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Biomedical subjects

Y Wada

Publications and source records attributed to Y Wada.

At least 595 records · Page 33Linked to original sources
PubMed1995

Retinal detachment in patients with atopic dermatitis. 5-year retrospective survey.

We surveyed data collected in our department over the past 5 years on all patients under the age of 30 years who had presented for repair of retinal detachment. Of 52 such patients, 10 (19.2%) had a documented history of atopic dermatitis. Three (27.3%) of the 11 eyes (10 patients) with atopic dermatitis exhibited a break in the ciliary epithelium in the pars plicata and pars plana, the most characteristic finding in this group. Surgical reattachment of the retina was accomplished in all 11 eyes. To repair a tear in the ciliary epithelium in atopic cases, we prefer using an encircling procedure to reconstruct an artificial ora serrata.

Adult↗
PubMed1995

Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM.

The ligand for CD40 (CD40L) is a membrane protein on activated T cells that induces B cell proliferation and differentiation. Several mutations of the CD40L gene were reported responsible for defective class switching of B cells in an X-linked immunodeficiency with hyper IgM (X-HIM). We studied four affected males from three families and found three independent mutations including new mutations of CD40L gene. In every X-HIM patient tested, however, anti-CD40 plus IL-10 did not induce class switching from IgM to IgG or IgA, even in the presence of Staphylococcus aureus Cowan I strain (SAC). CD4+ T cell clones, expressing CD40L on their surface, also did not rescue IgG or IgA induction by X-HIM peripheral blood B cells in vitro. But signaling through CD40 induced both B cell proliferation and IgE secretion when IL-4 was added to the culture. Taken together, these results show that in vitro signaling through CD40 rescues IgE but not IgG or IgA secretion by peripheral blood X-HIM B cells and suggest that in vivo CD40 and CD40L interaction might be necessary for IgG and IgA differentiation in X-HIM.

Amino Acid Sequence↗
PubMed1995

Wilson's disease-like lesion in a calf.

Wilson's disease-like lesion was seen in a 2-month-old calf. Fibrosis was apparent in the liver, but there was no cholestasis or icterus. Marked spongy degeneration was seen in the central nervous system. Hepatic and brain copper values were significantly higher than normal: 1970 and 113 ppm dry matter, respectively. Serum ceruloplasmin was lower than normal: 17.5 U/liter. Etiology of this disease was unknown, but there is no evidence that the calf ingested a large quantity of copper.

Animals↗
PubMed1995

Inhibitory effects of interleukin-1 on growth hormone secretion in conscious male rats.

Although various pathophysiological effects of interleukin (IL) on the CRF-ACTH-adrenal axis and gonadotropin secretion have been studied extensively, the effects of IL on GH secretion still remain to be elucidated. We investigated the possible effects of IL on GH secretion in six groups of conscious rats. In four groups, IL was administered by continuous iv infusion and in the other two, by intracerebroventricular injection. Saline-treated rats served as controls for these groups. Sequential blood sampling was performed every 20 min in all groups, and the plasma GH concentration was determined by RIA. The expression of hypothalamic c-fos protein in a separate group was examined by immunohistochemistry. Continuous infusion of both IL-1 alpha and IL-1 beta (10 ng/min) significantly inhibited GH surges. The plasma IL-1 level was elevated to 2-3 ng/ml. Continuous iv infusion of IL-2 and IL-6 had no effect on GH secretion. The intracerebroventricular injection of both IL-1 alpha and IL-1 beta significantly inhibited GH surges, and the inhibitory effect was much greater for IL-1 beta than for IL-1 alpha. Continuous iv infusion of IL-1 beta markedly stimulated c-fos expression in specific hypothalamic nuclei, particularly in the paraventricular nucleus. These findings suggest that, in the rat, IL-1 inhibits GH secretion through its peripheral and central actions.

