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Biomedical subjects

Y Wakatsuki

Publications and source records attributed to Y Wakatsuki.

46 records · Page 3Linked to original sources
PubMed1989

[Non-granulomatous anterior uveitis and HLA-B27 antigen].

In Caucasians, there is close correlation between acute anterior uveitis and histocompatibility antigen HLA-B27. But in Japanese, this is not clear. Therefore, we examined 58 patients with non-granulomatous anterior uveitis (NGAU) about HLA typing in our uveitis clinic at Tokyo Women's Medical College Hospital. HLA-B27 was identified in 20 out of 58 patients (34.5%) with NGAU and it was statistically significant. We also studied the clinical features of patients with HLA-B27 positive NGAU. We found that in HLA-B27-positive NGAU, the visual acuity was more strongly affected during the attack and the duration of inflammation was longer than HLA-B27 negative NGAU patients. The duration of the first attack was longer than re-attack, and the duration of the first attack was longer than HLA-B27 negative NGAU patients. It was less commonly associated with systemic disorders in Japanese HLA-B27 positive anterior uveitis than in Caucasian. However, in Japanese NGAU patients without systemic disorders, there was the same tendency concerning the HLA-B27 positive rate as in Caucasians.

Asian People↗
PubMed1988

Distribution of vitamin B12 R-binder in carcinomas of the digestive tract.

To evaluate whether the increase in serum transcobalamin I, seen in patients with carcinoma, is caused by synthesis of R-binder to tumour cells, the distribution of vitamin B12 R-binder in 125 malignant growths of the digestive tract was studied. Positive staining for R-binder with immunoperoxidase was observed in 85 (70%) carcinomas. Positive staining for R-binder was observed in all four cholangiocarcinomas studied, but was absent in nine hepatocellular carcinomas. These findings suggest that determination of R-binder in liver tumours may be of some value in differentiating hepatocellular carcinomas and cholangiocarcinoma, and that synthesis of R-binder by tumour cells causes an increase in serum transcobalamin I.

Adenocarcinoma↗
PubMed1987

Immunohistochemical localisation of vitamin B12 R-binder in the human digestive tract.

The distribution of vitamin B12 R-binder in the human digestive tract was studied using an indirect immunoperoxidase technique. Positive staining for R-binder was found in the mucous cells and ductal epithelial cells of the salivary glands and the oesophageal glands. In normal gastric mucosa, no positive staining for R-binder was found, but in the area with intestinal metaplasia, the columnar epithelial cells and goblet cells showed positive staining. Epithelial cells of the gallbladder, intrahepatic bile ducts and pancreatic ducts were also positive for R-binder. In the small intestine and colon, R-binder was found in the columnar epithelial cells and goblet cells. The measurement of unsaturated vitamin B12 binding capacity and cobalamin content in the extracts from intestinal mucosa also indicated the presence of R-binder in the intestinal mucosa.

Adult↗
PubMed1987

Distribution of vitamin B12 R binder in normal human tissues: an immunohistochemical study.

We studied the distribution of vitamin B12 R binder in various normal human tissues by use of an immunoperoxidase technique. Positive staining for R binder was observed in almost all glandular epithelia of digestive system, bronchial glands, renal proximal tubules, prostate, uterus, Fallopian tube, mammary gland, and sweat glands. The distribution of R binder was similar to that of lactoferrin and secretory component. These findings support the hypothesis that R binder plays a role in the local defense mechanism.

Digestive System↗
PubMed1987

Fluorescein iris angiography and anterior segment fluorophotometry in patients with Behçet's disease.

Fluorescein iris angiography and anterior segment fluorophotometry were performed in 63 eyes of 34 patients with Behçet's disease during its remission stage. Thirty normal eyes were studied as the control. A variety of leakage patterns comprising posterior chamber leakage and paravascular leakage were detected in 32 eyes with Behçet's disease by means of fluorescein iris angiography, while no leakage was detected in the control eyes. These leakage patterns were frequently seen in the posterior type uveitis group of Behçet's patients, but were scarce in the anterior type uveitis group. By anterior segment fluorophotometry, the levels of fluorescein concentration in the anterior chamber were significantly higher in the posterior type uveitis eyes of Behçet's patients than those in either the anterior type uveitis eyes or the controls (P less than 0.05-P less than 0.01). The results indicated that the damage to the vascular system still existed in the remission stage of the disease, and that this abnormality occurred more markedly in the posterior type group than in the anterior type group of Behçet's disease eyes.

Adolescent↗
PubMed1987

Cobalamin-binding protein in gastric juice as a new tumor marker in gastric cancer.

Cobalamin-binding protein (binder) in gastric juice was studied as a biochemical marker of gastric cancer. Fasting gastric juice of cancer patients and controls with benign disease was used for separation of cobalamin binders by gel filtration and DEAE-cellulose column chromatography. Physicochemical properties of the binder in gastric cancer patients were shown to have a larger molecular size and more acidic isoelectric point than the control binder. The binder was found in the gastric juice of all patients with early gastric cancer. Detection of the binder may be clinically valuable as a possible marker in the diagnosis of gastric cancer.

Chromatography, DEAE-Cellulose↗