Biomedical subjects

Y Y Ma

Publications and source records attributed to Y Y Ma.

26 records · Page 2Linked to original sources

PubMed1993

Reserpine impairs spatial working memory performance in monkeys: reversal by the alpha 2-adrenergic agonist clonidine.

Repeated daily treatment with the catecholamine-depleting agent, reserpine, dramatically reduced performance on the delayed response task, a test of spatial working memory that depends upon the integrity of the prefrontal cortex. Delayed response performance fell from an average of 27.2/30 trials correct before reserpine treatment to an average of 20.4/30 trials correct after repeated reserpine administration. Injection of the alpha 2-adrenergic agonist, clonidine (0.0001-0.05 mg/kg), to chronic reserpine-treated monkeys significantly restored performance on the delayed response task; performance after an optimal dose averaged 27.8/30 trials correct. Clonidine's beneficial effects on delayed response performance were longlasting; monkeys remained improved for more than 24 h after a single clonidine injection. The finding that clonidine is efficacious in reserpinized animals supports the hypothesis that alpha 2-adrenergic agonists improve cognitive function through actions at postsynaptic, alpha 2-adrenergic receptors on non-adrenergic cells. In contrast to the delayed response task, reserpine had little effect on performance of a visual discrimination task, a reference memory task which does not depend on the prefrontal cortex. These results emphasize the importance of postsynaptic, alpha 2-adrenergic mechanisms in the regulation of working memory.

Adrenergic alpha-Agonists↗

PubMed1992

[Effects of cytomegalovirus infection in pregnant women to fetuses: study with DNA-DNA hybridization method].

DNA of cytomegalovirus (CMV) was examined in 131 placentae and 28 umbilical blood specimens by DNA-DNA hybridization. The result revealed that CMV DNA was detected in 4 of 50 placentae from abnormal fetuses (31 fetal deaths, 19 fetal deformities). 77 placentae from normal fetuses showed negative results. One of 2 cord blood samples from fetal deformities showed CMV DNA positive. 25 umbilical blood samples from normal term newborns showed negative. 4 placentae and 1 cord blood sample from premature infants showed negative results. The results indicate that CMV may play a great role in fetal death and fetal deformity through the infected maternal-fetal circulation.

Cytomegalovirus↗

PubMed1988

Wounding properties of steel pellets with different velocities and quality on soft tissue of dogs.

The characteristics of the soft-tissue wounds of the hind legs of 155 dogs produced by stainless steel spheres with four different masses and at various impact velocities were observed. It was found that when the mass of the spheres was identical, the velocity became the main factor to determine the severity of the damage; when the mass of the spheres was different but their kinetic energy was similar, then a smaller but faster sphere produced more severe damage than a larger but slower one. Shallow but wide and severe wounds usually resulted. The rate of disability of extremities with such wounds was very high. These wounding properties of steel spheres have caused some new problems in the treatment of war injuries.

Animals↗

PubMed1988

The characteristics of the pressure waves generated in the soft target by impact and its contribution to indirect bone fractures.

When a high-velocity spherical fragment impacts a biological body, it will initiate strong pressure waves spreading throughout the body. A pressure wave, especially a shock wave with a steep front, generated by impact, may cause blood vessel injuries, viscera injuries, and indirect bone fractures. This paper reports research on pressure waves near the wound tracks, generated by spherical fragments, and calculates the zones of indirect bone fractures generated by pressure waves of impact.

Animals↗

PubMed1988

An analysis of the wounding factors of four different shapes of fragments.

The wounding characteristics to a biological target of four typical shapes of fragments (square, triangular, cylindrical, and spherical) with masses of less than 1 gram and velocities between 460 and 1,500 m/s are studied in this paper. The following conclusions about the effects of the wounding factors, such as energy transfer, velocity, mass, and shape of fragment are presented: 1) For given target characteristics, the important wounding factors of fragments are impact velocity, mass, and shape, and of these velocity is the most important. 2) Besides direct effects, the fragment velocity has great influence on far-reaching, indirect wounding effects. When velocity increases, it not only increases the size of direct wound, but also the rate of indirect bone fracture. 3) The rate of energy transfer is affected by fragment shape, and it is also a decreasing function of mass. 4) Under the same conditions there are differences in wounding effectiveness among the four fragment shapes, the triangular with a comparatively high wounding effectiveness, followed by the square, cylindrical, and spherical. The types of wound channels are also different, the cylindrical and spherical making a "through" type, the square and triangular making a "blind-tube" type.

Animals↗

PubMed1988

The wounding characteristics of spherical steel fragments in live tissues.

This paper reports the wounding effectiveness tests of four kinds of spherical steel fragments, striking against live tissues at various velocities. The most pronounced wound characteristic for the spherical fragments was that the entrances were larger than the exits; the higher the striking velocity, the larger the size of the wound. The skin near the entrance tended to be torn away when the striking velocity was above 1,200 m/s. As a general rule, most exits appeared to be circular with a diameter slightly bigger than that of the fragment. Shapes of the wound channels were conic in general. The channel volumes were proportional to the striking velocities of the fragments; in the case of two spheres having the same striking energy, the small one would produce larger volume of wound channel and amount of debrided tissues. The energy release rate for smaller fragments was higher than that for larger ones.

Animals↗

PubMed1988

An estimation of the physical characteristics of wounds inflicted by spherical fragments.

Based on test results of projecting four different types of spherical fragments, diameters of which were 3.175 mm, 4.763 mm, 5.56 mm, and 6.35 mm, respectively, into the biological soft tissues and the soap blocks used as simulants, an estimation of the physical characteristics of wounds inflicted by spherical fragments was established in this paper. With impact velocities in the range of 450-1,500 m/s, all four types of spherical fragments showed little variation in drag coefficients for each medium. Some specific wound characteristics such as amount of debrided tissue, volume of the wound channel, etc., can be predicted as functions of energy transfer for spherical fragments of less than 1 gram.

Animals↗

PubMed1988

[Traditional Chinese and Western medicine in the treatment of 27 patients with malignant lymphoma].

Twenty-seven patients with malignant lymphoma (14 Hodgkin's disease, 9 histiocytosarcoma, 2 plasmacytoma, 2 lympholeucosarcoma) were treated by Ailin-injection plus Chinese herbal medicine. The latter's composition and dose varied depending on the clinical manifestations. All the patients had stage III and IV lesions. The total remission rate was 70.37% (complete remission 13 patients, partial remission 6 patients, no remission 8 patients). In addition, we also studied the suppressive effect of Ailin on transplanted tumor in vivo (S-180). The suppression rates were 36.09%, 48.80%, 32.67% by three repetitions with an average of 39.18% (P less than 0.002). They were 37.25%, 35.29% on S37 with an average of 36.27% (P less than 0.005). They were 46.53%, 44.56%, 51.35%, 45.95% on Ehrlich ascites tumor cells with an average of 47.09% (P less than 0.001). The clinical and experimental studies suggest that Ailin-1 has no serious side effects and is well tolerated by patients with malignant lymphoma at moderate or advanced stages. No toxic reactions were observed at the clinical dose. In the above combination therapy, the Chinese herbal medicine has obvious supplementary effect in the treatment of the patients' cachexia and immuno-suppression.

Adolescent↗