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Biomedical subjects

Y Yoshimura

Publications and source records attributed to Y Yoshimura.

At least 613 records · Page 34Linked to original sources
PubMed1981

Tooth extractions and aortitis syndrome (Takayasu's disease).

Several problems in tooth extraction in patients with aortitis syndrome are described and the following points are stressed. (1) The extractions of teeth should be done at nonactive period of the disease. (2) Patients who reveal hyper- or impaired sensitivity of the carotid sinus should be positioned in the most relaxed way with no pressure and no stretch of the carotid sinus region. (3) Since no pulsation is present at any extremity in many patients, these patients should be carefully monitored during treatment. (4) Antibiotics before tooth extraction are necessary. (5) Tooth extractions should not alter an already unbalanced hemodynamic state to a more severe stage.

Adult↗
PubMed1981

Structural studies on thiocillins I, II and III (studies on antibiotics from the genus Bacillus XXIX).

Thiocillins I, II and III were compared with micrococcin P1 by analysis of acid hydrolyzates of the native and the reduced antibiotics as well as by means of 1H and 13CNMR spectroscopies. As a result of these studies, the differences of these antibiotics were clarified in their structural units, and the structures of thiocillins I, II and III were assigned on the basis of the proposed structure of micrococcin P1.

Anti-Bacterial Agents↗
PubMed1981

Water-soluble siomycin-A derivatives. Preparation, chemical structures and biological properties of half-esters of the peptide antibiotic.

The peptide antibiotic siomycin-A was transformed into half-esters with dicarboxylic acids with the intention of making siomycin-A soluble in water. Sodium salts of the half-esters were also prepared. Some of the salts showed antibacterial activities comparable to siomycin-A against Gram-positive bacteria in vitro and exhibited better therapeutic effects in infected mice than siomycin-A. The chemical structures of siomycin-A hemiadipate-II and -III were elucidated by comparing their 13C and 1H NMR spectra with those of siomycin-A. Their physicochemical properties are described.

Animals↗
PubMed1981

General pharmacological properties of UFT, a new type of anti-cancer agent consisting of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and uracil. I: Pharmacological analysis of the combined effect of FT and uracil.

The pharmacological properties of a new type of anti-cancer agent, 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) and uracil (U), in a molar ratio of 1:4, were investigated and compared with those of FT, 5-fluorouracil (5-FU) and uracil. UFT at doses larger than 874.8 (FT: 270.0) mg/kg p.o. produced slight central nervous depression in mice and rats, as demonstrated by prolongation of the thiopental anesthesia, analgesic activity in the acetic acid stretching test, an anticonvulsant effect on maximal electroshock convulsions and decrease in body temperature. In rabbits UFT at a dose of 291.6 (FT: 90.0) mg/kg p.o. produced an increase in the drowsy EEG pattern. UFT at high dose produced clonic convulsions in mice and rats and cardiac fibrillation in rabbits. UFT had slight cardiorespiratory effects in anesthetized rabbits and dogs and at a dose of 291.6 (FT: 90.0) mg/kg i.v. it increased the voltage of the T-wave in ECG in anesthetized dogs. At high doses UFT inhibited gastrointestinal transit in mice and it caused emesis in dogs. At doses larger than 291.6 (FT: 90.0) mg/kg p.o. it had a diuretic effect and at higher doses it slightly increased the blood glucose level in rats. FT at equal doses to UFT had the same effects as UFT and the effect of 5-FU was similar to that of UFT. The pharmacological activity of uracil was much less potent. It was concluded that the pharmacological effect of UFT was almost entirely due to FT, however, UFT had much less effect than FT in inducing clonic convulsions, increasing the voltage of the T-waves in ECG and inducing emesis, its depressant effect is probably due to its constituent uracil.

Analgesics↗
PubMed1981

[Studies on steroidogenesis of isolated granulosa cells and thecal tissue in tissue culture--with special reference to polycystic ovary syndrome (author's transl)].

The purpose of this study is to determine the steroidogenesis of polycystic ovary syndrome (PCO), through the comparison of steroidogenic potential between polycystic and normal ovarian cells harvested from follicles under 6 mm in diameter in vitro. 1) The granulosa cells were cultured by monolayer culture method, while the thecal tissue by explant culture method, at 37 degrees C using 5% CO2 in air for 18 days. 2) The cultured granulosa cells and thecal tissue grew successfully under 20% fetal calf serum with 80% medium 199. 3) The major product secreted by the cultured granulosa cells was progesterone, and the difference of steroidogenic potential between normal ovary and PCO was not significant. 4) The major products of isolated thecal tissue were delta 4-androstenedione and testosterone. Particularly, the cultured thecal tissue from PCO accumulated more androgens, in comparison with that from normal ovary. 5) The secretion of estradiol by the cultured granulosa cells was low in the absence of estrogen substrate and FSH. There was not appreciable difference in the capacity of granulosa cells from normal ovary and PCO to secrete estradiol. These results suggest that steroidogenic potential of isolated granulosa cells from PCO is comparable to that from normal ovary, whereas thecal tissue from PCO has more androgenic capacity than that from normal ovary.

Adult↗
PubMed1981

Quantitization of Ca spike frequency in a single sucrose gap and mechanical relaxation induced by Ca antagonists, isoproterenol and papaverine.

The suppression of the Ca spike frequency generated spontaneously in the guinea-pig taenia coli was quantitatively investigated using the single sucrose gap method in an attempt to correlate frequency with the relaxation induced by Ca antagonists, isoproterenol and papaverine. The intrinsic activity (a) of depleted Ca that gave the maximal response in the dose-spike frequency curve (DSfC) or dose-tension curve (DTC) was taken as unity. Verapamil and MnCl2: a of both the DSfC and DTC were 1.0. Papaverine: a of the DSfC was 0.5 in contrast to 1.0 in the case of the DTC, and the affinity of the DSfC was somewhat less than that of the DTC. Isoproterenol: a and affinity of the DSfC were considerably less than in the case of the DTC. These results indicate that (1) relaxation induced by the Ca antagonists we used clearly corresponded to the suppression of the Ca influx carrying the action potential, (2) the relaxation induced by isoproterenol was not due to direct suppression of Ca influx, and (3) papaverine and depleted Ca influenced Ca both directly and indirectly.U

Action Potentials↗