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Biomedical subjects

Y Yokomizo

Publications and source records attributed to Y Yokomizo.

At least 91 records · Page 5Linked to original sources
PubMed1987

Production and characterization of serovar-specific monoclonal antibodies to serovars 4, 8, and 9 of Mycobacterium intracellulare.

Serovar-specific monoclonal antibodies against Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum complex serovars 4, 8, and 9 were prepared. Nine, four, and one monoclonal antibodies, respectively, to the serovars were prepared by the usual cell fusion technique. All nine monoclonal antibodies to serovar 4 were monospecific for their homologous serovar and reacted with several native glycopeptidolipids (GPLs) and one major deacylated GPL from the homologous serovar. One of the four monoclonal antibodies to serovar 8 seemed to be monospecific for its homologous serovar, but the other cross-reacted with serovar 6 because serovar 6 organisms contain the same components as does the major deacylated GPL from serovar 8. One monoclonal antibody to serovar 9 was monospecific for its homologous serovar and reacted with one of the two major deacylated GPLs from this serovar. These antibody preparations proved useful for serovar identification.

Agglutination Tests↗
PubMed1985

Osteopathia striata with cranial sclerosis affecting three family members.

Skeletal surveys were performed on a 38-year-old Japanese mother, her son and daughter. The radiographs of both children showed characteristic features of osteopathia striata. However, in the mother, the skull, mandible, and lower extremities were homogeneously sclerotic with no evidence of a striated pattern of sclerosis in her skeleton. Additional features of striated sclerosis of the mandible in patients with osteopathia striata are discussed.

Adult↗
PubMed1984

Light and electron microscopic observations on granulomatous lesions in pigs dosed with Mycobacterium intracellulare.

The histology and ultrastructure of the granulomatous lesions were studied in 18 pigs dosed orally with Mycobacterium intracellulare serotype 8. The pigs were killed 2, 4, 6, 8 and 12 weeks after dosing. Histologically, initial granulomatous lesions were seen in the tonsils 6 and 8 weeks after dosing. Initial or more advanced granulomatous lesions were observed in the tonsils and lymph nodes (mandibular, jejunal, ileocolic and superficial inguinal) 12 weeks after dosing. The initial granulomatous lesions appeared as slight proliferations of epithelioid cells and multinucleated giant cells. Advanced granulomatous lesions were nodular proliferations of epithelioid cells and multinucleated giant cells (epithelioid-cell nodule). In more advanced granulomatous lesions, the epithelioid-cell nodules increased in size and showed caseation necrosis, calcification and fibrosis. Ultrastructural examination revealed that the epithelioid-cell nodules consisted of mononuclear cells, epithelioid cells and multinucleated giant cells. In the caseous foci of the epithelioid-cell nodules, an electron-dense amorphous material with collagen fibres was deposited in the intercellular spaces. Although a small number of acid-fast organisms were observed histologically, they could not be detected ultrastructurally. The histological and ultrastructural findings of the present cases are compared with those of pigs infected with M. avium and with human lesions of tuberculosis and sarcoidosis.

Animals↗
PubMed1983

Computed tomography of chronic eosinophilic pneumonia.

Chronic eosinophilic pneumonia was diagnosed in a 26-year-old woman, based on the characteristic peripherally distributed pulmonary infiltrates, eosinophilia, and relatively severe symptomatology. Her disease responded well to corticosteroid therapy. Computed tomography examination demonstrated mediastinal lymphadenopathy and peculiar, vertically oriented platelike infiltrates.

Adult↗
PubMed1983

Enzyme-linked immunosorbent assay for detection of bovine immunoglobulin G1 antibody to a protoplasmic antigen of Mycobacterium paratuberculosis.

An enzyme-linked immunosorbent assay (ELISA) was developed for the detection of antibodies to Mycobacterium paratuberculosis in the sera of cattle. This assay was designed to minimize the nonspecific ELISA reactions caused by immunoglobulin (Ig)M by measuring only IgG1 antibodies against a protoplasmic antigen from the organism. The ELISA detected IgG1 antibodies in the sera of 58% of cattle with positive fecal cultures for M paratuberculosis compared with detection of 45% of culture-positive animals with an immunodiffusion test. In addition to its sensitivity, the ELISA apparently is highly specific because only 4% of the sera from fecal culture-negative animals gave a false-positive result.

Animals↗