Animals↗
PubMed1995

Effect of long-term fluvoxamine treatment on endogenous serotonin uptake inhibitor-like substance in monkey cerebrospinal fluid.

We found that substances present in monkey cerebrospinal fluid (CSF) could inhibit [3H]-paroxetine binding in monkey brain preparations. The molecular weight of one of these inhibitory substances was approximately 2000, which is in agreement with earlier studies using human CSF. We also found that the inhibitory effect of the substances present in monkey CSF on [3H]-paroxetine binding decreased after 8 weeks of chronic fluvoxamine (5 mg/kg day, p.o.) treatment. These results suggest that the ability of a drug to decrease the activity of endogenous 5-HT uptake modulators may related to its antidepressive effects.

Animals↗
PubMed1995

Natural infection with attaching and effacing Escherichia coli and adenovirus in the intestine of a pigeon with diarrhea.

Attaching and effacing Escherichia coli (AEEC) and adenovirus infections in a 6-month old pigeon were found by retrospective histologic examinations. Histologically, numerous gram-negative bacilli covered the surface of the enterocytes of the ileum. Brush borders were not sharply defined on the apical enterocytes at the sites of bacterial attachment. Scanning electron microscope showed that much of the mucosal surface was heavily colonized by bacilli and that the microvilli were lost. Many intranuclear inclusions were seen in enterocytes from the duodenum to the cecum. On transmission electron microscopy, adenovirus-like particles were observed in the nuclei of enterocytes.

Adenoviridae↗
PubMed1995

[Chronic cytomegalovirus infection that present specific clinical course--a case of a boy with common variable immunodeficiency].

We describe an 8-year-old boy with CVID and chronic CMV infection. Although at onset he was diagnosed as IgA deficiency, 4 years after his clinical manifestations because compatible to CVID. During his clinical course he had suffered from various disorders as follows; AIHA, interstitial pneumonia, hemophagocytic syndrome, chronic gastroenterocolitis and so forth. At the age of 8 the PCR of CMV-DNA of biopsy specimen from colon, lung and bone marrow were confirmed to be positive. Hematological examinations revealed abnormal cellular immunity such as decreased CD 4/8 ratio with increased HLA- DR+ CD 8+ T cell, decrease of absolute blood lymphocytes count and reduced response of lymphocytes to blastogenetic agents. These findings brought us to diagnose him as having CVID complicated with chronic CMV infection. This case gives us some impact to speculate what role CMV infection plays in CVID, Whose etiology is unknown.

Anemia, Hemolytic, Autoimmune↗
PubMed1995

CT evaluation of hepatic tumors: comparison of CT with arterial portography, CT with infusion hepatic arteriography, and simultaneous use of both techniques.

OBJECTIVE: We hypothesized that CT with arterial portography (CTAP) might depict tumors undetected by CT with infusion hepatic arteriography (CTIHA), and the converse. Accordingly, we compared the detection rate of malignant tumors using CTAP, CTIHA, and simultaneous use of both techniques to determine whether CTIHA can be used to distinguish malignant from benign hepatic nodules. SUBJECTS AND METHODS: Fifty-four candidates for partial liver resection who underwent combined CTAP and CTIHA were studied. Histopathologic study confirmed 77 malignant and 15 benign nodules in these patients. CTAP, CTIHA, and combined CTAP and CTIHA were used by three observers before surgery, and the sensitivities of the three methods in detecting malignant tumors were compared. Contrast-enhancement patterns of the nodules on CTIHA scans were determined. RESULTS: Sixty-eight malignant nodules (88%) were detected with CTAP, 64 (83%) with CTIHA, and 69 (90%) with simultaneous interpretation of both scans. These differences were not significant. CTIHA showed 16 malignant and 12 benign small nodules. Of these, 13 malignant and two benign nodules had rim enhancement. Use of rim enhancement as the criterion for malignancy of these small nodules gave an accuracy rate of 82%. CONCLUSION: CTAP, CTIHA, and simultaneous use of both techniques are similar in their ability to detect malignant hepatic tumors. CTAP alone is recommended for the detection of malignant hepatic tumors. CTIHA is of value in differentiating malignant from benign small nodules.

