Biomedical subjects

Y Yazan

Publications and source records attributed to Y Yazan.

3 recordsLinked to original sources

PubMed1995

Rapid analysis of verapamil in plasma by reversed phase HPLC.

A modified and simple HPLC procedure has been developed for verapamil in plasma. Plasma samples have been vortex-mixed and centrifuged without any need of extraction. The analysis has been performed on a C20 reversed-phase column with fluorometric detection using 5,6-benzoquinoline as an internal standard. Standard curve has been found to be linear for concentrations from 30 to 1000 ng/ml (plasma) for verapamil and no potential source of interference was present. The method has the advantages of speed, small sample requirement and reproducibility. Applicability of the method has been demonstrated by a pharmacokinetic study in 7 rabbits which received a single dose of 0.25 mg verapamil hydrochloride by intravenous administration.

Animals↗

PubMed1993

Multiple emulsions.

The purpose of this review is to update the information on multiple emulsions known to be promising delivery systems for both pharmaceuticals and cosmetic materials. The possibility of encapsulating active substances within liquid membranes may lead to interesting opportunities in both fields. Thus the formulation, manufacturing, stabilization, analysis and potential application of multiple emulsions seems to be worth surveying, putting a special emphasis on cosmetic applications.

Chemistry, Pharmaceutical↗

PubMedDate not supplied

Preparation and in vitro dissolution of salbutamol sulphate microcapsules and tabletted microcapsules.

Salbutamol sulphate is a sympathomimetic amine having a rather short plasma half-life. Aiming to achieve sustained release of this drug through microencapsulation, the coacervation method with a 1:1 core-shell ratio was used. In vitro release rate experiments were performed on the microcapsules prepared using ethyl cellulose as the coating agent and compared to the results of intact drug, the tabletted microcapsules and a commercial tablet. The release rate of salbutamol sulphate could be controlled through microencapsulation. The time for the 50% release of the drug was 15 and 90 min for the tabletted microcapsules and microcapsules respectively. The specific surface area of the intact drug was 0.35 m2/cc while it reduced to 0.06 m2/cc after encapsulation.

Albuterol↗