms/ml) and 98.86%(C: 5 micrograms/ml) respectively. The lowest determination limit was 0.1 microgram/ml. The method is simple, accurate, sensitive and reliable.

Animals↗