Adult↗
PubMed1995

A mouse model of a sudden death induced by noise exposure is useful to investigate human responses to physical stress.

Stress has become an increasingly important occupational health matter in Japan. We found that noise exposure, 6 kHz wave and its higher harmonics at the sound pressure level of 112 dB, induced typical audiogenic seizures in the MRL/l mouse strain. The seizures are often fatal. Wild running preludes to seizures. Inhibition of wild running by restricting animal's activities successfully prevented the seizures, suggesting that an excessive physical load is a necessary step. The present finding indicates that MRL/l mice may be a useful model for human sudden deaths after excessive work loads.

Acoustic Stimulation↗
PubMed1995

Adult idiopathic chondrolysis of the hip--report of two cases.

Idiopathic chondrolysis of the hip is characterized by pain, limping and a progressive restriction in the range of motion of the hip. The paper describes the case of two female patients, age 28 and 37, who were referred to our hospital in October 1985 and May 1991 for pain and limitation of movement in the right hip. Neither patient had a previous history of systemic illness or trauma or medication such as steroids. On admission they underwent clinical and X-ray examinations. Both required an open biopsy to confirm the diagnosis. They have been followed for 4 years and 8 years, respectively.

Adult↗
PubMed1995

Imaginary gaze effects on eye movements induced by linear acceleration: involvement of vestibular induced smooth pursuit eye movement.

We investigated smooth eye movements elicited i) by linear acceleration in a space-fixed imaginary gaze condition (smooth component of eye movement induced by linear motion: LSEM) and ii) during acoustic pursuit of a moving sound source (smooth component of eye movement induced by acoustic pursuit of a sound source: SSPEM). The two conditions were examined using the same test subjects. LSEM and SSPEM performance was found to be positively correlated across the subject population. From the comparison of LSEM and SSPEM we propose the following hypothesis: LSEM consists not only of a pure translational vestibular-ocular reflex (tVOR) component but also of a component based on the perception of otolithic information. Accordingly, this second component is instrumental in the pursuit of an imaginary visual target during linear self-motion.

Acceleration↗
PubMed1995

Mark-release-recapture experiments to estimate the efficiency of the light trap in collecting Japanese encephalitis vector mosquitoes.

Efficiency of the light trap in collecting females of Culex tritaeniorhynchus, the principal vector mosquito of Japanese encephalitis, was evaluated by mark-release-recapture experiments. Females collected with dry ice in the field were marked and released in a pigsty. The recapture rate of marked females by the light trap was so low as around 1% or lower. Owing to this low efficiency, it is not likely that the light trap can be a useful tool in the control of Japanese encephalitis.

Animals↗
PubMed1995

[Surgical treatment of incomplete endocardial cushion defect in adult patients].

Seven adult patients (> or = 40 years old) and six pediatric patients with incomplete endocardial cushion defect (ECD) underwent corrective surgery in our institution. Preoperative catheterization study showed that the left-to-right shunting rate and the pulmonary-to-systemic flow ratio were greater in adult patients than those in pediatric patients, but systolic pulmonary arterial pressure was not high and similar in the two groups. The degree of mitral regurgitation by left ventriculography was mild or moderate in both groups. However, in adult patients, a variety of arrhythmias were observed. Postoperatively, NYHA grades and arrhythmia improved markedly in the adult patients. Surgical correction for ECD is recommended even in adult patients before aggravation of cardiac failure and arrhythmia.

Adult↗
PubMed1995

[The effect of corneal epithelial cells on the collagen gel contraction by keratocytes].

