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Y X Wu

Publications and source records attributed to Y X Wu.

29 records · Page 2Linked to original sources
PubMed1987

Restricted heterogeneity of polyclonal rheumatoid factors.

The electrophoretic pattern of rheumatoid factor (RF) was investigated in 40 polyclonal sera, by using radiolabeled IgG. Thirty sera specifically bound IgG aggregates, correlating with their RF titer. The binding pattern was monoclonal or oligoclonal. The molecules responsible were classic RF antibodies, as shown by using purified IgM, inhibition experiments, and by the optimal size of aggregates (2,000-4,000 kd). These data show that RF heterogeneity is restricted in polyclonal sera, and this can have a bearing on several mechanisms.

Antibodies↗
PubMedDate not supplied

Modulation of lipopolysaccharide-induced cytotoxic factor and interferon production by moxibustion in mice.

Pretreatment of mice with moxibustion (Mox) modulated lipopolysaccharide (LPS)-induced endogenous cytotoxic factor (CF) and interferon (IFN) production in serum. CF was measured by the L929 cytotoxicity test and IFN by the cytopathic effect microassay on L929 cells with vesicular stomatitis virus. Significant inhibition of CF activity was observed when Mox and LPS were applied simultaneously. Its potentiation was maximal, about 9 times the control level, when treatment intervals between Mox and LPS were 24-72 hours, and declined thereafter. Mox treatment modified LPS-induced IFN production with a similar biphasic pattern but the onset of modification was delayed. This is the first report of modulation of cytokine production by Mox treatment.

Animals↗