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Biomedical subjects

Y Weinstein

Publications and source records attributed to Y Weinstein.

99 records · Page 6Linked to original sources
PubMed1972

Regulation of antibody response by cells expressing histamine receptors.

Spleen cells from immunized and unimmunized mice were either passed over histamine-rabbit serum albumin-Sepharose columns or rabbit serum albumin-Sepharose control columns. The immune response potential of 5 x 10(6) cells excluded from the two columns were compared with each other, and with an equal number of unfiltered cells by injection of the cell suspensions mixed with sheep erythrocytes into irradiated, syngeneic recipients. The direct and indirect anti-sheep erythrocyte plaque-forming cell responses generated by the cells passed over the histamine-bead column were significantly greater than the responses resulting from the inocula of unfiltered cells or cells passed over control columns. These results indicate the existence of a cell population expressing surface receptors for histamine, which functions to regulate antibody responses.

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PubMedDate not supplied

[Interferon inhibition of lymphocyte mitogenesis].

Interferon inhibits the early phase of mitogenic action of concanavalin A on lymphocytes. There was no evidence for a role of cyclic AMP in the process of inhibition. Dialysis of interferon against high salt and urea did not separate cell inhibitory activity from antiviral activity.

Animals↗
PubMedDate not supplied

Regulation of T cell receptor gamma gene expression by cytokines in murine hematopoietic cells.

Murine IL-3-dependent myeloid cell lines express transcripts from non-rearranged TCR gamma genes and this expression is dependent upon IL-3. To investigate this observation in general terms we examined various IL-3 dependent cell lines for TCR gamma gene expression. We also examined various cytokines to test their potential to induce TCR gamma gene expression. All IL-3 dependent cell lines expressed TCR gamma transcripts. The IL-3 induced expression was sensitive to protein synthesis inhibitors. This demonstrated that the TCR gamma genes belong to the early growth factor response class. IL-3, IL-4, GM-CSF and Erytropoietin (EPO), but not G-CSF, induced TCR gene expression. 32D cells transfected with the IL-2 beta chain receptor became responsive to IL-2 as a growth factor and induced TCR gamma gene expression. The induction of TCR gamma gene expression by the cytokines was not correlated to their growth promoting activity. This indicated different signaling pathways.

Animals↗