To understand the mechanism of corneal stromal wound contraction, we investigated the effect of corneal epithelial cells on the collagen gel contraction by keratocytes. Subcultured rabbit keratocytes embedded in type I collagen gel were cultured. Rabbit corneal epithelial cells were also cultured and the cultured medium was collected and used as an epithelial cell conditioned medium (ECCM). The collagen gel contraction by keratocytes was estimated by measuring the diameter of the collagen disc once a day for 5 days. The diameter of the collagen gel decreased in proportion to the number of keratocytes in the presence of fetal calf serum (FCS), but it decreased in inverse proportion to the concentration of collagen. The collagen gel contraction by keratocytes was enhanced by the addition of ECCM in a dose dependent manner. This stimulatory activity was found in ECCM obtained from 3 to 7 day cultivation of corneal epithelial cells. These findings demonstrated that keratocytes contracted collagen gel in the presence of FCS. It also appeared that corneal epithelial cells secrete a factor or factors that stimulate the collagen gel contraction by keratocytes.

Animals↗
PubMed1995

[Comparison between anomia with word comprehension difficulty and Gogi aphasia due to lobar atrophy].

We used naming and pointing tests and a proverb completion task to compare two cases of aphasia that exhibited a selective disturbance of word processing. One patient had anomia with word comprehension difficulty due to partial ablation of the left temporal lobe and the other patient had Gogi aphasia due to lobar atrophy with left temporal predominance. We presented 90 pictures of common objects divided into 9 categories in the naming and pointing tests, and used 10 well-known Japanese proverbs as stimuli in the proverb completion task. Performance of the naming and pointing tests was severely impaired in both patients. In the patient with anomia, words the patient could not name or point to varied from session to session and phonemic cue effects were frequently observed. The proverb completion phenomenon was positive. These findings indicate that the patient had an obstruction of the access route to the intact word store or a partial rarefaction of the word store itself. In the patient with Gogi aphasia, the words the patient could not name or point to were consistent from one occasion to another, and no phonemic cue effects or signs of familiarity were observed at all. The proverb completion phenomenon was totally negative. These findings indicate that the patient has lost the word store itself. MR images in the case of anomia revealed a lesion extending from the anterior to the central portion of the inferior part of the left temporal lobe. In the case of Gogi aphasia, the MR images displayed knife-edged focal atrophy in the anterior aspect of both temporal lobes, more prominently on the left.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1995

[Generalized angitis and recurrent infection associated hemophagocytic syndrome in a girl with XXX syndrome].

We have encountered a case of a girl with XXX syndrome who had infection associated hemophagocytic syndrome (HPS) recurrently. The patient presented hyper-gammaglobulinemia during the clinical course and developed IAHS probably because of infection with Rubella virus and EB virus each as a trigger. Diseases that cause abnormality in X chromosome are said to present immune abnormality such as SLE in many cases. It is possible that the excessive X chromosome in this cases partially concerned with such as an immune abnormality as to cause recurrent IAHS.

Adolescent↗
PubMed1995

[A successful usage of latissimus dorsi muscle flap in the surgery of synchronous gastric and pulmonary double cancer in an elderly patient--a case report].

A 77-year-old man, with both an advanced gastric cancer Borrman IV type (CME) S2N1P0 M0 stage II and lung cancer of left upper lobe pT3N1M0 stage IIIA, simultaneously received total gastrectomy with R2 lymph node dissection, and Roux-Y reconstruction, and left upper lobectomy with R2 lymph node dissection combined with partial pericardiectomy. A latissimus dorsi muscle flap with thoracodorsal artery and vein was used for covering the intrathoracic esophagojejunostomy, repairing of the pericardial defect and separating the thoracic cavity from the abdominal cavity. Postoperative esophagograms showed a leakage, which was localized by the muscle flap coverage without extensive spread. The leakage healed spontaneously after a left sub-diaphragmatic drainage. Our experience described here indicates that a latissimus dorsi muscle flap coverage is a useful operative method for double cancers of the lung and stomach requiring intrathoracic procedures.

Aged↗