[Protective effect of a thromboxane synthetase inhibitor, OKY-046, in patients with acute respiratory failure].
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Biomedical subjects
Publications and source records attributed to Y Usui.
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Isolated aneurysm of the iliac artery is considered to be a rare disorder, although iliac aneurysm associated with abdominal aortic aneurysm is more common. Its clinical diagnosis is difficult, because symptoms are absent if an aneurysm is small, and because symptoms often mimic urogenital, neurological or gastrointestinal diseases if an aneurysm grows large without rupture. We reported a 40-year-old woman with isolated aneurysm of the left external iliac artery caused by giant cell arteritis, and surgically treated with success.
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Resected or polypectomized materials of colo-rectal cancer are morphologically analyzed in order to estimate their developing pattern. A retrospective review of previous radiological or endoscopic findings is also made in the patients who had either or both of examinations in the past. Morphologically, a distribution chart of colo-rectal cancers by their size and height is made, and a zone of colo-rectal cancers with the same morphological features is drawn. Retrospectively, type 1 advanced cancer appears to develop from Is type early cancer, and morphologically, a zone of Is type early cancers and that of type 1 advanced cancers partly overlap each other. The retrospective review also suggests that type 2 advanced cancer seems to develop from type Is, IIa or IIa + IIc early cancer. On the distribution chart, a zone of type 2 advanced cancer is partly superimposed over or bordered by that of early cancers type Is, IIa or IIa + IIc. Thus, it may fairly be said that advanced cancer develops from early cancer with its zone on the distribution chart partly superimposed over or bordered by that of the advanced cancer. Among early cancers, sessile type, superficial elevated type or elevated type with central depression may develop to advanced cancer. Both morphological analysis and retrospective radiological or endoscopic review of colo-rectal cancers would suggest the developing pattern of pedunculated or flat type early cancer.
An alkali-stable polysaccharide (called compact-colony forming active substance; substance 1) obtained from the cell surface of a strain of Staphylococcus epidermidis caused gel formation of human fibrinogen, with no release of fibrinopeptides. Substance 1 possessed neither esterase nor caseinolytic activities; no inhibition of gel formation was shown by dinitrofluorophosphate. Heparin and galactose prevented gel formation of fibrinogen with substance 1. With the addition of early- and late-fibrinogen or fibrin degradation products into the fibrinogen sample, no prolongation of the gel formation time was observed. This substance is, therefore, assumed to nonenzymatically induce gel formation with fibrinogen, a process resembling paracoagulation.
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Using a strain of group B Streptococci, characteristics of the streptococcal clumping factor was investigated. In contrast to that of Staphylococcus, the streptococcal clumping factor reacted with plasmas from guinea-pig and sheep although staphylococcal clumping factor did not react with them. In addition, streptococcal clumping factor was resistant to heat, sonication, and chemical reagents; it was also degradable by proteolytic enzyme and galactose oxidase. Hydrochloric acid extract of the whole cell was subjected to Sephadex column chromatography and fraction containing streptococcal clumping factor was obtained. This fraction reacted selectively with fibrinogen in human plasma, caused paracoagulation, and the factor was presumed to be an acidic proteinaceous substance.
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A protein fraction containing a high amount of hydroxyproline was found in the capsule of the Smith diffuse strain (encapsulated) when compared with that of dialysate medium. This content varied depending upon temperature, oxygen supply, sodium chloride, and carbohydrates. The hydroxyproline content of the single proteinaceous fraction, obtained by Sephadex G-200 column chromatography, was one fourth of the total amino acid composition.
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Serum albumin was identified as an auxiliary factor enhancing the substance active in compact-colony formation by strains of S. aureus when cultivated in serum-soft agar.