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Biomedical subjects

Y Yano

Publications and source records attributed to Y Yano.

At least 433 records · Page 24Linked to original sources
PubMedDate not supplied

Group B streptococcal metastatic endophthalmitis in an elderly man without predisposing illness.

Our patient, an 83-year-old man, suddenly experienced acute lumbago and was prescribed bed rest. Later, pneumonia was diagnosed, even though he had no predisposing illness, and endophthalmitis developed in both eyes. Cultures of anterior chamber and vitreous specimens were positive for group B streptococcus. Treatment with systemic antibiotics, to which this bacteria is sensitive, was begun and his condition gradually improved. Nevertheless, the patient became blind in his right eye and the eye was enucleated. Histopathologic examination showed metastatic endophthalmitis with retinal detachment. Multiple microabscesses were found in the thickened choroid. We speculated that organisms disseminating from the microabscesses had caused the metastatic endophthalmitis.

Aged↗
PubMedDate not supplied

Substituent effects on electrophilicity of flavins: an experimental and semi-empirical molecular orbital study.

The reactivities of the triplet excited states of several flavins with different N(10)-phenyl substituents have been found to be very similar. There is a good correlation between semi-empirical molecular orbital calculations at the MINDO/AM1 level and observed redox potentials. However, the most interesting observation is that the substituent effects are very small; this suggests that the N(10)-phenyl substituents are nearly perpendicular to the plane of the main ring due to their steric interactions with the main isoalloxazine system. Computed calculations as well as the fact that similar absorption maxima are obtained for 3-methyl-10-phenylisoalloxazine and 3-methyl-10-methylisoalloxazine are in agreement with this prediction.

Flavins↗