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Biomedical subjects

Y Xi

Publications and source records attributed to Y Xi.

28 records · Page 2Linked to original sources
PubMed1996

[Inhibitory effects of antisense oligonucleotides delivered locally via hydrogel catheter on myointimal hyperplasia of rat carotid artery after nitrogen drying].

OBJECTIVE: To determine if antisense c-myb delivered locally via the hydrogel catheter inhibits the development of myointimal hyperplasia in rat carotid artery after nitrogen desiccation of the endothelium. METHODS: Forty rats were randomized into four groups (ten in each). After endothelial injury, different oligonucleotides were administered locally through the hydrogel catheter. Animals were killed at 14 days following gas drying. The lumen areas, ratios of intimal to medial areas and intimal to medial thickness were measured with the aid of computer. The q test was used for statistical analysis. RESULTS: The lumen area of antisense c-myb group (0.29 +/- 0.01 mm2) was larger than that of sense and mismatch groups (0.17 +/- 0.05 mm2, q = 4.1729; 0.18 +/- 0.05 mm2, q = 3.7489, P < 0.05), and less than that of control group (0.40 +/- 0.14, q = 3.7782, P < 0.05). The ratios of intimal to medial areas and intimal to medial thickness for antisense c-myb group (0.45 +/- 0.24, 0.57 +/- 0.24) were significantly decreased compared with sense and mismatch groups (1.26 +/- 0.25, q = 9.8913; 1.16 +/- 0.38, q = 8.4252; 2.15 +/- 0.85, q = 8.6850; 1.85 +/- 0.79, q = 6.8389, P < 0.01). CONCLUSIONS: Myointimal hyperplasia of rat carotid artery after nitrogen drying can be markedly suppressed by intravascular local delivery of synthetic antisense c-myb via hydrogel catheter. The technique is a promising to prevent artery from obstructive stenosis.

Animals↗
PubMed1996

[Effect of (+/-)12-chloroscoulerine on brain dopamine receptors].

AIM: To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors. METHODS: The receptor binding assay with calf striatum to D1 and D2 receptors, and the animal behavior tests were used. RESULTS: (+/-) 12-Chloroscoulerine (CSL) was the most potent one among the THPB and HBTI. The affinities of CSL to D1 and D2 receptors were 13 and 51 nmol.L-1, respectively. In rats, CSL showed an antagonistic effect on the stereotypy and induced catalepsy. In the 6-OHDA lesioned rats, however, CSL exerted the agonistic effect to DA receptors. CONCLUSION: CSL had dual actions to DA receptors and its effects were similar to that of (-)stepholidine.

Animals↗
PubMed1994

Comparative observation on effect of electric acupuncture of neiguan (P 6) at chen time versus xu time on left ventricular function in patients with coronary heart disease.

Paired experimental design was adopted in this experiment for comparative observation on effect of electric acupuncture (EA) of Neiguan (P 6) at Chen Time (7 a.m. to 9 a.m.) versus Xu Time (7 p.m. to 9 p.m.) on left ventricular function in patients with coronary heart disease (CHD). The results show that EA performed at Chen Time could improve the left ventricular function of CHD patients as indicated by shortening of PEPI and decrease of PEPI/LVETI ratio; on the contrary, EA performed at Xu Time prolonged PEPI and raised PEPI/LVETI ratio in CHD patients, suggesting impairment of left ventricular function.

Acupuncture Points↗
PubMed1993

A noninvasive transcutaneous alternative to rectal thermometry for continuous measurement of core temperature in the piglet.

Deep body temperature is an important and accepted index of health status in newborn infants. There are no easily used accurate methods for continuous deep body temperature measurements. Oral and tympanic membrane temperatures correlate well with rectal temperature but are not easily adapted to continuous measurement. We devised a noninvasive transcutaneous temperature sensor for continuous deep body temperature measurement that relies on the principle that, under steady state conditions, the temperature at the thermally insulated surface of a warm body, i.e. a zero heat loss surface, will be in equilibrium with the warmest part of the body. We used a standard clinical temperature probe placed between the skin and the mattress and attached to the skin with a foam adhesive disk. We used standard skin temperature probe attachment disks, which are also designed to provide thermal insulation to the skin temperature probe. We tested the hypothesis that this transcutaneous temperature would track body temperature as indicated by rectal temperature. In six anesthetized (pentobarbital) newborn piglets (1600 +/- 200 g) placed on their abdomen in a convectively warmed infant incubator, we measured continuously the following temperatures for 5 h: transcutaneous over lower and upper abdomen, brown fat, rectal, and descending aorta. To examine the influence of environment, we varied the incubator air temperature between 32 degrees and 36 degrees C. Both transcutaneous temperatures tracked the rectal temperature, within 0.2 degree C for transcutaneous over lower abdomen and within 0.3 degree C for transcutaneous over upper abdomen.(ABSTRACT TRUNCATED AT 250 WORDS)

Abdomen↗
PubMed1989

Sinus node electrogram recording in complete atrioventricular block.

Surface electrocardiogram (ECG), sinus node electrogram (SNE), His bundle electrogram (HBE), and intracardiac electrogram of high right atrium (HRA) were recorded synchronously in 11 of the 14 consecutive cases with complete atrioventricular block (CAVB). SNE showed the presence of a pre-P wave that preceded in all the P wave on the ECG and had no relationship to QRS complex or TU repolarization. This confirmed that the pre-P wave arose from the sinus node. Direct sinoatrial conduction time (SACTd) in nine cases was within the normal range (less than 120 msec). SACTd in another two cases was prolonged to 185 msec and 210 msec, respectively, suggesting their abnormal sinus node conduction.

Adult↗